The oldest medical report of a near-death experience dates to around 1740

Near-death experiences have been reported across cultures across for millennia

This collection of ten of the earliest recorded NDEs gives an idea of how pervasive the phenomenon really is. Stories range from ancient Greek philosopher Plato telling the story of a soldier named Er to a first-century Japanese monk who claimed to have visited both heaven and hell.

Psychiatrist Bruce Greyson created a scale to identify and rate NDEs

Researcher Bruce Greyson is one of the world’s leading experts on near-death experiences. This article explores what the field of NDE research has learned over the last five decades, discusses the difficulties of studying such a controversial topic, and outlines what we’ve ruled out as the cause of these events.

Around 5% of people report memories of a near-death experience

Near-death experiences are moments reported by people who’ve come close to death, often associated with bright lights, out-of-body sensations, or encounters with otherworldly beings. While scientific research offers theories ranging from brain chemistry to psychological coping mechanisms, no single explanation fully captures the mystery of these experiences.

The body's response to cardiac arrest has been linked to near-death experiences

Most people who report near‑death experiences experience events like out‑of‑body sensations, altered cognition, emotional and spiritual shifts, or even supernatural phenomena, particularly during cardiac arrest. Research suggests many such experiences may be linked to brain-generated sensory distortions that can be experimentally replicated, suggesting a physiological rather than mystical cause.

An avowed rationalist discusses his near-death experience

Documentarian Sebastian Junger, a veteran reporter and skeptic discusses his experiences—in particular, a frightening vision—after an aneurysm and internal hemorrhaging left him nearly dead. Junger talks about his NDE, the possible scientific explanations, and how that day changed his fundamental worldview.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Play 17th-century death roulette

Before modern science and medicine, death was much harder to escape. Using real mortality records from London's Dreadful Visitation–a collection of all the Bills of Mortality from 1665–this interactive game gives you an idea of what may have possibly killed you during the Great Plague. Grow your appreciation for life today as you stumble upon causes of death like “livergrown” and “drowned at St. Katharine’s by the Tower”.

Read the original 1907 paper on the first known Alzheimer's patient

Alzheimer's disease was first identified by Dr. Alois Alzheimer in 1901, following a postmortem brain examination of a patient experiencing memory loss and other symptoms. Alzheimer's original paper was largely lost until 1995, when an English translation was published in a medical journal.

Scientists are reconstructing ancient smells—including a 3,500-year-old ancient Egyptian mummy

Researchers explain how they have recreated the scent of ancient Egyptian mummies and enabled museum-goers to experience that scent on specialized cards. The exhibit will be at the Royal BC Museum in Canada in June 2026.

Synesthesia: when sensation in one sense triggers an unrelated sense in the brain

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

1 in 15 adults over age 40 experience phantom odors

This phenomenon was measured in a 2018 study that examined the prevalence and risk factors for phantom odor perception. Older adults were less likely to experience these phantom odors as they age, just as their overall sense of smell declines. Women are more likely than men to perceive phantom odors.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

How the placebo effect became mainstream

Contemporary patients and medical students take the placebo effect for granted, as its a standard element in most drug trials. But the concept was only first debated and standardized in the 1950s after a ground-breaking 1955 paper by medical...

Food allergies were first documented more than 4,000 years ago

Although food allergies are on the rise in modern times, they have been documented in written records for thousands of years. More than 3,000 years ago, Chinese emperors advised patients to avoid certain foods, and Hippocrates noted in his work that food could cause serious harm to certain individuals, and even lead to death.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

19th-century Americans used technology to try to prove the existence of ghosts

In the 19th century, following technological advancements like the telegraph, phonograph, and others, efforts were made to capture proof of ghosts. These technologies seemed supernatural in their own right and emerged at the same time Spiritualism took off in the US, resulting in new approaches to connecting with the dead.

A pediatric journal ran 138 fictional case studies, and 61 were cited as real stories

The Canadian journal Paediatrics & Child Health issued corrections to 138 case studies published since 2000, acknowledging the cases were entirely fictional—a practice intended to protect patient privacy that was never disclosed to readers. At least 61 of the fabricated reports were cited as fact in other peer-reviewed journals a combined 218 times, including a 2006 Lancet article alleging an infant died from opioid-laced breast milk.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

In the 1960s, Virginia became home to the first emergency department in the US

It was a 450-square-foot basement room with four stretchers staffed by four doctors inside Alexandria Hospital, in Alexandria, Virginia. Patients there were charged $5 per visit. The first emergency medicine residency followed in 1970, in Cincinnati.

A mescaline-induced hallucination stayed with Jean-Paul Sartre throughout his life

In 1935, Sartre was injected with mescaline, a psychedelic drug that was then used to treat alcoholism and depression, by his friend at the Hôpital Sainte-Anne in Paris. It was not a good trip: Sartre saw nightmarish crabs for days and suffered a mental breakdown. For the rest of his life, crustaceans like the ones he saw during the hallucination appeared in his works.

The peer support movement may date back to 18th century France

At the Bicêtre Hospital, an asylum near Paris, Jean-Baptiste Pussin (who had previously been a patient but later led the hospital administration) tried to hire as many staff as possible from among recovered patients. Chief physician Philippe Pinel found these individuals to be kinder than other staff and "averse from active cruelty" which was common at the time. This approach allowed the facility to move away from shackling patients and other violent methods.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

The 16th-century astrologer Nostradamus' predictions for 2024

Nostradamus has been credited with predicting several major historical events over the years, but what does he think is in store for 2024? Read up on what his mysterious 1555 book, The Propheties, hints at for the upcoming year.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

Read Charles Darwin's description of his tinnitus suffering

When he was 57 years old, Darwin wrote to a new doctor about his suffering from a variety of maladies, including "singing of ears", vomiting, recurring flatulence, vomiting, and more. He noted how he believed his stress contributed to these symptoms.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.