When was the first blood transfusion?

Cross-species transplantation has been attempted in medicine for more than 300 years

Early reported xenotransplantation attempts included 17th century efforts in France to transfuse blood from animals into humans. The poor results prompted France to issue a xenotransplantation ban. In the 19th century, researchers tried animal-to-human skin grafts from species including sheep, rabbits, dogs, cats, rats, chickens, and pigeons.

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

See the first dog ever treated with insulin—a peptide

Frederick Banting and his graduate student Charles Best were the first to isolate the peptide insulin from dogs. They induced diabetes in the animals and then treated them with this peptide.

Blood evolved many times over hundreds of millions of years

The earliest evidence of a blood-like substance comes from ancient arthropods, which appear to have had copper-based blood. In the 500 million years since then, some creatures have grown to rely on other variants, such as humanity's iron-based blood.

An interactive explanation of blood transfusion

The antigens and Rh factors of blood cells (which determines your blood type) must be compatible with your immune system—which is why blood transfusions between patients must have matching types. In a mismatch, the immune system will attack and destroy donor blood cells, triggering a potentially fatal reaction.

A brief history of human blood groups

The blood group that determines whether you have type A, B, AB, or O blood was discovered near the turn of the 20th century. This short academic article dives into three main theories about the evolution and emergence of blood groups, the exact nature of which remains unclear.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

How did segregation in the US affect blood donations?

When the US established its first nationwide network of blood banks in 1941 with the hopes of restoring the dwindling reserves of military members, it was quick to emphasize blood donated by Black Americans wouldn't coat the veins of white servicemen. Historians say this policy was meant to appease white Southerners who believed Black blood was inferior to their own.This policy was leaked to the press that same year.

The word 'vampire' appeared in the English-speaking world in the 1730s

However, earlier mentions of creatures with similar characteristics existed throughout Medieval Europe. For example, people often spoke of revenants—restless dead creatures who tormented the living. Historians believe these stories grew in popularity in part because of influence from the Catholic Church, which was emphasizing the idea of purgatory. These older revenant stories eventually influenced modern vampire folklore.

Bone marrow transplants were the first successful type of stem cell therapies

Bone marrow contains two types of stem cells: Skeletal (develop into bone, cartilage, and more) and hematopoietic, which create new blood cells. The latter are critical in bone marrow transplants, and give the recipient the ability to create healthy blood cells to fight diseases like leukemia.

Englishmen in the 17th century mixed their blood into wine to show devotion

In order to demonstrate their love for a woman, some young Englishmen would stab themselves in the arm and mix the blood into their wine. They'd then toast the object of their affection and drink to their honor.

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

Cholera was called the 'Blue Death'

In the mid-1800s—when John Snow identified cholera in London—the disease was known simply as the "Blue Death." That's because blood would thicken in patients' veins when they were struggling with extreme dehydration. As a result, their skin would turn a blueish hue as their blood was starved of oxygen.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

In 1933, the influenza virus was first identified through “ferret flu” experiments

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

Look through this WWI stretcher bearer's bag

While it was indeed the first industrialized war, medical science had yet to catch up on the battlefield. This nearly eight-minute video sorts through the contents of a World War I stretcher-bearer's satchel. A modern doctor and ex-officer assesses the bag's various medical tools for performing first aid on the battlefield.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

The mosquito's role in the transmission of malaria was confirmed in 1897

The British army doctor Ronald Ross, who later won the Nobel Prize for his work, was the first to describe the transmission of malarial parasites by mosquitoes. He had lab mosquitoes suck blood from malaria-infected people and separately found the malaria parasite inside a mosquito's gut, confirming the bug's role in malaria transmission.

Hear the story of the first paramedic services, which grew out of a community training program in 1960s Pittsburgh

Before 911 existed, cities sent police cars or hearses from funeral homes to medical emergencies. In 1967, a group of young Black men in Pittsburgh changed that, developing the training protocols and lifesaving techniques that became the foundation of modern EMT response.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Rabies kills more than 50,000 worldwide each year

Rabies transmission to humans typically comes from an infected animal, and death was very common before recent protocols were developed (post-exposure prophylaxis). The virus is neurotropic, which means it has an affinity for nerve tissue, and moves quickly from broadly infecting the body to destroying the brain.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

A thousand medieval dog names

In the Middle Ages, hunting was more than a sport—it was a vocation. Hounds were a crucial element of hunting, and wealthy landowners owned hundreds of them. A scribe in the late 15th century recorded more than 1,000 authentic names given to dogs, prompting a historian to speculate this showed just how well dog-handlers knew their animals. See the names here.

Read the original 1907 paper on the first known Alzheimer's patient

Alzheimer's disease was first identified by Dr. Alois Alzheimer in 1901, following a postmortem brain examination of a patient experiencing memory loss and other symptoms. Alzheimer's original paper was largely lost until 1995, when an English translation was published in a medical journal.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

A history of treating frostbite

Amid Napoleon's invasion of bitterly cold Russia, soldiers succumbed to frostbite by the thousands. Nineteenth century doctors recommended walking and rubbing snow around the affected area. Fast forward to recent years, and the FDA has approved its first ever drug to treat frostbite. Listen to this podcast to learn the history of this wintry affliction.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.