In 1968, a Harvard Medical School committee issued the first neurological definition of death

Brain death is a medical diagnosis without any wiggle room

Seeking to resolve long-standing variations between hospitals and state procedures, in 2023 several expert groups published comprehensive step-by-step guidance for clinicians to follow when determining brain death in kids and adults. Among other guidelines, it stated that doctors don't need to get family consent to do the tests needed to make this determination.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Brain death is a uniquely modern problem stemming from modern ventilators

Patients who would have once died from devastating brain injury can now live on a ventilator for a long period of time, creating ethical, medical, and legal dilemmas.

Brain death is very rare—only 2% of hospital patients have brain death in the US

A peer-reviewed analysis examining US hospital billing code data from 2012 to 2016 concluded that the incidence of brain death is about 2% in the country. There was no available information indicating what proportion of those patients underwent organ donation.

When is someone actually dead?

Death is a process, not a sudden flip of a switch. Technology can now interrupt this process at various stages, begging the question of when exactly death happens in the dying process. This 33-minute podcast episode explores this question and the...

Observant Catholics can donate organs because the official Catholic stance is brain death is death—enabling organ donation

The Vatican states that brain death, when properly diagnosed, means that a person is dead even though machines can keep them alive. That official stance from Catholic leadership and echoed by most Catholic doctors and ethicists enables the families of observant Catholics to proceed with organ donation.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

Thanatology is the study of death and dying

Watch this video exploring the evolution in how researchers are studying and understanding death in the context of recent scientific research. CPR to restart hearts, ventilators, and other discoveries have challenged the way we think of death and scientifically upended the idea of death as a single moment.

More than 40 states have passed versions of the Uniform Declaration of Death Act

The 1981 model law, now enacted in most states, is the legal basis for death in the US. There have been many efforts to amend this law, citing the need for more transparency to improve trust between families and the medical profession, though none have moved forward. Alterations to the law could have implications for organ donations and removing life support.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

The history of brainwashing in America

"Brainwashing" refers to a coerced shift in worldview, often associated with cults or oppressive totalitarian governments. Though such processes are not well understood on a neurological level, they hold an outsized role in public imagination, particularly in science fiction and dystopias. This article reviews the history of the term, first popularized by Edward Hunter in 1950, and the subsequent use of the approach in pop psychology, the CIA, and more.

Colorado legislates neural and biological data generated by the nervous system

The law expands personal privacy protections to include data from brain activity, marking the first legal step of its kind in the US. It targets companies involved in consumer neurotechnologies, which were previously not required to restrict user data access.

The oldest medical report of a near-death experience dates to around 1740

In 2014, Dr. Philippe Charlier, a medical doctor and archeologist, found a French medical book from 1740 that described the near-death experience of a pharmacist. Using the Greyson Scale, Charlier found that the incident would have rated at least 12/32, more than high enough to scientifically classify as an NDE by today’s standards.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

For most of recorded history dreams were considered divine in origin

The first venture into modern dream interpretation may have been when ancient Greek philosopher Heracleitus proposed dreams were created within the mind. In the late 1800s, the rise of psychoanalysis theorized that dreams content revealed truths about one's psyche, while the invention of the electroencephalogram linked dreams to brain functions.

A history of "Memento Mori," from the ancients to today

The ancient Latin phrase 'memento mori' means 'remember you will die.' The counterintuitive utterance has long provided a moral and spiritual framework for individuals to evaluate their life's decisions and worldview. Though it appears morbid at first glance, the saying is meant to inspire a thirst for life. Review the various ways the idea has inspired different cultures in this article, from the Romans and Egyptians to contemporary tech leaders like Steve Jobs.

A living will is a legal document spelling out your medical wishes for emergency care

This legal document makes it explicit if you want medical interventions in the event of an emergency, including CPR, feeding tubes, ventilator assistance to push air into your lungs to help you breathe, and more. Talking with your doctor about this is covered by Medicare.

Take a quiz to discover your brain care score

Each year, nearly 800,000 Americans have a stroke. With such a high occurrence rate, you may be asking yourself what you could do now to prevent a future stroke. Researchers at Harvard collaborated to answer this question by coming up with a "Brain Care" scoring system. Take the quiz to learn the quality of your brain health today and pick up helpful insights to lower your risk of stroke and dementia well into the future.

Are the mind and brain the same? An overview of mind-body identity

A major philosophical debate asks whether the mind and the brain are two words for the same thing. Here's a quick overview of that idea.

What a railroad spike through the head taught science about the brain

In 1848, a railroad worker survived an accident that drove a 13-pound iron bar through his head. The injury changed his personality, and our understanding of the brain.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

Why the nature of consciousness is such a difficult problem

David Chalmers is one of the leading philosophers of consciousness. In this video, he outlines some of the major questions in this field, including the "hard problem of consciousness," which seeks to find neural correlate for every conscious experience.

Despite the rules, a Nobel Prize in medicine has been awarded posthumously

Ralph Steinman, whose work revealed how dendritic cells activate immune responses, passed away just days before being named a Nobel laureate. Although Nobel Prizes cannot be awarded posthumously, the committee made an exception because they believed he was alive at the time of the decision.

Menopause affects the brain in complex ways

Lisa Mosconi, a neuroscientist studying the impact of menopause on the brain, explains in this video how menopause directly impacts a woman's brain health and explores why this is an important and often overlooked area in menopause and women's aging healthcare discussions.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

11 people died from firework injuries in the US in 2024.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

Despite being favored by 87% of Americans, Congress does not have term limits.

A century of Billboard issues documenting the evolution of popular music.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.