Brain death is a uniquely modern problem stemming from modern ventilators

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Brain death is a medical diagnosis without any wiggle room

Seeking to resolve long-standing variations between hospitals and state procedures, in 2023 several expert groups published comprehensive step-by-step guidance for clinicians to follow when determining brain death in kids and adults. Among other guidelines, it stated that doctors don't need to get family consent to do the tests needed to make this determination.

A 13-year-old was declared brain-dead yet went through puberty on a ventilator

This podcast details Jahi McMath's highly controversial case. She was declared brain-dead in 2013 following surgical complications, but her family, citing religious beliefs, kept her connected to a ventilator for the five years that followed. She continued to grow and went through puberty before being issued a second death certificate in New Jersey.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

Four in 10 CPR patients report consciousness not captured by standard measures

A recent study found people revived by CPR after cardiac arrest reported they experienced some amount of consciousness during clinical death, suggesting our brains are capable of thought and memory for significantly longer after death than previously thought.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

Traumatic brain injury is a leading cause of brain death—and TBIs are trending up

Traumatic brain injury-related deaths have generally increased between 2000 and 2023, growing from roughly 49,000 to more than 68,000 in 2023. Firearm-related suicide is the most common cause of TBI-related deaths in the US, according to the Centers for Disease Control and Prevention. People also experience TBIs from falls, motor vehicle crashes, or assaults.

Implanted neurotechnology can leave users vulnerable when manufacturers go under

Despite providing relief from neurological conditions, patients are left stranded when the companies that make these devices shut down. The lack of regulation means patients often face technical failure, insurance battles, or risky surgeries to maintain their quality of life.

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

An estimated 2 million brain cells die each minute a stroke goes untreated

Modern stroke treatment is a delicate balance between obtaining an accurate diagnosis and delivering treatment quickly. Each stroke has its own cause, and the appropriate treatment must be paired with the correct diagnosis to prevent further harm. Typical treatments pair emergency surgery to relieve the affected area and long-term regimens to avoid recurrence.

Thanatology is the study of death and dying

Watch this video exploring the evolution in how researchers are studying and understanding death in the context of recent scientific research. CPR to restart hearts, ventilators, and other discoveries have challenged the way we think of death and scientifically upended the idea of death as a single moment.

How to repair a baby’s broken heart

A rare disorder that prevents some babies from getting enough oxygen to their organs can be repaired through a series of three intricate surgeries. This article and graphic explain the process behind correcting single-ventricle defects, also known as SVDs.This disorder happens when one of the heart's lower chambers doesn't work correctly, resulting in deoxygenated and oxygenated blood circulating the body rather than just the latter.

After the patient died, a latent pig virus was discovered inside his xenotransplant

Researchers studying the death of David Bennett Sr., the first gene-edited pig heart transplant patient, discovered potential factors that may have contributed to his demise. One finding is that there was a latent virus, called porcine cytomegalovirus (PCMV), in the pig heart, which may have contributed to dysfunction of the transplant.

Open brain surgery is not required for BCIs inserted via blood vessel injection

Synchron's brain-computer interface, the Synchron Switch, takes advantage of preexisting medical devices, such as stents and catheters. Cells grow over the device over a 90-day period, incorporating it into the vessel wall and minimizing clots.

'Blackout challenge' can cause brain damage or death in under 5 minutes

A social media trend that encourages viewers to asphyxiate themselves until they lose consciousness in the hopes of feeling "high" or euphoric has garnered the interest of teens and adolescents, with dangerous results. Variations of this deadly challenge have been adolescent trends every few years.

Some UK doctors pushed for broad 'do not resuscitate' orders for autistic adults during COVID

The controversial push was to create such orders without individuals' or their families' consent, underscoring modern-day prejudice against people on the spectrum.

The evolution of dream science—from interpretation to advanced brain imaging

In the mid-1900s, dream scientists would tape study participants' eyes open, wait for them to fall asleep, and attempt to influence their dreams by shaking, tickling, and more. Now, advanced techniques like MRIs have shed new light on what’s happening in the brain as we sleep.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

AI griefbots are controversial and could conceivably change how we mourn

"Deathbots" or "griefbots" are a particularly controversial use of AI chatbots. Mourners chat with AI chatbots that generate text or even video avatars of the dead based on inputs from loved ones to theoretically provide closure and comfort.

Why vascular dementia develops

This type of dementia, the second most common form after Alzheimer's, develops due to microscopic bleeds and blood vessel blockages in the brain. The condition isn't curable but medications to help with blood clotting and high blood pressure are part of a suite of interventions designed to minimize damage to the brain.

A living will is a legal document spelling out your medical wishes for emergency care

This legal document makes it explicit if you want medical interventions in the event of an emergency, including CPR, feeding tubes, ventilator assistance to push air into your lungs to help you breathe, and more. Talking with your doctor about this is covered by Medicare.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Play 17th-century death roulette

Before modern science and medicine, death was much harder to escape. Using real mortality records from London's Dreadful Visitation–a collection of all the Bills of Mortality from 1665–this interactive game gives you an idea of what may have possibly killed you during the Great Plague. Grow your appreciation for life today as you stumble upon causes of death like “livergrown” and “drowned at St. Katharine’s by the Tower”.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Long-haul COVID: What doctors want patients to know

Long COVID continues to be a medical mystery, but some parts of the puzzle are falling into place. Learn more from intensivist Devang Sanghavi, MD.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

11 people died from firework injuries in the US in 2024.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time