Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

Phantom limbs were first documented in the 16th century by a French military surgeon

Ambroise Paré, the military surgeon, observed this phenomenon among soldiers who'd lost limbs, yet the term wasn't formally coined until hundreds of years later, by Silas Weird Mitchell, an American Civil War surgeon.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

Left versus right brain strokes vary significantly in long-term effects

Due to the high complexity of the brain, the aftereffects of a stroke can have widely different manifestations, ranging from minor temporary impairments to rapid death. Whether a stroke results in paralysis, speech impairments, loss of bodily function, or death will depend on whether it occurs in the left or right hemispheres or the brain stem.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Stem cell therapies show promise in treating spinal injuries

Researchers have long hoped to use stem cells in regenerative medicine to help patients with spinal cord injuries restore sensation and movement. A 2024 clinical trial illustrates how stem cells derived from patients' fat tissue could help spur the creation of new cells in the spinal cord.

Blindfolded people could identify objects by touch alone a week after encountering them

These touch memories are more complex and durable than previously thought. In research published in 2018, blindfolded volunteers touched over 150 household objects for about 10 seconds each, and afterward correctly identified the objects more than 90 percent of the time when presented with the object and a similar one. Participants still knew most of the objects a week later with about 85 percent accuracy. (Some users may experience a paywall.)

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

Listen to the evolving economics of prosthetics

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs. A below-knee prosthetic typically costs $15,000 to $20,000—not counting all the rehab costs.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Is conventional wisdom about amyloid plaques wrong?

Neurobiologist Karl Herrup makes the case for reevaluating current research paradigms and embracing a more comprehensive understanding of Alzheimer's disease. He highlights years of failed clinical trials of drugs reducing amyloid plaques in treating Alzheimer's, the establishment of that theory based on a single patient, and more.

Long-term memory issues among West Nile survivors may be from immune response, not virus

Rodent research suggests that long-term neurological complications such as fatigue, weakness, difficulty walking, and memory loss, may be due to the immune system systematically destroying parts of neurons in the brain in response to the infection, rather than due to viral infection itself.

Humans likely cannot tickle themselves because there's no element of surprise

Unraveling the neural mechanisms of tickling—formally called gargalesis—is an area of active research, but a leading theory about why we can't tickle ourselves is that the brain's somatosensory cortex processes self-touch differently than it does external touch. The cerebellum already anticipated what was going to happen when you move your hand for self-touch, limiting the effectiveness of a self-tickle.

Do trees feel pain?

Trees don’t have nerves or brains. But when they’re wounded, they send underground and airborne warnings to other trees.

What a railroad spike through the head taught science about the brain

In 1848, a railroad worker survived an accident that drove a 13-pound iron bar through his head. The injury changed his personality, and our understanding of the brain.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

The neuroscience of REM atonia disorders, where patients act out dreams

What prevents the typical person from acting out their dreams? Temporary paralysis of skeletal muscles, usually leading up to, and during, REM sleep. This academic article and related graphics explore what happens when this process doesn't go as planned, leading to REM sleep behavior disorder.

The benefits of extreme pain rituals, explained

We naturally avoid pain and see it as a negative experience. But many traditional cultures incorporate extremely painful rituals into their religious ceremonies, claiming they, in fact, provide ample benefits. Researchers were able to observe boosts in happiness and a sense of belonging in a tribe of Mauritians after they undertook a rigorously painful religious ritual. Read about the study here.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Despite being favored by 87% of Americans, Congress does not have term limits.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.