Research suggests the brain maintains connections to lost limbs

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

The findings, published in 2025, traced three amputees' brain-body maps and how they respond to body part movements—both before and after scheduled arm amputations. The unexpected neural stability suggests that the unchanged pathways for the missing limbs may explain why people continue to feel them so acutely.

Brain-reading devices are helping paralyzed people to touch

In clinical trials, implanted brain-computer interfaces are allowing dozens of individuals with paralysis to control prosthetics that are restoring a range of skills, including drinking coffee and feeding oneself. One area of related prosthetic research is creating a synthetic sense of touch—coupling the brain implant with pressure sensors in prosthetic robotic fingertips to enable an approximation of a sense of touch.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

Left versus right brain strokes vary significantly in long-term effects

Due to the high complexity of the brain, the aftereffects of a stroke can have widely different manifestations, ranging from minor temporary impairments to rapid death. Whether a stroke results in paralysis, speech impairments, loss of bodily function, or death will depend on whether it occurs in the left or right hemispheres or the brain stem.

Researchers use the brain's ability to edit memories to explore memory deletion

Scientists have successfully implanted false memories in mice after studying how the editing process works in the brain. Beyond potentially deleting memories in those with PTSD, upcoming research may allow clinicians to forecast the onset of neurodegenerative diseases.

People learned to fly in VR, and their brains then accepted wings as body parts

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts. The brain research has potential implications for how VR training may help people adapt to prostheses. (Free with email.)

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Phantom limbs were first documented in the 16th century by a French military surgeon

Ambroise Paré, the military surgeon, observed this phenomenon among soldiers who'd lost limbs, yet the term wasn't formally coined until hundreds of years later, by Silas Weird Mitchell, an American Civil War surgeon.

Long-term memory formation may not need short-term memory

New research shows that long-term memories can still develop even when short-term memory formation is blocked, suggesting the brain uses separate pathways for short- and long-term memory. This discovery could help scientists open new avenues for treating memory loss in diseases like Alzheimer’s.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

Four in 10 CPR patients report consciousness not captured by standard measures

A recent study found people revived by CPR after cardiac arrest reported they experienced some amount of consciousness during clinical death, suggesting our brains are capable of thought and memory for significantly longer after death than previously thought.

Strength training appears to make for a healthier, youthful-looking brain

A study from 2025 links having higher amounts of muscle with a more youthful-looking brain age. Scientists analyzed data from more than 1,100 healthy adults around their mid-50s after they underwent full-body MRIs, comparing muscle, fat, and brain age appearances from the scans.Their findings link strength training and controlling visceral fat with improved brain health. The research didn't tease apart why this benefit occurs.

If hearing is damaged, the brain may amplify remaining sounds, perhaps causing tinnitus

Recent mouse brain and ear imaging revealed that the creature compensates for hearing loss by sending signals to the cochlea in the inner ear. This triggers nerve fibers in the inner ear to increase volume and become more sensitive. Learning about these boosted-sensitivity messages from the brain to the cochlea—if they're similar in humans—might help explain tinnitus and fuel experimental approaches to turn down that sensitivity.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Playing music enhances the creation, storage, and retrieval of memories

Scans of the brains of individuals who play instruments have shown enhanced connectivity between multiple brain regions—visual, auditory, and motor cortices—and the corpus callosum, which connects the two brain hemispheres. These complex connections are strengthened through practice and then used in other activities that involve both logic and creativity. The brains of musicians also appear to give experiences multiple types of memory tags, such as audio, emotional, and conceptual, improving their processing.

Explore an interactive 3D model of the brain

The brain contains about 86 billion neurons—nervous system cells—and controls vital bodily functions via electrochemical signals. Neurons form circuits through axons, and different brain regions use these circuits to perform specific tasks.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Blindfolded people could identify objects by touch alone a week after encountering them

These touch memories are more complex and durable than previously thought. In research published in 2018, blindfolded volunteers touched over 150 household objects for about 10 seconds each, and afterward correctly identified the objects more than 90 percent of the time when presented with the object and a similar one. Participants still knew most of the objects a week later with about 85 percent accuracy. (Some users may experience a paywall.)

Leprosy doesn't cause fingers or toes to fall off

The nerve damage that results from infection sometimes causes loss of feeling in extremities so injuries like cuts or burns may be missed. In such cases, resulting infections can lead to digit loss. Fingers or toes can also appear to shorten with this disease because nerve damage can sometimes make muscles in fingers and toes so weak that they're reabsorbed by the body.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

Like fingerprints, brain anatomy is unique too

Researchers have discovered that a combination of experiences and genetic factors shape the anatomy of the human brain. They found even quick experiences affect the brain’s genetic makeup, which—over time—means every person develops a completely unique brain anatomy. While brain imaging could be used to identify individuals, it remains much more expensive than fingerprinting for now. Read to found out more about this study from the University of Zurich.

Déjà vu is a memory illusion involving brain regions correcting inaccurate memories

Neuroscientists suggest the phenomenon is your brain recognizing that this feeling of familiarity is incorrect, showing off the brain's internal fact-checking system. Younger people experience déjà vu more often because their brains have higher excitatory activity and stronger memory monitoring systems.

Several brain regions are involved in lucid dreaming

Some scientists propose that lucid dreaming may require the emergence of a brain network, which is when multiple brain regions collaborate to perform certain functions. Research shows that lucid dreaming is associated with increased activity in the frontal lobes—associated with decision-making, voluntary movement, attention management, and more.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Tattoos remain visible on your skin thanks to immune cells called macrophages

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

See a 3D reconstruction of Tenochtitlan, the Aztec capital that was home to an estimated population of 200,000 to 400,000.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.