The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

People learned to fly in VR, and their brains then accepted wings as body parts

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts. The brain research has potential implications for how VR training may help people adapt to prostheses. (Free with email.)

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Phantom limbs were first documented in the 16th century by a French military surgeon

Ambroise Paré, the military surgeon, observed this phenomenon among soldiers who'd lost limbs, yet the term wasn't formally coined until hundreds of years later, by Silas Weird Mitchell, an American Civil War surgeon.

Left versus right brain strokes vary significantly in long-term effects

Due to the high complexity of the brain, the aftereffects of a stroke can have widely different manifestations, ranging from minor temporary impairments to rapid death. Whether a stroke results in paralysis, speech impairments, loss of bodily function, or death will depend on whether it occurs in the left or right hemispheres or the brain stem.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

We can sense touch even through a tool

Research published in 2019 indicates that the same brain regions involved in sensing touch on the body also process it when humans use a tool to do the touching. Essentially, it's acting as a sensory extension of the body. (Some users may experience a paywall.)

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Listen to the evolving economics of prosthetics

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs. A below-knee prosthetic typically costs $15,000 to $20,000—not counting all the rehab costs.

Visualize the difference between a healthy brain and one with Alzheimer's

The brain has three main parts—the cerebrum, brain stem, and cerebellum—each combining to control the entirety of the body's operations. Alzheimer's progressively deteriorates the circuitry in these structures, resulting in what we see as the symptoms of the disease.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Stem cell therapies show promise in treating spinal injuries

Researchers have long hoped to use stem cells in regenerative medicine to help patients with spinal cord injuries restore sensation and movement. A 2024 clinical trial illustrates how stem cells derived from patients' fat tissue could help spur the creation of new cells in the spinal cord.

How does the body know where it is in space?

Close your eyes and touch your nose. How did you know where your nose was? How could you tell where your hand was? That's proprioception, the sense that keeps your brain apprised of the body's position and movement. This article explains how this sense works, what happens when people don't have it, and what we know about it.

If hearing is damaged, the brain may amplify remaining sounds, perhaps causing tinnitus

Recent mouse brain and ear imaging revealed that the creature compensates for hearing loss by sending signals to the cochlea in the inner ear. This triggers nerve fibers in the inner ear to increase volume and become more sensitive. Learning about these boosted-sensitivity messages from the brain to the cochlea—if they're similar in humans—might help explain tinnitus and fuel experimental approaches to turn down that sensitivity.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Why do dreamers twitch?

This thought-provoking piece highlights newer research suggesting sleep twitches may not be random dream leftovers, but instead a crucial way our brains map and understand our bodies. From sleeping rat pups to dreaming octopi, this biological mapping system appears universal across animal species.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

What a railroad spike through the head taught science about the brain

In 1848, a railroad worker survived an accident that drove a 13-pound iron bar through his head. The injury changed his personality, and our understanding of the brain.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

MS can damage the brain up to 7 years before symptoms appear

Recent research scouring blood samples from 134 people with MS, both before and after their diagnosis, found that about seven years before these patients were diagnosed, there was a spike in a protein called myelin oligodendrocyte glycoprotein—indicating disease-associated damage to the protective myelin around nerve fibers.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.