Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Traumatic brain injury is a leading cause of brain death—and TBIs are trending up

Traumatic brain injury-related deaths have generally increased between 2000 and 2023, growing from roughly 49,000 to more than 68,000 in 2023. Firearm-related suicide is the most common cause of TBI-related deaths in the US, according to the Centers for Disease Control and Prevention. People also experience TBIs from falls, motor vehicle crashes, or assaults.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

See the global blindness burden by cause and continent.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

This Texas city is having an 'amputation crisis'

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

America's top causes of death are heart disease, cancer, accidents, and stroke

Heart disease killed more than 680,000 people in 2023 and cancer killed around 613,000 people that year. Both causes of death are far above the next leading cause of death—accidents, which numbered around 223,000. Provisional data for 2024 indicates the leading causes of death remained the same.

See what regions report new leprosy cases

This graphic shows the burden of leprosy by region for 2023, based on data provided from the World Health Organization, which collates this information. Southeast Asia leads in the number of cases by region. (Some readers may experience a paywall.)

Firework or sparkler burns can have large effects on our hands' range of motion.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

The US had about 155.4 million emergency room visits in 2022, and more than a third involved injuries, including poisonings.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

11 people died from firework injuries in the US in 2024, with most of those deaths involving misuse of the explosives and device malfunctions or misfires.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic images.)

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

One in 10 adults worldwide has diabetes.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

World health experts expect more than 240 million global cases of AMD in 2030

The World Health Organization estimated in 2019 that by 2020 there would be roughly 195.6 million cases of age-related macular degeneration and projected that the number would continue to grow. (Some users may experience a paywall.)

See how anxiety disorder rates vary across 200+ countries, with Portugal, Brazil, and Iran reporting the highest burdens.

China reports the highest prevalence of hearing loss and South Africa reports the lowest

This conclusion comes from research published in 2025 that analyzed self-reported hearing loss and hearing aid use from long-term studies that covered 28 countries. Its findings included that the countries with the greatest prevalence of hearing loss (China, South Korea, Mexico, and Brazil) also had the lowest levels of hearing aid use.

A stroke occurs when blood flow to part of the brain is suddenly interrupted, either by a blockage (ischemic stroke) or bleeding when a blood vessel in the brain breaks and bleeds (hemorrhagic stroke).

Fireworks-related ER visits in 2024 increased by 52% as compared to the prior year.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

US macular degeneration burden is based on statistical modeling and Medicare claims

Prevalence estimates for age-related macular degeneration in the US are usually based on the Vision and Eye Health Surveillance System. Disease numbers are generated using Bayesian meta-regression (a type of statistical modeling), which pulls together information from multiple sources, including Medicare claims.

More than 5% of the world's population has disabling hearing loss

Disabling hearing loss is defined as hearing loss greater than 35 decibels in the better hearing ear. (For context, that means the sound of leaves rustling, at roughly 30 decibels, would be inaudible even to your better-hearing ear.) The World Health Organization's data suggests that more than 5% of the world's population has this level of loss requiring rehabilitation, which amounts to 430 million people—including 34 million children.

See the data comparing healthcare worker violence with other industries pre-pandemic

Nonfatal workplace violence against healthcare workers steadily climbed each year even before the pandemic. Healthcare workers comprised 73% of all nonfatal workplace injuries and illnesses due to violence in 2018. The violence was highest among psychiatric and substance abuse hospitals.

Someone suffers from a stroke every 40 seconds

Every 40 seconds, someone in the US experiences a stroke—and every minute without treatment destroys millions of brain cells. This explainer breaks down the two main types of strokes, their risk factors, and how early detection could change outcomes in the future.

See worldwide hearing loss by age group and country

This 2023 data from the Institute for Health Metrics and Evaluation shows the estimated number of people with complete hearing loss in different age groups per 100,000 people in the population. Individuals aged 70 or older make up the largest group with this type of hearing deficit.