See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person’s life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

This Texas city is having an 'amputation crisis'

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

An experimental bionic knee has been directly integrated into the user's muscle and bone—not an external socket—marking a significant prosthetic advancement.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

Exploring the link between history, art, and anatomy

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

The surgeon who tried to save John Lennon says he can’t forget that night

Frank Veteran was a resident in 1980 on the night John Lennon was shot in New York. For years afterward, he tried to process the sight of seeing the Beatle dying in the hospital, including through art, but he says that the memories from the experience are still vivid.

Watch this video letter (via Facebook) from a kidney recipient to his donor

A kidney recipient named Justin reads a letter he wrote to his deceased donor about how the person's generous kidney donation saved his parents from having to watch him suffer and his brother from having the pressure of perhaps being his only shot at a life-saving transplant.

Medical imaging allows 3D printers to create patient-matched devices

With imaging data on a person's anatomy, external prostheses and implants, such as cranial plates or hip joints, can be custom-printed to better match a patient's body. Fabrication of porous structures can promote bone growth, leading to longer-lasting implants.

This Indiana medical school encouraged students to get to know their cadavers' families

The school's anatomy professor instructed medical students to think of the cadavers they worked with as their "first patients"—using their names to acknowledge that this was a person and to exchange letters with the cadaver's family members if they agreed to participate. At the conclusion of the course, families were invited to a lab-based memorial service.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

See images of medical cases of firework injuries shared on this 'Instagram for doctors'

Included photos include scans of missing or damaged digits, a chunk of missing flesh, a facial injury from a homemade firework in a glass bottle that exploded in the patient's hand before it was thrown, and an injury where a patient's finger bone flew into someone's leg.

Why Men's Legs Were Everything

From codpieces to cotton hose, here's the surprisingly loaded history of men's legs, and why 18th-century Europe couldn't stop staring at them.

See haunting images of the plaster casts of Pompeii’s victims

The plaster casts preserve victims’ final moments in striking detail—from their poses to the expressions frozen on their faces. This piece explains how 19th-century archaeologist Giuseppe Fiorelli devised the method long after the bodies had decomposed.

Whose bodies are held inside the American Museum of Natural History?

The American Museum of Natural History holds the remains of at least 12,000 people collected via purchase, donation, or expedition. This article by a professor of art crime details their attempt to identify the individuals whose remains the museum held. Amid questioning, AMNH announced it would change its human remains policy. At the time of the article's publication in October 2023, AMNH had few human remains on public display.

The subjectivity of pain means that one person's kidney stones may be another's childbirth, but most sources of pain do have objective, underlying causes.

Key components of a joint: bones, cartilage, ligaments, tendons, and fluid

A human joint is any place in the human body where two bones connect. This junction allows for movement, but is prone to breakdown and pain. This nine-minute video explains normal joint anatomy and function, with particular attention to the different types of motion each joint facilitates.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

Why surgeons implant teeth into eyes

What if the thing that restored your vision… was your own tooth? That’s exactly what happened to Brent Chapman. After 20 years without sight, a bizarre surgery using his tooth as a lens restored his vision.

Lee Spencer, a single-leg amputee, broke the world record when he rowed solo and unsupported across the Atlantic Ocean in 2019.

Leprosy doesn't cause fingers or toes to fall off

The nerve damage that results from infection sometimes causes loss of feeling in extremities so injuries like cuts or burns may be missed. In such cases, resulting infections can lead to digit loss. Fingers or toes can also appear to shorten with this disease because nerve damage can sometimes make muscles in fingers and toes so weak that they're reabsorbed by the body.

The origin story of the Paralympic movement and its founder, Dr. Ludwig Guttmann

Dr. Ludwig Guttmann, the founder of the Paralympic movement, revolutionized the treatment of spinal injuries. His belief in the power of sports for rehabilitation led to the creation of the Paralympic Games, now celebrated every Olympic year. This in-depth article from The History Press details the life and achievements of Dr. Guttmann, and includes historical photos and videos of the veterans-turned-athletes whose lives he changed.

The anatomy of 'Mashle,' as described by a doctor

"Mashle: Magic and Muscles" is a manga and anime in which a seemingly magicless man performs outsized feats he blames on "muscle magic." In this 15-minute video, a doctor breaks down the anatomy and biomechanics of some of the feats performed by Mash, the series' main character who's spotted flying a broom via leg pumping and reading magical texts while sitting in an invisible chair (i.e., single-leg squat).

Inside the world's largest two-headed calf collection

The Two-Headed Calf MOOseum in San Francisco contains 50 taxidermied cow heads, all of which are paired with another one. They are the result of rare genetic mutations called polycephaly, that is, two-headedness. The museum is run by punk musician Henry Rosenthal, who first became captivated by the rare phenomenon in his 20s. Learn more about the exhibit here.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

A young Basquiat was fascinated by the book 'Gray's Anatomy'

At 7 years old, Basquiat was hit by a car while playing stickball. While in the hospital, his mother gave him a copy of Henry Gray’s medical reference book “Gray’s Anatomy” to help him better understand his recovery. The book fascinated the young Basquiat, who’d later incorporate bodies and anatomy into his art.

Six-year-old boy in wheelchair surprises his family by walking at his graduation

The young boy was diagnosed with Noonan syndrome, a rare genetic disorder that impacts mobility and development, at just 2 months old. He usually needs a wheelchair or walker to get around, but he shocked and thrilled his parents by standing up to receive his kindergarten diploma.

3 US maps illustrate transplants, donors, and organ waitlist additions—by state

National UNOS tracking data feeds into these US maps that record all the transplants, donors, and waitlist additions in the last 12 months. California, for example, had the most transplantations in 2025—totaling about 5,200—but it also has the longest waiting list, with more than 20,000 additions in that same period.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

After the patient died, a latent pig virus was discovered inside his xenotransplant

Researchers studying the death of David Bennett Sr., the first gene-edited pig heart transplant patient, discovered potential factors that may have contributed to his demise. One finding is that there was a latent virus, called porcine cytomegalovirus (PCMV), in the pig heart, which may have contributed to dysfunction of the transplant.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Look through this WWI stretcher bearer's bag

While it was indeed the first industrialized war, medical science had yet to catch up on the battlefield. This nearly eight-minute video sorts through the contents of a World War I stretcher-bearer's satchel. A modern doctor and ex-officer assesses the bag's various medical tools for performing first aid on the battlefield.

In 1939, baseball star Lou Gehrig delivered his 'Luckiest Man' speech after retiring due to a health condition

Gehrig's diagnosis of amyotrophic lateral sclerosis, a disease that now bears his name, forced him to retire early. Weeks later, he spoke with gratitude and stated, "For the past two weeks, you have been reading about a bad break. Yet today I consider myself the luckiest man on the face of the earth." Gehrig died at the age of 37, about two years later.

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Organ donation isn't usually logistically possible if you die at home

Since organs need to be well-preserved for organ donation, with oxygen flowing through the body, internal organs often aren't viable for organ donation if someone dies at home. But some tissues—like eye corneas and skin tissue—may still be donated since they remain usable for a longer period without oxygen flow.

The Bone Wars turned paleontology into a rivalry fraught with public scandal

Othniel Charles Marsh and Edward Drinker Cope were friends-turned-enemies competing for the glory of discovering dinosaurs. It became so intense that when Cope died, he donated his body to science to prove he had a bigger brain than Marsh.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Families of true crime victims deal with added pain when their stories are publicized

True crime enthusiasts have never asked Annie Nichol to consent to public recountings of her sister's murder. For decades, Nichol has been inundated with gruesome dramatizations of one of life's greatest losses by people who profit from such productions. She has, however, been asked to share memories of her sister, though such memories "are all that I have left of her that haven't been exploited for public consumption."

O’Keeffe collected animal skulls and bones for her art

O’Keeffe used bones as motifs in her work throughout her time in New Mexico. She famously stated, “The bones do not symbolize death to me. They are shapes that I enjoy … They're very lively.”

A comprehensive review of BPC-157 studies identified no human safety data

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).