The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Read the 1866 story in The Atlantic that put phantom limbs on the map, a fictional story by a Civil War surgeon that was mistaken for being a true account by many readers.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

Learn how a doctor successfully treated a patient's phantom limb pain with a mirror, tricking his brain into thinking his still-present arm was the missing paralyzed left one.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

19th-century Americans used technology to try to prove the existence of ghosts

In the 19th century, following technological advancements like the telegraph, phonograph, and others, efforts were made to capture proof of ghosts. These technologies seemed supernatural in their own right and emerged at the same time Spiritualism took off in the US, resulting in new approaches to connecting with the dead.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

The oldest medical report of a near-death experience dates to around 1740.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

The word 'vampire' appeared in the English-speaking world in the 1730s

However, earlier mentions of creatures with similar characteristics existed throughout Medieval Europe. For example, people often spoke of revenants—restless dead creatures who tormented the living. Historians believe these stories grew in popularity in part because of influence from the Catholic Church, which was emphasizing the idea of purgatory. These older revenant stories eventually influenced modern vampire folklore.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

Synesthesia: when sensation in one sense triggers an unrelated sense in the brain

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical.

Thomas Edison, eager to communicate with ghosts, tinkered with an apparatus called the 'spirit phone.'

Twain claimed to possess 'mental telegraphy'

In an 1891 essay, the writer claimed to possess psychic powers. It’s something that seemingly supported by his mother and his own death: Twain predicted he would die the day after Halley’s Comet returned in 1910, which did indeed happen.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

Brain-reading devices are helping paralyzed people to touch

In clinical trials, implanted brain-computer interfaces are allowing dozens of individuals with paralysis to control prosthetics that are restoring a range of skills, including drinking coffee and feeding oneself. One area of related prosthetic research is creating a synthetic sense of touch—coupling the brain implant with pressure sensors in prosthetic robotic fingertips to enable an approximation of a sense of touch.

Former American President Abraham Lincoln is one of history’s most famous ghosts

Abraham Lincoln, Anne Boleyn, Pausanias, and the Maharajah Duleep Singh are just a few of the notable phantoms found around the world. Several White House occupants and visitors have claimed to see Lincoln, including Theodore Roosevelt, Grace Coolidge, and Winston Churchill.

Ray Bradbury said he was inspired to pursue writing after meeting a magician named Mr. Electrico, but scholars have never been able to confirm the story.

Peptide research dates back to the late 1800s

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

Pilates was invented by an acrobatic WWI prisoner of war

As the Great War raged on, and as months gave way to years, the imprisoned Joseph Pilates explored a question that he had pondered since childhood: Could he reimagine the capabilities of the human body through an anatomically based method of training, taking inspiration from scientific treatises, the carefree movement of children, and the dexterous ease of cats? Read this article to learn about the birth and legacy of Pilates.

Ghosts can work as powerful literary devices

Noteworthy American novels like Toni Morrison’s "Beloved" tell us how spirits help deliver information and greater truths unknown to the characters. Wondering about our souls is common in literature, and the phantoms in these tales offer a unique way of contemplating the complicated experience of being human.

Exploring the link between history, art, and anatomy

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

Salvador Dalí believed he was his own dead brother.

Dalí's parents found the miracle of his birth nine months after his brother died to be profound, telling him he was his brother's reincarnation. Dalí carried this belief into his adult life and often cited its deep influence on him, including his preoccupation with death and mortality.