The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

In the 19th century, following technological advancements like the telegraph, phonograph, and others, efforts were made to capture proof of ghosts. These technologies seemed supernatural in their own right and emerged at the same time Spiritualism took off in the US, resulting in new approaches to connecting with the dead.

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

However, earlier mentions of creatures with similar characteristics existed throughout Medieval Europe. For example, people often spoke of revenants—restless dead creatures who tormented the living. Historians believe these stories grew in popularity in part because of influence from the Catholic Church, which was emphasizing the idea of purgatory. These older revenant stories eventually influenced modern vampire folklore.

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

In an 1891 essay, the writer claimed to possess psychic powers. It’s something that seemingly supported by his mother and his own death: Twain predicted he would die the day after Halley’s Comet returned in 1910, which did indeed happen.

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

Abraham Lincoln, Anne Boleyn, Pausanias, and the Maharajah Duleep Singh are just a few of the notable phantoms found around the world. Several White House occupants and visitors have claimed to see Lincoln, including Theodore Roosevelt, Grace Coolidge, and Winston Churchill.

As the Great War raged on, and as months gave way to years, the imprisoned Joseph Pilates explored a question that he had pondered since childhood: Could he reimagine the capabilities of the human body through an anatomically based method of training, taking inspiration from scientific treatises, the carefree movement of children, and the dexterous ease of cats? Read this article to learn about the birth and legacy of Pilates.

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

Noteworthy American novels like Toni Morrison’s "Beloved" tell us how spirits help deliver information and greater truths unknown to the characters. Wondering about our souls is common in literature, and the phantoms in these tales offer a unique way of contemplating the complicated experience of being human.

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

The plaster casts preserve victims’ final moments in striking detail—from their poses to the expressions frozen on their faces. This piece explains how 19th-century archaeologist Giuseppe Fiorelli devised the method long after the bodies had decomposed.

Dalí's parents found the miracle of his birth nine months after his brother died to be profound, telling him he was his brother's reincarnation. Dalí carried this belief into his adult life and often cited its deep influence on him, including his preoccupation with death and mortality.

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

At the Bicêtre Hospital, an asylum near Paris, Jean-Baptiste Pussin (who had previously been a patient but later led the hospital administration) tried to hire as many staff as possible from among recovered patients. Chief physician Philippe Pinel found these individuals to be kinder than other staff and "averse from active cruelty" which was common at the time. This approach allowed the facility to move away from shackling patients and other violent methods.

While it was indeed the first industrialized war, medical science had yet to catch up on the battlefield. This nearly eight-minute video sorts through the contents of a World War I stretcher-bearer's satchel. A modern doctor and ex-officer assesses the bag's various medical tools for performing first aid on the battlefield.

This phenomenon was measured in a 2018 study that examined the prevalence and risk factors for phantom odor perception. Older adults were less likely to experience these phantom odors as they age, just as their overall sense of smell declines. Women are more likely than men to perceive phantom odors.