Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Learn how a doctor successfully treated a patient's phantom limb pain with a mirror, tricking his brain into thinking his still-present arm was the missing paralyzed left one.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

Thomas Edison, eager to communicate with ghosts, tinkered with an apparatus called the 'spirit phone.'

William Mumler’s spirit photography stunned and bewildered the public

William Mumler’s most famous work is a portrait of Mary Todd Lincoln accompanied by the ghost of her deceased husband, Abraham Lincoln. Other subjects of Mumler's photos claimed that the spirits standing beside them resembled their loved ones. Mumler’s method was never officially proven and continues to mystify viewers.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Ray Bradbury said he was inspired to pursue writing after meeting a magician named Mr. Electrico, but scholars have never been able to confirm the story.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Ghosts can work as powerful literary devices

Noteworthy American novels like Toni Morrison’s "Beloved" tell us how spirits help deliver information and greater truths unknown to the characters. Wondering about our souls is common in literature, and the phantoms in these tales offer a unique way of contemplating the complicated experience of being human.

Twain claimed to possess 'mental telegraphy'

In an 1891 essay, the writer claimed to possess psychic powers. It’s something that seemingly supported by his mother and his own death: Twain predicted he would die the day after Halley’s Comet returned in 1910, which did indeed happen.

19th-century Americans used technology to try to prove the existence of ghosts

In the 19th century, following technological advancements like the telegraph, phonograph, and others, efforts were made to capture proof of ghosts. These technologies seemed supernatural in their own right and emerged at the same time Spiritualism took off in the US, resulting in new approaches to connecting with the dead.

Lee Spencer, a single-leg amputee, broke the world record when he rowed solo and unsupported across the Atlantic Ocean in 2019.

Former American President Abraham Lincoln is one of history’s most famous ghosts

Abraham Lincoln, Anne Boleyn, Pausanias, and the Maharajah Duleep Singh are just a few of the notable phantoms found around the world. Several White House occupants and visitors have claimed to see Lincoln, including Theodore Roosevelt, Grace Coolidge, and Winston Churchill.

In 1842, a 'mermaid' from Fiji was put on display at a museum, drawing large crowds and fooling many. It was later discovered that the creature was created by sewing the upper body of a monkey to the lower body of a fish.

Mark Twain once challenged a rival newspaper editor to a duel

While writing for a newspaper in Virginia City, Nevada, Twain published a story about a local fundraiser, accusing the paper’s rival of rescinding their donation. The problem was that the story was untrue: It was a hoax that he had concocted while drunk. The affair led to a protracted, public back-and-forth, with Twain challenging the editor of the rival paper to a duel; likewise, two other men challenged Twain to a duel. Twain ultimately left town, but wrote about the episode later on in an essay titled “How I Escaped Being Killed in a Duel.”

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

'Moby-Dick' was inspired by a real whale named Mocha Dick.

Read an excerpt from 'The Immortal Life of Henrietta Lacks,' the story of the Black woman whose nonconsensually sampled cancerous cells underpin thousands of research papers and several Nobel Prize-winning works.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

How Emily Dickinson and Walt Whitman grappled with the American Civil War

Whitman, whose brother was injured while fighting for the Union, was often overt in his pro-Union poems. Dickinson, whose brother paid to have someone enlist under his name, was more subtle, though equally as affected, as this comparative analysis makes clear.

The ghost of Bobby Dunbar

In 1912, a four-year-old Louisiana boy went missing for eight months. Contemporary accounts differed in his mother's reaction upon seeing him; some claimed she was overjoyed, others that she didn't recognize him. Shortly after, a second woman claimed the child was hers, though he remained with the first woman. In 2004, DNA analysis determined the child had not been related to the family, suggesting the kidnapping was never solved.

This Indiana medical school encouraged students to get to know their cadavers' families

The school's anatomy professor instructed medical students to think of the cadavers they worked with as their "first patients"—using their names to acknowledge that this was a person and to exchange letters with the cadaver's family members if they agreed to participate. At the conclusion of the course, families were invited to a lab-based memorial service.

President Abraham Lincoln was inspired by a novel to create the holiday

A writer and abolitionist from New Hampshire, Sarah Josepha Hale was instrumental in cementing many of the Thanksgiving traditions we celebrate today. Her 1852 novel "Northwood, a Tale of New England," described a feast with a roasted turkey, stuffing, plum pudding, and pumpkin pie. She wrote dozens of editorials and letters to politicians campaigning for the day to become a national holiday. In 1863 she was finally successful in convincing President Lincoln to make it official.

He made a name with a short story about jumping frogs

Twain’s first big break came with “Jim Smiley and His Jumping Frog,” a fictitious story that appeared in a 1865 edition of the New York Saturday Press. (When it was republished elsewhere, the title was changed to “The Celebrated Jumping Frog of Calaveras County.”) That year, American poet James Russell Lowe called it “the finest piece of humorous literature yet produced in America.”

Whitman led a Lincoln lecture late in life

Whitman toured several cities with “The Death of Lincoln,” a lecture series about the slain president that sought to establish him as a crucial figured in American history. The talks attracted famous figures, including Mark Twain and General William Tecumseh Sherman.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.