Hear about life as an amputee and how mirror box therapy helped.

Learn how a doctor successfully treated a patient's phantom limb pain with a mirror, tricking his brain into thinking his still-present arm was the missing paralyzed left one.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Non-amputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Using brain implants to restore vision

Several companies are attempting to create brain-computer interfaces that skip over retinas and optic nerves to allow visual input to go straight to the brain, potentially restoring some sight to the blind. Clinical trial findings suggest restored sight is sparse and manifests differently than a sighted person might expect, appearing as specks of "light" clusters called phosphenes to help differentiate one's surroundings.

Wearing a 'schizophrenia simulator,' designed to build empathy for patients, CNN's Anderson Cooper finds he struggles to function

Donning headphones that play a track mimicking the auditory hallucinations common in schizophrenia, Cooper finds he is very distracted, disconcerted, and frustrated. The auditory track aims to help listeners build empathy with patient populations by understanding the challenges they face in daily life.

Watch patient stories describing life with macular degeneration

This video series features patients discussing their experiences with the disorder, family members describing caregiving, and other insights about the disease.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

Watch veterans experience psilocybin at a Mexican clinic and discuss the aftermath

This "60 Minutes" episode from 2025 follows nine veterans attending a week-long psychedelic retreat to treat their PTSD. Most of the vets say the experience at the Mexican clinic was life-changing. But results were mixed: One veteran reported he was scared and that the experience worsened his mental health overall.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Turning a profit with terminal illness

After Amanda Riley was diagnosed with cancer, her social media followers rallied to raise funds to ensure their favorite religious influencer could afford one miracle after another. As more than $100,000 of donations poured in, Riley shared glimpses into her health struggles, posting evidence as fake as her diagnosis. Pulling from years of journalistic investigation, this eight-episode podcast series dives into Riley's reality.

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

The potential of virtual reality in healthcare

Virtual reality (VR) is carving new frontiers in healthcare, from aiding in stroke recovery to training medical professionals. This article in Time Magazine highlights the innovative uses of VR in medical settings, including its potential and current limitations.

See images of medical cases of firework injuries shared on this 'Instagram for doctors'

Included photos include scans of missing or damaged digits, a chunk of missing flesh, a facial injury from a homemade firework in a glass bottle that exploded in the patient's hand before it was thrown, and an injury where a patient's finger bone flew into someone's leg.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

Learn about the point of the physical and emotional experience of pain, which has three broad categories that help determine treatment approaches.

Can brain scans help with processing trauma?

MRIs and brain monitoring therapies are becoming increasingly popular for those looking to process trauma and address mental health conditions, including PTSD and depression. This article details how these therapies quantify mental health, giving users another way to measure and manage their mental and emotional needs through brain mapping and other methods.

A 1992 failed parachute test provided the hardware for the first mixed reality system

The Virtual Fixtures platform was developed to improve human dexterity by merging physical and virtual objects with haptic feedback from an upper-body exoskeleton. Tight budgeting and significant equipment needs nearly canceled the project, were it not for salvaging and repairing cameras and sensors from a smashed experimental parachute rig.

Meeting someone with common healthcare challenges can be life-changing

The understanding that comes from meeting others who have similar experiences can provide hope that life can get better, the solace of affirmation, and make navigating a new diagnosis or a rare illness, in particular, much easier.

Prosthetics and orthotics have been 3D printed to improve the lives of animals

Shells for hermit crabs, wheelchairs for guinea pigs and dogs, and horseshoes for improved running performance have been created using 3D printers. Other artificial body parts made using this technology include a jaw for a loggerhead turtle, a beak for a toucan, and a tail for an American alligator.

Social support plays a critical role in recovery from addiction

This engaging TEDx talk from addiction researcher Jacki Hillios explores addiction recovery through a transformative lens and Phoenix Multisport—an innovative program helping people rebuild their lives through active lifestyles. By living out its core message that people are not defined by their disease, the program demonstrates the power of social support in recovery.

A novel tinnitus therapy, called Lenire, involves mild electric tongue shocks and sound exposures.

What happens when you can't trust your therapist?

When Marty Markowitz first stepped into his new psychiatrist's office, he triggered a three-decade spiral of abuse that robbed him of his autonomy, relationships, and wealth. Markowitz isn't the only client to lay allegations of abuse at the feet of Dr. Isaac “Ike” Herschkopf, an accomplished New York practitioner with a rolodex of celebrity clients who has since lost his license to practice.

Listen to how medical error affected an emergency physician's approach

Emergency physician Dr. Sarah Gray discusses her worst medical error, what she learned from it, and how medical error and the culture around it lead to physician burnout. In addition to lawsuits, medical errors can lead to guilt, shame, anxiety, and fears of embarrassment, so this podcast discusses how sharing such errors and teaching about them can improve care.

The anechoic chamber at Bell Labs absorbs 99.999% of created sound

The space nearly eliminates sound wave reflection, allowing visitors to become aware of noises created by their own bodies, including their heartbeat and skeletal conduction. Experiments inside have contributed to the development of digital audio and phone touch tones.

Lee Spencer, a single-leg amputee, broke the world record when he rowed solo and unsupported across the Atlantic Ocean in 2019.

Listen to what it was like living as a medieval leper

This podcast uses paleopathological and anthropological findings to reconstruct what it was like for people diagnosed with leprosy in medieval times on the Eurasian continent. If a town lacked a leprosarium—an isolated leper asylum or colony—or the suspected leper was a foreigner or a Jew, which would make them ineligible for leprosarium admission, they'd be expelled.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

A BPPV patient describes how a neck massage fueled crippling vertigo

The pressure, she says, dislodged tiny crystals in her inner ear that are crucial to balance. The condition is called benign paroxysmal positional vertigo, or BPPV.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

The journalist who let AI speak with his voice

Journalist Evan Ratliff became the object of his own story: He opted to clone his voice, feed it into an AI chatbot, and have it do the talking. What could seem like a fun experiment ended up revealing just how far the capacity of artificial intelligence can go in imitating our identities. Hear the ins and outs of how Ratliff achieved this in this fun and thought-provoking episode.

Steve Jobs tried to treat his cancer with alternative medicine

After Steve Jobs was diagnosed with pancreatic cancer, he reportedly restricted his diet to just fruits or just fruits and vegetables, tried out hydrotherapy, and consulted psychics. There’s compelling evidence about the impact of alternative medicine on cancer patients.

Particle beams can be used to alter the surface properties of artificial joints

Surface hardening and embedding specific elements or coatings can improve the biocompatibility and bone tissue integration of these implants. Particle accelerators are significant sources of the radioisotopes needed in medical diagnostics, and microwave linear accelerators are used in the majority of cancer irradiation treatments.

Afterlife traditions help some humans process death

Watch this video discussing concepts of the afterlife presented through an anthropological lens about one family's experience and traditions passed down from one generation to another.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

'Heroes always have their scars. Some you can see, some you read about later on.'

- Boxer George Foreman (1949 - 2025)

Therapy & intimacy in the age of Twitch.

There are thousands of people streaming for single digit audiences. We asked them what it’s like, and the steps they’ve taken to grow their audiences.

Who were the mirror-bearers of ancient Mayan civilization?

The Mirror-Bearer is a remarkable example of Early Classic Maya art, one of many discovered that were crafted from solid hardwood around 500 CE. The male figure is adorned in a knee-length woven skirt and shawl and once held a removable plaque, likely a mosaic mirror. It is a model of an actual Mirror-Bearer, likely a royal court dwarf, and depicts typical Maya courtly scenes. Learn more about the sculpture and its inspiration here.

The Armamentarium is a set of new gene therapy tools to fight brain diseases

Research from 29 universities and institutions across North America has resulted in the development of 1,000 tools that provide large-scale, cell-type specific targeting for the first time. These tools may be used to alter the activity of brain cells to address some neurological diseases and sleep disorders.