The subjectivity of pain means that one person's kidney stones may be another's childbirth, but most sources of pain do have objective, underlying causes.

Learn about the point of the physical and emotional experience of pain, which has three broad categories that help determine treatment approaches.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Explore the biology of pain and why the experience of pain may differ widely from one person to another.

A famous philosophical question asks would you opt for a life with no pain—but without reality.

Your favorite music can minimize physical pain, according to a 2025 study on how music can bring solace and address pain.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Overuse of opioids can lead to hypersensitivity to pain.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

Food poisoning can sometimes cause serious long-term health issues

Although foodborne illness can be relatively mild and cause short-term discomfort, more rarely it can also cause long-term severe health consequences, depending on your individual risk factors, the severity of your sickness, and the care you receive. Kidney failure is one serious complication associated with certain types of food poisoning. Meningitis, hepatitis, arthritis, and pancreatitis are also rare and serious foodborne illness complications. If a pregnant person gets food poisoning, it can cause health issues for the fetus.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

Dengue is sometimes called 'breakbone fever' because it's so painful

Though this mosquito-transmitted disease can be asymptomatic, in more severe cases patients experience high fever, muscle spasms, and joint pain. The experience can be so excruciating that it feels like the patient's bones are broken, thus the nickname of breakbone fever. It's the world's fastest spreading tropical disease.

Mosquitoes top the ranking of the world's deadliest animals

Mosquitos kill about 760,000 people every year. The vast majority of those deaths are caused by malaria, which is transmitted and spread by the Anopheles mosquito. The second-place deadliest animal title goes to snakes, with an estimated human death toll of around 100,000 annually.

Where you fall on the sports misery index

Only one team can win it all each season, which means the majority of fans are disappointed. This bot mines the data on how your teams have performed in recent years and measures your misery index (the higher, the more miserable).

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Headache disorders have historically been neglected and under-researched

Confusion between the variety of headaches—from mild discomfort to debilitating pain—and gender bias—migraines primarily affect women—have led to widespread misunderstandings of the medical issue. Medical students in the US may get as little as 30 minutes of instruction on the three major types: migraines, cluster headaches, and tension-type headaches.

Thousands of donated human kidneys are thrown away annually

Ten donated kidneys are thrown away daily even though thousands of people are awaiting a kidney transplant. Listen to a kidney doctor and a 2012 economics Nobel laureate discuss why this happens and how the organ transplantation system may be improved. Transplant centers are penalized for low transplant survival rates, they note, and that contributes to why hospitals may decide certain organs are just too risky to use.

Explore the gap in what Americans die from versus news coverage on death causes

Top killers like heart disease, stroke, and liver disease, though they represent a significant burden nationally, are not often extensively covered in the media.

There is no cure for the general condition of arthritis

While there are innumerable conditions ultimately leading to the joint pain we collectively term "arthritis," one common pathway is progressive inflammation and joint damage many years after an injury.

The most challenging marathons in the world

Even on a flat course, the event is a taxing ordeal. Now imagine those 26.2 miles climbing some of the world’s highest mountains (via the Tenzing Hillary Everest Marathon or the Kilimanjaro Trail Marathon), across the Great Wall of China, or trekking up the Inca Trail. These races won’t earn you a PR, but they will make for good stories.

Which organs can you live without?

While there are some organs (such as the heart) that people simply can’t live without, there are other organs that can be removed without a huge impact. Patients who have their appendix removed, for example, experience no changes to their daily...

How does cancer actually kill someone?

While the emotional and physical tolls of cancer are often clear, the innerworkings of how cancer kills can be confusing — and terrifying to discuss. Here, oncologists explain how cancer can progress.

Endurance art strains and exhausts the body

Artists like Marina Abramović are known for testing the limits of human endurance. Endurance art can involve carrying heavy objects or posing uncomfortably for long durations. (This resource contains some artistic depictions of violence.)

Autoimmune disorders are one of the top 10 killers of young and middle-aged women

Studies in the US and the UK, though conducted decades ago, have underscored that autoimmune diseases, when grouped together, are a top killer of women.

Extreme heat puts people at risk of developing kidney stones

It's essential to remain hydrated in summer weather to keep your body healthy, but one reason is to help dilute minerals that naturally build up if they aren't excreted in our water-fueled urine. Doctors recommend people generally drink 64 ounces of water a day and also eat foods with salt to help ward off dehydration.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

Ludwig van Beethoven suffered from tinnitus

Historical figures that reportedly had the condition include Charles Darwin and Beethoven. Both men wrote letters about the frustrations and pain they experienced from the condition. (Some users may experience a paywall.)

Misophonia is a neurological disorder where sounds trigger strong emotions

The phenomenon is characterized by decreased tolerance to specific sounds, such as heavy breathing, pen clicking, and water dripping, which trigger a fight-or-flight response. The resulting emotions, which can range from irritation and disgust to anxiety and fear, can be overwhelming and uncontrollable.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

Geneva, Switzerland, has some of the highest grocery prices worldwide

Other cities that made the top 20 on the list of the global cities with the highest grocery prices around the world include Boston, Hong Kong, and Toronto, at least as of 2025.

See 16 art pieces that were inspired by or evoke elements of top phobias

CBC News informally polled readers about their fears and then found works of art either inspired by or nodding to those topics.

Touch deprivation can heighten anxiety and depression

Pacinian Corpuscles are pressure receptors just under the skin that send signals to the vagus nerve in the brain—that's the cranial nerve which regulates involuntary actions like breathing, heart rate, and the general "fight or flight" response. Activating those receptors can slow the heart, decrease blood pressure, and lead to the release of oxytocin and cortisol. The absence of touch, conversely, can promote negative feelings.

Ranking the 10 hottest places on Earth

Death Valley in California often gets the press for the hottest recorded air temperature in the world. What about the runners-up? This list compiles the rest of the Earth's hottest spots, from Jeddah in Saudi Arabia to Kebili in Tunisia.

A framework for the various potential causes of insomnia

Insomnia typically occurs in people dealing with life stressors and physical or mental health conditions, though the exact cause continues to elude researchers. Generally, the factors can be broken down into external (such as stress, medication, etc.) or internal (neurological) factors.

View the most expensive materials on Earth, led by those forged in particle accelerators

Californium-252—valued at $27.8M per gram, as of 2025—is far rarer and more valuable than gold, silver, or diamonds due to production and transportation costs. The most expensive substance ever found or created is antimatter, costing approximately $62.5T per gram.

The word allergy is partly derived from the Greek word 'allos' for 'other'

For people with allergies, their immune systems recognize substances as a harmful "other"—cuing an inflammatory response. This podcast explores allergy details and related topics, including how scientists are interested in if the same allergic response mechanisms could underpin other health issues, including severe, painful symptoms around the time of menstrual cycles. Since estrogen acts on white blood cells called mast cells, which leads to the release of histamines—similar to what happens during allergic responses—an understudied question is whether the same process is fueling some of the uncomfortable symptoms around menstruation. An allergist guest notes this raises questions about if antihistamine medications like Pepsid might alleviate them, something that hasn't yet been explored in clinical trials.

See the global blindness burden by cause and continent

These charts show the estimated number of people worldwide with blindness due to cataract, glaucoma, refractive disorders, age-related macular degeneration, malaria, river blindness, trachoma, and other causes.

There's no definitive test for inflammation, or a baseline for what's considered normal

Existing tests can pick up proteins that indicate an immune response—in particular C-reactive protein, which the liver produces when the body's stressed—but that won't tell you why there's inflammation nor if it's chronic or acute inflammation. (Some users may experience a paywall.)

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Serbian donkey cheese is the most expensive in the world

Only one farm in the world produces pule, a cheese made from rare Balkan donkey milk that can cost up to $600 per pound. Pule is special for a number of reasons, including the unusual ingredients and the amount of labor required to produce it. Everything, including milking the donkeys, must be done by hand.

Wichita is the worst US city to live in if you suffer from seasonal allergies

More than 100 million people in the United States suffer from allergies each year. But Wichita, Kansas, tops the charts year after year as the worst city in America for those suffering from seasonal allergies. Longer and more intense pollen allergy seasons, however, are increasing the burden of living with seasonal allergies in numerous locations across the country.

What is a migraine attack like?

Are you one of the lucky people who've never experienced a migraine? Take the neurological condition for a whirl in this virtual experience sponsored by Excedrin, a pain relief medication brand. This 360º video is less than two minutes long and shows a snippet of an oncoming migraine suffered by a pastry chef.

Drug-resistant staph infection is one of the deadliest superbugs

Methicillin-resistant Staphylococcus aureus (MRSA)—the superbug version of staph infection—is responsible for more deaths than any other superbug, killing more than 120,000 people globally each year. The bug is leading cause of hospital infections, and is harmless on the skin but causes severe symptoms once inside the body.

About half of physicians report feeling burned out

Burnout is often considered a disorder of caregivers, with teachers, doctors, nurses, and social workers reporting high levels of burnout. Among K-12 education professionals, 44% reported experiencing burnout in 2022. Reported rates from emergency care workers is about 60%, the highest in the field.

Several birthstones play key roles across modern technologies

Diamonds are used in drills and quantum computing, while peridot and zircon help in steelmaking and carbon capture. Rubies, sapphires, and alexandrite enable several varieties of lasers found in medicine and advanced optics. Garnets are found in water filtration systems and radiation detectors. Sapphires are used as substrates in semiconductors.

Ranking life's biggest decisions

Psychological research presents some unsurprising wisdom about how to make big decisions without regret: focus on people, don’t miss opportunities, and stay true to yourself.

Why Friday surgeries are (likely) riskier

Scheduling surgery on a Friday may lead to more complications—up to 5% more often—compared to surgeries performed after the weekend. The research was conducted by a team from the United States and Canada and analyzed data from over 450,000 patients who underwent common surgeries in Ontario between 2007 and 2019. Check out their findings here.

A comprehensive review of BPC-157 studies identified no human safety data

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).