Grief rewires the human brain

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Extreme grief elevates cardiovascular risk and lowers immune system function

A 2014 analysis of cardiovascular risk and bereavement after a lost partner found that grief elevates the risk of stroke and heart attack for the 30 days following death of a partner and the risk then attenuates after that.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

Emotional relationships with God affect grief

A study published in 2020 examined how internal, emotional relationships with God—rather than external characteristics of one's religiosity like weekly workshop attendance or attire—affected grief and adjustment among bereaved parents.

Love and heartbreak trigger powerful, neurochemical-driven changes in the body

The feeling of falling in love floods the brain with dopamine, oxytocin and serotonin, which collectively dull pain and boost immunity. However, the loss of these chemicals during a break-up produces withdrawal-like symptoms and heart issues, such as high blood pressure.

A pregnant woman's brain sheds gray matter, perhaps explaining 'baby brain'

The brain areas involved in processing information and emotions decrease by an average of almost 5% during pregnancy. Researchers discovered in a 2025 study that this mostly temporary change—the brain hadn't fully returned to its normal size six months after pregnancy—seems to be associated with self-reported improved bonding and less hostility toward the child postpartum.

The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

The findings, published in 2025, traced three amputees' brain-body maps and how they respond to body part movements—both before and after scheduled arm amputations. The unexpected neural stability suggests that the unchanged pathways for the missing limbs may explain why people continue to feel them so acutely.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Grief is defined as the anguish and physiological distress experienced after significant loss

It usually occurs following the death of a loved one, and symptoms may include confusion, apprehension about the future, separation anxiety, and ruminating on the past.

Brain activity goes into overdrive around the point of death

Recent studies suggest increased electrical activity in the brain during and after clinical death could be responsible for near-death experiences. Both high-frequency gamma waves (linked to perception and attention) and low-frequency beta waves (related to focus and concentration) increased and became more synchronized across multiple brain regions, potentially resulting in a near-death state of heightened consciousness.

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

Researchers use the brain's ability to edit memories to explore memory deletion

Scientists have successfully implanted false memories in mice after studying how the editing process works in the brain. Beyond potentially deleting memories in those with PTSD, upcoming research may allow clinicians to forecast the onset of neurodegenerative diseases.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Consistency and emotional engagement can improve the formation of memories

While sleep lets the brain re-trigger neurons associated with our experiences to cement them in long-term memory, repeating actions, like storing one's keys in the same location, can mimic these benefits. Emotionally charged memories are often ruminated upon, improving their future recall.

How to build curiosity

Change and uncertainty induce stress, but reframing the unknown into an opportunity for discovery has tangible benefits. Approaching change with curiosity enhances activity in the hippocampus and promotes neuroplasticity, promoting learning and serving as a barrier against anxiety. A neuroscientist explains how embracing the unknown, trying small experiments, and other techniques build curiosity.

The limbic system drives emotion, memory, and survival instincts in the brain.

This interconnected group of brain structures—including the amygdala, hippocampus, thalamus, and hypothalamus—processes emotional responses, regulates bodily functions, and plays a key role in memory and learning.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

Listen to how the gut microbiome influences your emotions

The gut-microbiome connection may involve the enteric nervous system, a collection of hundreds of millions of neurons throughout the gut that transmit signals up the vagus nerve to the brain.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

The evolution of the human brain

The human brain, in all its staggering complexity, is the product of millions of years of evolution. Read on to find out about brain size and intelligence, language and brain development, and more.

How grudges mostly hurt ourselves

Grudges feel like revenge against those who have done us some wrong and are very common. In this "Hidden Brain" podcast, psychologists explain how grudges end up only hurting us rather than those we hold them against. By using historical examples, the researchers show the counterintuitive danger of grudges and how people can learn how to avoid them.

The emotional regression that happens when we visit home

Despite how mature we might like to think we are, returning home for the holidays often results in reverting to our moodier, angstier childhood selves. This story in the conversation dives into the root of this phenomenon, which can largely be explained by attachment theory. Read along to understand how your past experiences and attachment style can influence your current behaviors and for advice on how to cope with regression.

Heatstroke can reprogram your DNA, putting survivors at risk of future health problems

Severe illness from extreme heat exposure can alter DNA through epigenetics—turning genes "on" or "off" to shape disease risk. These changes can place an organism at greater risk of future health complications—unlike the epigenetic changes produced by moderate, repeated heat exposures.

How frontotemporal dementia changes your personality

Significant changes in personality later in life are often attributed to psychological factors. But Dr. Bruce Miller, long-time researcher of FTD, argues this shift is most often attributable to changes in the brain.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.

View the ten deadliest tornadoes in US history.