How alcohol rewires your brain

'1440 Explores,' Episode 2: Why We Drink and What It Does to US

Alcohol is the world's most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol's journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

Addictive drugs can cause dopamine levels to become ten times higher than normal

Now recognized as a physiological brain disease, addiction rewires the brain's reward system to make drugs feel necessary and weaken self-control by dulling the relative effects of natural rewards like food and social connection.

Move over gene editing, scientists can edit your epigenome

Instead of deleting genes, epigenetic editing modulates their activity. A new paper tests if it’s able to undo a genetic effect of early alcohol exposure.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Delirium tremens is the most severe form of alcohol withdrawal

Due to the impact of alcohol on the central nervous system, withdrawal from the drug can cause severe effects. Roughly 1% to 1.5% of heavy drinkers will experience delirium tremens, which includes tremors, seizures, hallucinations, and more. Onset typically occurs 48-72 hours after the last drink.

How fermentation works

Alcoholic fermentation is the process where yeast transforms grape sugars into ethanol, creating wine. Microscopic fungi (commonly known as yeast) metabolize sugars, producing alcohol and carbon dioxide. Fermentation's speed and temperature impact wine's flavor and style: cooler temps suit fruity whites, while warmer ones enhance red's tannins. Fermentation stops when sugars are depleted or by temperature extremes, and sometimes yeast removal yields sweeter wines. Get a quick breakdown of the process with this easy explainer.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

The brain will attempt to rest itself in periods of chronic sleep deprivation

Skimping on sleep lengthens reaction times and blunts decision-making skills. At a certain point, the brain will try to sneak sleep where it can, shifting sections offline even as you remain awake. Going without sleep raises blood pressure, undermines the immune system, and increases one's risk of dementia.

Anesthetics slow brain activity by promoting inhibitory neurotransmitters

Drugs like propofol and isoflurane increase activity at the GABA receptor, which opens chloride channels. These ions enter neurons and hyperpolarize them, making them less likely to fire. Dexmedetomidine instead blocks norepinephrine receptors in the brainstem to sedate patients.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The federal government allowed toxic chemicals into alcohol during Prohibition

Industrial alcohol was still legal during Prohibition, and was often used by bootleggers. In an attempt to disrupt the black market, the government required toxic additives to be included in industrial alcohol, leading to more than one death.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

Naltrexone blocks the reward effects of alcohol and opioids

Naltrexone is used to treat alcohol and opioid dependence, blocking opioid receptors in the brain, reducing cravings, and preventing the euphoric effects of alcohol or opioids. It is nonaddictive and works best as part of a comprehensive treatment plan, including counseling or therapy, to support long-term recovery.

Cocktails now increasingly feature strange ingredients like bacon fat

Cocktail mixology has evolved in recent decades, shifting from a revival and reimagining of old favorites to pure experimentation. Where drinks were at one time anchored by a long-established favorite, now drink menus can feel incomprehensible to the average drinker, and little to indicate what the ultimate flavor profile of the libation will be.

1440: Everything you need to know about Alzheimer's

What is Alzheimer's, and is it different from dementia? In short, yes—Alzheimer's is a specific brain disease that falls under the umbrella of dementia. However it is the most prevalent form of the condition, accounting for 60 to 80% of reported dementia cases.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

Alcoholics Anonymous leads to increased abstinence compared with other treatments

That's according to a 2020 meta-review of 27 studies. This large analysis found that Alcoholics Anonymous had between 22 and 37 percent abstinence numbers as compared to other treatments that had figures of about 15 to 25 percent. AA was founded in 1935, in Ohio, and depends on peer connections and consistent meeting availability. (Some users may experience a paywall.)

Xylitol, a sugar alcohol, is sometimes added to foods at 1,000 times the level seen naturally in foods

This article covers the latest research in sugar alcohols and heart health. Some work indicates that after consuming sugar alcohols erythritol or xylitol people are at an elevated risk of developing blood clots, which can cause heart attacks and strokes. Both substances occur in low levels naturally in fruits and vegetables and are also produced by the human body, but as sweeteners in foods they are present at exponentially higher levels.

Happy hour is banned in Ireland

For a country famous for drinking a lot of alcohol, it might seem surprising that happy hours are banned in Ireland. But that reputation is exactly why the country banned happy hours in the first place—a 2010 report found that alcohol use in Ireland had doubled between the 1970s and the early 2000s. Read this article to learn more.

Coffee gives you energy, but it ultimately makes you more tired

The caffeine in coffee delays your brain's fatigue signals. Caffeine blocks adenosine, a compound that builds up as you burn energy and signals rest. Once caffeine wears off, adenosine floods back, leaving you even more tired.

Gen Z is drinking less alcohol than older generations

In the years 2001 through 2003, 72% of adults under age 35 said they drank. But by the time the years 2021 through 2023 rolled around, only 62% of under-35 adults could say the same, according to one recent study.

What a railroad spike through the head taught science about the brain

In 1848, a railroad worker survived an accident that drove a 13-pound iron bar through his head. The injury changed his personality, and our understanding of the brain.

Horses can—and sometimes should—drink beer

Despite its reputation, beer is a good source of nutrition. In fact, it's a fairly common practice for horse owners to give beer to their horses. Beer is rich in skin-healing B vitamins, gut-stabilizing yeast, and hydration-encouraging barley. Plus, horse livers come prepared with special enzymes that break down alcohol, making inebriation nearly impossible.

How your subconscious influences your decisions

How much of your desires and daily choices are truly yours? One of the most effective ways to influence someone's subconscious is when they're asleep. To study this possibility, researchers trained participants to be able to dream lucidly, a phenomenon that occurs when a dreamer knows they're dreaming.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Fireworks make a loud booming sound after exploding due to air expanding faster than the speed of sound.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

The boiling temperature of water decreases with increasing elevation because the molecules need less energy to overcome the lower atmospheric pressure associated with thinner air.

Exploring the Larry Bird punch that almost changed March Madness

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls