Naltrexone blocks the reward effects of alcohol and opioids

Narcan is an opioid antagonist that can rapidly reverse overdoses

Naloxone, also known by the brand name Narcan, is an opioid-overdose reversal medication that typically begins working within a few minutes. An opioid antagonist, the treatment attaches to opioid receptors without activating them, forcing opioid molecules out of their respective receptors and allowing users' breathing rates to normalize.

Methadone binds to the same receptors as heroin and other opioids

Methadone is a long-acting opioid agonist that works by binding to the same brain receptors as other opioids (like heroin or morphine), but without producing intense euphoria. It reduces withdrawal symptoms and cravings, helping people stabilize and avoid illicit opioid use.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

How the body produces its own opioids

Opioids act on the body's own opioid receptor system. The endogenous opioid system comprises four molecule receptor types found throughout the body. When activated, these receptor types trigger the release of dopamine and suppression of noradrenaline, neurotransmitters, respectively, associated with reward and alertness. This opioid system helps regulate emotions, and its disruption is linked to neuropsychiatric conditions, including depression, PTSD, and Alzheimer's disease.

Addiction is defined as chronic compulsive drug use despite adverse consequences

This resource from the National Institute on Drug Abuse provides a comprehensive look at addiction as a complex brain disorder. It explores why people initially take addictive substances and how continued use alters the brain’s reward system.

Alcoholics Anonymous leads to increased abstinence compared with other treatments

That's according to a 2020 meta-review of 27 studies. This large analysis found that Alcoholics Anonymous had between 22 and 37 percent abstinence numbers as compared to other treatments that had figures of about 15 to 25 percent. AA was founded in 1935, in Ohio, and depends on peer connections and consistent meeting availability. (Some users may experience a paywall.)

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

GLP-1 drugs are under investigation for treating Alzheimer's, Parkinson's, and drug addiction

Researchers are investigating GLP-1 applications for a variety of chronic conditions. One area of interest stems from how study participants using GLP-1 for diabetes and obesity reported describing less longing for wine and cigarettes while taking the medication—intriguing researchers about using the drugs for addiction applications. The drug, they theorize, could bind to receptors that mediate desire. (Some users may experience a paywall.)

Bupropion is the only antidepressant approved for the preventive treatment of SAD

Clinical trials showed a 44% reduction in risk for recurrence of SAD for those who took the drug compared to a placebo group. Bupropion is a norepinephrine–dopamine reuptake inhibitor, which increases dopamine (other common antidepressants, known as selective serotonin reuptake inhibitors, sometimes can suppress dopamine, but not always).

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

Social support plays a critical role in recovery from addiction

This engaging TEDx talk from addiction researcher Jacki Hillios explores addiction recovery through a transformative lens and Phoenix Multisport—an innovative program helping people rebuild their lives through active lifestyles. By living out its core message that people are not defined by their disease, the program demonstrates the power of social support in recovery.

The non-alcoholic wine market

A no-nonsense, stats-based exploration of the relatively new market for nonalcoholic wine. Driven by people looking to consume less or no alcohol at all, production of nonalcoholic wine has increased dramatically over the last few years. This report details the basics of nonalcoholic winemaking, as well as the current state of the market and what to expect in the future.

Opioid epidemic 101: lawsuits and settlements

State and local governments trying to address the opioid epidemic have sued organizations they believe started and supported the crisis. Companies that made, distributed, or contributed to sales of the highly addictive painkillers are expected to pay more than $50B in settlements. These settlements specifically state that at least 85% of settlement funds must be spent on addressing the epidemic, though where exactly the money is going is unclear.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

Mifepristone, approved in 2000, is used to end early pregnancies

The drug works by blocking progesterone, a hormone that is needed to support pregnancy. Mifepristone is typically used in combination with a second drug, misoprostol, because this regimen often causes less cramping and bleeding than just using misoprostol alone.

Immunosuppressants enable organ transplants, but come with severe side effects

This drug cocktail helps to lower your body's natural response to attack a transplanted organ. Such medications usually need to be taken for a lifetime after receiving an organ and can come with serious side effects including high blood pressure, diabetes, increased risk of some cancers, and high cholesterol, among others.

The negative effects of cannabis use

After decades of criminalization, cannabis is a legalized drug in an increasing number of countries around the world. This allows for accurate, robust research on the drug's effects on humans . While weed isn't as harmful as alcohol, regular usage has its negative effects. As strains of the drug become stronger, so does its consequences. Watch this video for a lucid look at the effects of cannabis on its users.

A first-of-its-kind clinical trial taps livers from gene-edited pigs to clean blood

The experimental dialysis-like treatment from United Therapeutics, eGenesis, and OrganOx, is designed to help people with liver failure. The therapy, which involves attaching the modified pig liver externally, filters a patient’s blood so their own livers can temporarily rest and perhaps heal.

The benefits of extreme pain rituals, explained

We naturally avoid pain and see it as a negative experience. But many traditional cultures incorporate extremely painful rituals into their religious ceremonies, claiming they, in fact, provide ample benefits. Researchers were able to observe boosts in happiness and a sense of belonging in a tribe of Mauritians after they undertook a rigorously painful religious ritual. Read about the study here.

Smell retraining can help people with anosmia learn to smell again

Olfactory training, which involves repeatedly smelling a selection of strong odors, teaches your brain to familiarize itself with experiencing smells over a lengthy period, typically multiple months. This can be useful for patients who lose their sense of smell for myriad reasons.

Researchers are investigating if nanoparticle treatments could combat allergies

In rodent work, Northwestern University’s Evan Scott (now at the University of Virginia) and his colleagues have been trying to attack allergies with specially designed nanoparticles—miniscule lab-made objects that can penetrate cells. They stud the nanoparticles with a tiny bit of the allergen specific to the allergy (i.e. cashew protein for cashew allergy) and antibodies that shut down allergic response processes.

Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

This common symptom—a flat affect—results in previously enjoyable hobbies no longer bringing pleasure. People with anhedonia may also avoid social situations because they anticipate they'll bring no joy, not because of anxiety or fear.

Receptors on the cell surface are key to whether a virus is successful

Viral receptors are key regulators of host range, tissue tropism, and viral pathogenesis—basically, the door locks on cells allowing viruses to invade, if they have the right key. How this process works at the microscopic level determines whether a virus is able to trigger a widespread illness in the host.

The acronym NFT stands for non-fungible token

NFTs have developed as a secure way to use cryptocurrencies and the blockchain to create unique digital art, allowing the owner to prove ownership of a specific digital item.

Notch music therapy may filter out some tinnitus frequencies

Researchers in Germany have developed a smartphone app-based therapy for individuals with tinnitus associated with hearing loss. Some people with tinnitus can use this Notch app with their hearing aids to at least partially block sound frequencies matching their tinnitus pitch—turning down the volume of their tinnitus.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

See the evolution of Ebola vaccine and treatment development.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Artificial coral reefs have been 3D printed from nontoxic, biodegradable terracotta clay, which coral polyps have used as a foundation for rebuilding marine ecosystems.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.