Addiction is defined as chronic compulsive drug use despite adverse consequences

Addiction develops when the pleasure circuits in the brain get overwhelmed

Normal pleasure circuits become overwhelmed by addictive substances, triggering dopamine floods many times stronger than those induced by everyday reward experiences. The understanding of addiction as a brain disease has led to treatments pairing medication and counseling.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

The science of addiction treatment

A helpful resource from the National Institute on Drug Abuse (part of the NIH). This article examines addiction treatment and recovery through the science behind several accepted methods. The guide draws helpful comparisons with other chronic disease treatments. In particular, it discusses the overlap between medications and therapeutic treatments, and the understanding that relapse doesn’t indicate treatment failure—only a need for continued or modified care.

Addictive drugs can cause dopamine levels to become ten times higher than normal

Now recognized as a physiological brain disease, addiction rewires the brain's reward system to make drugs feel necessary and weaken self-control by dulling the relative effects of natural rewards like food and social connection.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

The National Institute on Drug Abuse's resource library

The National Institute on Drug Abuse website is an in-depth and highly prolific resource on addiction science. Explore the vast scope of this website to access comprehensive guides, data visualizations, and educational materials on all facets of addiction and its treatment.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

Drug tolerance and withdrawals are consequences of overloading dopamine circuits

Addictive substances or behaviors will typically flood our brains with more dopamine than usual. In response to the overstimulation, our brains will decrease the number of available dopamine receptors. This results in the need for more stimulus for the same response (tolerance) and a rise in negative feelings when the stimulus is absent (withdrawal).

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

Can the gut microbiome drive addiction?

New research suggests an imbalance of gut microorganisms may influence the likelihood of addiction and addictive behaviors by increasing the severity of withdrawal symptoms, triggering brain inflammation in regions of impulse control, and more.

Coffee is, indeed, addictive

Caffeine enters the brain through the bloodstream, where it blocks receptors that cause us to feel tired and enables stimulants like dopamine to increase alertness and focus. Over time, the brain begins to expect this level of stimulation, and caffeine addiction can develop. Caffeine withdrawal causes headaches, irritability, and fatigue.

'The opposite of addiction isn't sobriety—it's human connection'

This thought-provoking TED talk from journalist Johann Hari challenges conventional wisdom about addiction, with a special focus on his global research investigating its root causes. Through personal stories and scientific evidence, Hari debunks some of the most common myths around addiction.

Is workaholism real?

Though work addiction is not officially recognized as a medical condition, it mirrors many patterns of other behavioral disorders. This exploration from BBC News examines the issue through Workaholics Anonymous, with a special focus on firsthand accounts from support group members.

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

Frictionless online gambling platforms accelerate compulsive behavior

As of late 2025, as much as 95% of bets are placed online, where "always on" betting and a variety of formats, such as prop bets and parlays, encourage users to keep participating. Experts warn that the normalization of gambling through advertisements also reduces the perceived danger of addictive gambling.

Drugs 101: An interactive guide

What's the difference between opioids and psychedelics? This guide details specific drugs and their various associated effects. Drugs in this wheel fall into seven categories: stimulants, depressants, empathogens, psychedelics, dissociatives, cannabinoids, and opioids.

Obsessive compulsive disorder is a mental health disorder, not a personality quirk

In popular culture OCD has been incorrectly overused to describe neatness or perfectionistic behaviors, but the disorder involves intrusive thoughts and compulsive behaviors that take over a person's actions.

'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

Many people with ADHD are prescribed stimulant medication to assist with symptoms ranging from time blindness to executive dysfunction. This hour-long podcast episode by Search Engine explores the host's experience with ADHD medication and the history of amphetamine and methylphenidate use in the US.

It seems like we shouldn’t have to say this: Cheese is not like crack

While news reports may claim cheese is addictive, the facts behind the research show cheese and crack have little in common. It appears that highly processed foods with high levels of sugars and fat, rather than cheese specifically, are most closely associated with addictive-like behaviors. In fact, cheese ranked lower than foods like pizza, chocolate, and fries in terms of its addictiveness.

The story of the Sackler empire behind highly addictive OxyContin

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

Narcan is an opioid antagonist that can rapidly reverse overdoses

Naloxone, also known by the brand name Narcan, is an opioid-overdose reversal medication that typically begins working within a few minutes. An opioid antagonist, the treatment attaches to opioid receptors without activating them, forcing opioid molecules out of their respective receptors and allowing users' breathing rates to normalize.

Clinical insomnia is defined as trouble sleeping for three nights per week for at least one month

The term "insomnia" is often used in popular culture to refer to general difficulty sleeping or staying asleep. In the US, insomnia transitions to a clinical disorder when symptoms—dissatisfying, nonrestful, and life-disrupting sleep—occur at least three nights per week for at least one month and cause "clinically significant" distress in important areas of life.

Diabetes is a chronic disease linked to insulin production and high blood sugar

Diabetes is a chronic, progressive disease caused by a lack of, or problems processing, the hormone insulin, leading to persistently high blood sugar. Around 90 to 95% of cases are Type 2 (chronic and caused by factors like diet and environment). The remainder are Type 1 diabetes (an autoimmune disorder).

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

Common genetic disorders

As research continues, it's clear that disease and genetics go hand in hand. Here's a selection of 50 National Human Genome Research Institute (NHGRI) articles providing basic information on genetic, orphan, and rare diseases caused by mutations in DNA sequences, whether inherited from parents or brought about by outside factors.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

A century of Billboard issues documenting the evolution of popular music.

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Despite being favored by 87% of Americans, Congress does not have term limits.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.