'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

SAD uniquely affects people with attention-deficit hyperactivity disorder

Those with ADHD—chronic issues with attention and executive function—are primed for SAD. Many are disproportionately evening chronotypes (more awake in the evening), have a delayed sleep phase, and have low sensitivity to light in the morning. This podcast explores the overlap between these two groups.

ADHD impairs working memory and limits the ability to form long-term memories

While ADHD is most often recognized for producing struggles with attention and organization, these executive functions are critical for capturing the data that creates memories in the brain. Breaking data into pieces, or chunking, helps address these struggles.

What’s with the teen brain, anyway

In this video NIDA explores the intriguing similarities between the processes of brain development and computer programming. This analogy helps us understand why toxic environmental factors like drugs, bullying, or lack of sleep strongly affect a teenager’s life The information provided by this video can empower your children or students with information they need make better decisions.

Why are kids increasingly diagnosed with myopia?

According to the World Health Organization, 40% of the world will have myopia—nearsightedness—by 2030. This NPR podcast episode details why people are being diagnosed with myopia at increasingly younger ages. Early onset myopia can lead to...

The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone, an opioid with distinct effects from heroin, revolutionized heroin addiction in the 1960s. Marie Nyswander was a psychoanalyst who helped discover the treatment process which is still in use today. Here's a podcast episode examining her life and role in the field of addiction treatment.

'1440 Explores,' Episode 2: Why We Drink and What It Does to US

Alcohol is the world's most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol's journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The gray area that makes PEDs seem like leveling up to hardcore athletes

Doping in sports is broadly condemned as unsafe and unfair. Significant controversies in major sports, including baseball and cycling, have been prompted by the widespread use of performance-enhancing drugs, which are described as clear-cut dangers and abuses of the rules. But to many competitors, the line between a PED and the next smart technique to adopt is unclear. This podcast episode explores that gray reality.

1 in 10 US adults are taking medication for depression

A US government report indicates that about 10% of US adults took prescription medication for this disorder in 2023. Women, at 15.3%, were more than twice as likely to take one of these medications than the 7.4% of men.

Can we speed up our metabolisms?

Listen to this 31-minute podcast to better understand what science knows and doesn't know about metabolism, as well as the only thing that seems capable of changing it. Scientists understand that the difference between a so-called “fast” and “slow” metabolism does not affect one’s ability to lose weight.

Even brief physical activity can trigger the release of neurotransmitters that provide mental health boosts

A couple of minutes of light walking or stretching can increase feelings of energy and reduce fatigue, not just through the release of endorphins. Exercise can also provide self-regulation and improve task engagement and focus in those with certain mental health disorders, like ADHD.

What exactly is dopamine?

Dopamine is a neurotransmitter—a chemical released by neurons that enables neural communication—that makes people want things with an "almost animalistic desire," compelling them to snack or check phone notifications. Often misrepresented as a "pleasure" chemical, dopamine is involved in motivation, learning, attention, habit formation, and more. Trends like dopamine fasting overinflate its role in mental health and often use it as part of "straw man" biohacking claims.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

Mapping where the drug captagon is seized worldwide

In the 1960s, Captagon was patented in Germany as a stimulant similar to amphetamines. It was prescribed for a time to address narcolepsy, ADHD, and other conditions. As its addictiveness and psychosis-inducing quality became more apparent, the drug has been banned in many countries. A robust illicit manufacturing of the drug endures in the Middle East, especially in Syria and Lebanon. Track locations where the drug has been seized on this updated map.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure

This podcast takes on the thorny mismatch between recent research linking herbicide exposure to Parkinson's disease and federal and state regulators' conclusions that there is insufficient evidence to establish causality. Though the main company that produces the herbicide Paraquat has recently stopped making it, dozens of others continue to do so, prompting concerns from some Parkinson's patients and scientists about disease risk and the pace of scientific answers. 

Coffee is, indeed, addictive

Caffeine enters the brain through the bloodstream, where it blocks receptors that cause us to feel tired and enables stimulants like dopamine to increase alertness and focus. Over time, the brain begins to expect this level of stimulation, and caffeine addiction can develop. Caffeine withdrawal causes headaches, irritability, and fatigue.

Explore this deep dive into how SSRIs work

This 101-style explainer on selective serotonin reuptake inhibitors explains how they work in the brain—complete with classroom-style whiteboard drawings. It covers common SSRIs, why someone might try this medication, and a deeper discussion about potential side effects.

What (and why) is ASMR?

ASMR podcasts and videos are appearing all over social media, so what exactly is it, and what does it do? This immersive article explains the phenomena of ASMR, which stands for autonomous sensory meridian response. ASMR is when certain sounds or...

This decongestant doesn't work, so why is it still for sale?

Over-the-counter decongestants powered by phenylephrine won't help those with stuffy sinuses find relief, according to current evidence. This 10-minute video explores why these useless medications are still for sale in the US. The decongestant...

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Inside the rise of focus music

Any casual YouTube or Spotify user has likely stumbled upon a playlist called "lo-fi beats to study and relax to" while searching for new music. Those "lo-fi beats" actually represent a growing genre of music called "focus music." Spotify, for instance. saw a 50% increase in listening time for focus playlists in its 2023 Wrapped report. This article explains why productivity tunes are on an upswing right now. Read it here.

Dietary supplements are regulated like foods

This hour-long 2016 documentary from Frontline, the Canadian Broadcasting Corporation, and The New York Times examined the safety of dietary supplements. It noted that this then-$30B industry (it's at least doubled since then) suffers from irregularities and impurities. It warned that many Americans are unaware of the lack of regulatory oversight over these products.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The word allergy is partly derived from the Greek word 'allos' for 'other'

For people with allergies, their immune systems recognize substances as a harmful "other"—cuing an inflammatory response. This podcast explores allergy details and related topics, including how scientists are interested in if the same allergic response mechanisms could underpin other health issues, including severe, painful symptoms around the time of menstrual cycles. Since estrogen acts on white blood cells called mast cells, which leads to the release of histamines—similar to what happens during allergic responses—an understudied question is whether the same process is fueling some of the uncomfortable symptoms around menstruation. An allergist guest notes this raises questions about if antihistamine medications like Pepsid might alleviate them, something that hasn't yet been explored in clinical trials.

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

A sleep expert discusses the broad benefits of quality rest

In this three-part series, renowned sleep expert Matthew Walker and doctor Peter Attia explore the role of sleep in memory consolidation and mental health, and the detrimental effects of chronic lack of sleep. The latter has been linked to increased risk of dementia, hypertension, and more.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.