The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone binds to the same receptors as heroin and other opioids

Methadone is a long-acting opioid agonist that works by binding to the same brain receptors as other opioids (like heroin or morphine), but without producing intense euphoria. It reduces withdrawal symptoms and cravings, helping people stabilize and avoid illicit opioid use.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

Learn about the US opioid crisis in this free course

Where did the US opioid crisis come from, and how did it spread? Learn this and more in this free, online Harvard University course. Learn about the disease model of addiction treatment and management, and get up-to-date with public health and law enforcement's current harm reduction practices. This free resource gives users a greater understanding of opioid addiction and the epidemic still haunting the US.

​Why heroin became associated with the grunge world

The drug was popular with several Seattle acts in the early 1990s, with artists like Hole's Courtney Love even publicizing her use in a magazine profile. A 1992 New York Times story on Seattle said the city's principal drugs were "espresso, beer, and heroin."

Why is fentanyl poisoning street drugs?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, is enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose. This 39-minute podcast episode is the first half of a two-part series exploring fentanyl's rise.

'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

Many people with ADHD are prescribed stimulant medication to assist with symptoms ranging from time blindness to executive dysfunction. This hour-long podcast episode by Search Engine explores the host's experience with ADHD medication and the history of amphetamine and methylphenidate use in the US.

Evidence of opium use dates to as early as 5000 BCE

Archaeological evidence shows the use of the poppy plant for its pain-killing properties likely originated in the Mediterranean before making its way to the East and West via trade. It has since inspired two eponymous wars, and highly addictive derivatives of the naturally occurring substance have led to an ongoing overdose crisis.

'The opposite of addiction isn't sobriety—it's human connection'

This thought-provoking TED talk from journalist Johann Hari challenges conventional wisdom about addiction, with a special focus on his global research investigating its root causes. Through personal stories and scientific evidence, Hari debunks some of the most common myths around addiction.

Marie Curie pioneered radioactivity research, for which she won two Nobel Prizes

Marie Curie and her husband isolated polonium and radium despite poor lab conditions and financial hardship. President Harding, on behalf of the women of America, presented her with one gram of radium in 1921 in recognition of her service to science.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

A 49-year-old American died at an ibogaine clinic in Mexico, underscoring its risks

The man had sought out the drug to help him overcome his substance abuse disorder. Though anecdotal reports indicate potential promise, there's been no large-scale clinical trials on ibogaine's safety and efficacy. The plant is derived from a root bark named iboga and has been used for centuries by indigenous communities in Gabon, but first entered scientific consciousness in 1901 after its alkaloid was isolated from Iboga.

Understanding insulin

Scientists Daniel and Kelly talk with researcher Dr. Katrine Whiteson about diabetes, the history of insulin production, and Dr. Lydia Villa-Komaroff—an essential member of the team who discovered that bacteria could be induced to produce insulin. Listen to discover interesting facts about the life-saving medicine and how it works in the human body.

See how antidepressants were discovered

The decadeslong journey to the three major types of antidepressants began with medications designed to treat other maladies. Watch to learn more about how attempts to treat tuberculosis and blood pressure disorders led to new insights about neural chemistry and mood.

Hear from a couple about how they live their lives with MS—and how they met

This short narrative video describes the ups and downs of a woman's experience with progressive MS, and her husband's experience supporting her while navigating his own relapsing-remitting MS.

USA Today asked readers about their grief—and received more than 700 responses

The submissions included one moving story of two women whose sons died by drug overdose. The duo wrote that they found each other in a support group and decided to navigate their respective difficult situations by starting a podcast together called "Two Moms with Two Dead Kids," which focused on what life was like in the years following the deaths of their children.

Understanding how Billie Holiday's traumatic childhood led her to drugs

At 10 years old, the jazz singer was raped and then returned to House of the Good Shepard under protective custody. Her rapist was eventually convicted, but the court still sent her to an all-girls Catholic reform school. Jake Brennan, the host of the Disgraceland podcast, believes those early events led Holiday to the transcendent world of performing, but that it also led her to the escape of drugs.

Tracking the Isdal Woman

In 1970, a burnt body encircled by an odd assortment of items was found in a remote Norwegian valley. For nearly 50 years, the true identity of the woman escaped authorities who found she had traveled the country under many names. This podcast episode is the first in a 12-part series seeking to uncover the woman's identity and what happened in her final moments.

Dylan influenced many of his contemporaries

Dylan’s groundbreaking approach to songwriting didn’t just change his career; it changed the trajectory of American popular music. This podcast from the National Association of Music Merchants’ oral history project features interviews with several Dylan compatriots and fans–including Pete Seeger, Emmylou Harris, and Robbie Robertson–who detail how Dylan changed their careers and how they viewed songwriting.

Hear the story of Truth's life

This podcast traces Truth's life from slavery in New York to her status as an abolitionist icon—covering her daring escape, legal victories, landmark speeches, and lasting impact on racial equality and women's rights.

The Washington Post's Janet Cooke returned her Pulitzer

When Washington Post reporter Janet Cooke published her profile of a 8-year-old heroin addict named Jimmy in 1980, it created an instant uproar. Social workers, police officers, and even the mayor of Washington, DC all jumped into action to try to get the child help, but no one could find him. Within hours of Cooke receiving a Pulitzer for the piece, everything began to unravel as it was revealed that she had fabricated not just Jimmy's story, but her own as well. She eventually returned the award.

Go inside the global effort that led to the Montreal Protocol in this narrative podcast

Nobel laureate Mario Molina and other key voices recount how science and diplomacy converged to develop a plan to close the ozone hole, offering insight into history's most successful environmental treaty.

See this 201-level explanation about mitochondria and mitochondrial replacement therapy

This 2022 academic presentation from Stanford University's Dr. Gregory Enns offers a detailed overview about mitochondrial therapy approaches. Enns, a pediatric geneticist, explains how well-functioning mitochondria support the human body.

The biopic 'Deliver Me From Nowhere' was inspired by a podcast episode

The film’s producers were inspired to pursue the project after hearing an episode of Marc Maron’s “WTF” podcast with Warren Haynes, who wrote the book the film was based on.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands

Saccharin, aspartame, and cyclamate all have origin stories from lab workers tasting something sweet on their hands. A Johns Hopkins University worker in the late 1800s, for example, tasted something sweet on his (unwashed or poorly washed) hands during dinner, prompting him to then taste everything on his lab bench in order to identify that the sweetness was a compound derived from his overheated coal tar—a substance he later named saccharin. (Some users may encounter a paywall.)

Learn about a new schizophrenia healthcare model that's making a difference

Schizophrenia used to be considered a progressive disease that was beyond a patient's ability to manage. This article gives an in-depth look at OnTrackNY, a New York-based program that empowers patients to define the goals of their own treatment for psychotic disorders. At the time of this 2022 article, it consisted of 25 affiliate clinics and hospitals in 14 New York counties, with another seven sites then slated to begin offering services in 2023.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Comedy legend Catherine O'Hara, star of 'Schitt's Creek' and 'Home Alone,' quit 'Saturday Night Live' after just one week to return to her old job.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.