Understanding insulin

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Leonard Thompson was the first human to receive an insulin injection for diabetes

In January 1922, the 14-year-old was the first person to receive an insulin injection to treat diabetes, just months after insulin was isolated in dogs and used to treat their induced diabetes. Thompson had an allergic response to an apparent impurity in the injection, but his second dose, 12 days later, was a success.

An overview of 200 years of diabetes treatment

Diabetes treatment became truly effective after the advent of insulin injections in the early 1900s. Diabetes is becoming increasingly common. Current trends estimate one in three Americans will have diabetes by 2050. This overview explores two centuries of diabetes treatment—starting in 1812—and outline potential challenges to treatment and prevention.

Insulin is a hormone that controls blood sugar by helping absorb it into cells

Blood sugar levels increase after a meal when the body starts turning food into usable fuel—sugars, proteins, and more—which are absorbed into the bloodstream through the intestines. Blood sugar levels rise, releasing insulin, and letting sugar in the blood be absorbed into hungry cells, thereby dropping blood sugar levels.

Type 1 diabetes is an inherent autoimmune disorder inhibiting insulin production

Diabetes causes the body to attack insulin-producing cells in the pancreas, causing a shortage or lack of insulin. This prevents the body from accessing and storing blood sugar—the brain and muscles' primary energy source. It's unclear what causes Type 1 diabetes, an incurable yet manageable chronic condition as of 2024.

Early peptide research focused on isolating the substances from animal tissue

In the first half of the 20th century, peptides including insulin and adrenocorticotropic hormone were isolated from animals to provide life-saving medicines. ACTH was isolated from the pituitary glands of cows and pigs and insulin was isolated from the pancreas of dogs and cows.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

The inner life of a cell

White blood cells are responsible for protecting the human body from infection. This video uses biophysical data from Harvard researchers to accurately demonstrate what goes on inside one white blood cell as it works within the immune system.

Recombinant DNA technology turns microorganisms into protein factories

Genes for molecules such as insulin can be inserted into loops of bacterial DNA called plasmids and reinserted into bacteria. Once placed in fermentation tanks, these bacteria use the gene to produce these molecules, which are then harvested and purified for eventual use.

Debunking myths about weight loss drugs

Business Insider delves into the research on GLP-1 to highlight the good and bad aspects other stories overlook. Few make it clear that GLP-1 drugs simply don’t work for many people. This deep dive raises a number of questions about the future of GLP-1 and how they will be used.

Harvard and MIT researchers are developing life-saving tattoos

Tattoos aren’t just a fashion statement. Scientists are trying to find life-saving applications for them. Harvard and MIT researchers are developing tattoo inks that react to body chemicals, alerting diabetics to blood sugar fluctuations or athletes to dehydration. Someday, patients may observe their body chemistry with tattoos that change colors.

This scientist treated her own cancer

Virologist Beata Halassy treated her own breast cancer by injecting the tumor with lab-grown viruses. Though this self-treatment worked, it has not been approved for widespread use. Read to learn more about her fascinating experience, and how it has led to conversations about safety and ethics.

About two-thirds of humans lose their ability to produce lactase after weaning

Lactase is an enzyme that digests lactose—a sugar in milk and dairy products. While genetics strongly determines lactase persistence, factors like famine, disease exposure, and gut bacteria also influence symptoms and evolution.

Why humans survived and smarter species did not

This interview with Joseph Henrich, a renowned professor of human evolutionary biology, unpacks human history. Henrich shares interesting information about why humans succeeded as a species (the answer isn't IQ), how cultural evolution works, why the human brain is shrinking, and how the Catholic Church played a role in the Industrial Revolution. Listen and watch for a deep dive into human evolution.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

'Cells Making Cells': 'Science Sam' discusses the potential of stem cells

In this episode of the Ologies podcast, host Alie Ward picks the brain of science communicator Samantha Yammine—whose PhD work focused on neural stem cells. The conversation covers everything from the earliest days of stem cell research to what the future of stem cell therapies may look like.

Addressing lifestyle factors, which influence inflammation, can cure some chronic diseases

In this video, a physician claims that he reversed a patient's Type 2 diabetes in six weeks by addressing inflammation drivers such as diet. More broadly, he argues that society needs to better consider and address numerous disease factors that are modulated by inflammation, such as stress, sleep, diet, and movement.

Explore an animated list of nine scientific breakthroughs funded by NASA, the NSF, and the NIH

Among the technologies made possible by the National Science Foundation and the National Institutes of Health were the CAPTCHA digital puzzles to block bots from accessing sites, the set of diabetes and obesity drugs that fall under the umbrella of GLP-1 receptor agonists, and various cordless appliances, including the handheld vacuum cleaner. (Some readers may experience a paywall.)

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone, an opioid with distinct effects from heroin, revolutionized heroin addiction in the 1960s. Marie Nyswander was a psychoanalyst who helped discover the treatment process which is still in use today. Here's a podcast episode examining her life and role in the field of addiction treatment.

Learn about the more than 100 known autoimmune diseases

Explore this resource with summaries and related resources for the dozens of autoimmune diseases defined in the medical literature. Many of these disease write-ups also have interviews with a patient with the disorder—offering a personal take about challenges, advice, and lifestyle effects.

Hookworm infection, though risky, may help fight certain health conditions

Early clinical trial research suggests that the parasites trigger the production of specific proteins that quiet our immune systems. This keeps the parasites from being killed, but it also quiets the inflammatory response that underpins allergies, type 2 diabetes, celiac disease, and other autoimmune conditions. Researchers still caution that infection with too many hookworms can cause serious medical complications and that this is not a standardized or approved medical treatment.

A student researcher working on the Human Genome Project shares their perspective

In a conversation with Ewan Birney, Director of the European Bio-informatics Institute, he discusses what it was like to be a PhD student working on the Human Genome Project in the months before the draft announcement and its impact on him and the field of genetics.

A quick technical overview of insomnia

Insomnia is one of the world's most common sleep disorders. Characterized by difficulties falling and staying asleep, long-term struggles with insomnia can prelude or contribute to health difficulties. Treatments range from sleep hygiene management and relaxation therapy, and medication, including antidepressants and melatonin.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Myokines are molecules that facilitate some of the benefits of exercise

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

See the evolution of Ebola vaccine and treatment development.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.

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