Leonard Thompson was the first human to receive an insulin injection for diabetes

See the first dog ever treated with insulin—a peptide

Frederick Banting and his graduate student Charles Best were the first to isolate the peptide insulin from dogs. They induced diabetes in the animals and then treated them with this peptide.

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

An overview of 200 years of diabetes treatment

Diabetes treatment became truly effective after the advent of insulin injections in the early 1900s. Diabetes is becoming increasingly common. Current trends estimate one in three Americans will have diabetes by 2050. This overview explores two centuries of diabetes treatment—starting in 1812—and outline potential challenges to treatment and prevention.

Understanding insulin

Scientists Daniel and Kelly talk with researcher Dr. Katrine Whiteson about diabetes, the history of insulin production, and Dr. Lydia Villa-Komaroff—an essential member of the team who discovered that bacteria could be induced to produce insulin. Listen to discover interesting facts about the life-saving medicine and how it works in the human body.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

See different pig-to-human xenotransplantation possibilities

Xenotransplantation can include the insertion of any organ, tissue, cells or fluids from any nonhuman animal into a human. This US Food and Drug Administration graphic about pig-to-human applications shows different possibilities, including the exploration of using pig pancreatic cells for treating diabetes.

In 1933, the influenza virus was first identified through “ferret flu” experiments

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

12% of adults were taking injectable GLP-1 for weight loss according to 2025 survey

Weight loss injectable use rose sharply between 2024 and fall 2025. The percentage of adults who reported taking this class of medicine specifically for weight loss increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it.

Teddy Roosevelt was given a daily dose of saccharin

America's 26th president was prescribed a sugar-free diet by his clinician, so when the chief chemist for the US Department of Agriculture approached him with concerns about the product's safety in the early 1900s, the duo clashed over how to regulate it.

The first CRISPR-approved treatment was for sickle cell anemia in 2023

Victoria Gray was the first patient to receive a CRISPR-based therapy, which eliminated her symptoms and restored her health. The therapy's initial cost of $2.2M has kept it out of reach of many patients.

LSD was discovered accidentally after its inventor touched his face and hallucinated

Unlike many drugs, the first time a human ever tripped on acid was recorded first-hand by a scientist. Swiss chemist Albert Hofmann, curious about the "not unpleasant intoxicated-like condition" that overcame him after an accidental exposure, set up a rigorous experiment to test the drug's effects on himself.

Samuel O’Reilly patented the tattoo gun in 1891

Before the tattoo gun's invention, recipients sweated while artists slowly tapped or sliced designs into their flesh. The tattoo gun changed the field, helping artists ink clients’ skin at incredible speeds. Inventor Samuel O’Reilly applied the basic idea of an electric pen invented by Thomas Edison to his tattoo gun.

Knowing how to use an EpiPen is a life-saving skill—learn how with this video

If someone has a severe allergic response, including trouble breathing or two or more allergic symptoms, it may be necessary to administer epinephrine, usually through an injection. Epinephrine autoinjectors—often called EpiPens—should be injected into the mid-outer thigh, even through clothing, for about 10 seconds, depending on brand. Sometimes another injection with a separate EpiPen is required if the patient does not get better after a few minutes.

Watch this behind-the-scenes interview about the first person ever diagnosed with autism

Two reporters from The Atlantic tell the story behind their effort to track down the first diagnosed autism patient, Donald Gray Triplett, in Forest, Mississippi, and how his life turned out decades later.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Needle-free polio vaccines were offered in Afghanistan for the first time in 2026

Fear of needles has been one barrier to eradicating polio in Afghanistan. Vaccinators are now using a needle-free jet injector to deliver the vaccine through the skin—an approach that's previously been used in other locations. The inoculation includes the inactivated virus vaccine (the vaccine without any live virus in it).

The first ATM—dubbed a 'cash dispenser'—was installed in 1967 in London

Specifically, the first ATM (which stands for “automatic teller machine”) made its debut at a Barclays bank in London. A timeline of ATM history can help illustrate and visualize other key events in ATM history.

The term 'low T' was coined in 2002, recasting testosterone therapy and elevating demand

The marketing shift and accompanying awareness campaigns, both by the company behind the first testosterone product approved by the FDA, changed the landscape for testosterone product demand. Testosterone is often considered low when it's below 300 nanograms per deciliter of blood. (Some users may experience a paywall.)

Meet Icarus the Second, the first English pig to fly

"When pigs fly" is an ironic phrase meant to express disbelief or impossibility, though it isn't as true today as it may once have been. This article details how a piglet dubbed "Icarus the Second" took flight in November 1909. Stashed in a basket...

The first American roller coaster was built at Coney Island

LaMarcus Thompson was an inventor and businessman who developed the first US amusement park ride in the 19th century and sparked a booming business. Customers spent a nickel to coast on wheeled benches over gentle hills, leaving Thompson with around $600 per day in profits.

Sputnik 1—launched in 1957—was Earth's first artificial satellite

Its launch accelerated US investment in the Space Race amid fears the Soviet Union had the technology to launch intercontinental nuclear warheads. It would be followed by Sputnik 2, which carried the first living being—a dog named Laika—to orbit.

New Yorker John D. Sweeney Jr. was the first to receive a Social Security number

However, Sweeney died in 1974 having never received any benefits. Social Security numbers were first created to help track workers' earnings so Social Security benefits could be correctly administered.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real

The first robot in literature may have been a 'mechanical man' in 1907's 'Ozma of Oz,' a book in L Frank Baum's 'Wizard of Oz' series.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

Before writing 'Walden,' transcendentalist Henry David Thoreau nearly burned down his hometown with a campfire that grew out of control.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Watch a 1934 short film starring jazz legend Cab Calloway, a major figure in the Harlem Renaissance's music scene

In preparation for this weekend's Eurovision finale, which is something like the World Cup of pop music, here's a young Céline Dion performing (for Switzerland?) at the 1988 competition.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.