Learn about the US opioid crisis in this free course

From prescriptions to street drugs: Opioids trajectory across America

Exclusive data obtained by The Washington Post from the Centers for Disease Control and Prevention shows how individual counties moved through three waves of the opioid crisis, each wave paving the way for the next. Between 2011 and 2017, the drug responsible for the majority of overdose deaths shifted from prescription pills to heroin to fentanyl. Together, oxycodone, hydrocodone, heroin, and fentanyl have been major drivers in declining life expectancy in the US.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Opioid epidemic 101: lawsuits and settlements

State and local governments trying to address the opioid epidemic have sued organizations they believe started and supported the crisis. Companies that made, distributed, or contributed to sales of the highly addictive painkillers are expected to pay more than $50B in settlements. These settlements specifically state that at least 85% of settlement funds must be spent on addressing the epidemic, though where exactly the money is going is unclear.

The US war on drugs, explained

The United States has been fighting a global war on drugs for decades. By making drugs more expensive and less available, the US has sought to reduce drug use and inhibit the international drug trade. However, increasing prison populations,...

See how DOJ prosecutors took down a pharmaceutical company's executives over the opioid crisis

This FRONTLINE documentary follows federal prosecutors as they used anti-racketeering laws to convict executives at Insys Therapeutics, a pharmaceutical company that bribed doctors to overprescribe a fentanyl painkiller.

The science of addiction treatment

A helpful resource from the National Institute on Drug Abuse (part of the NIH). This article examines addiction treatment and recovery through the science behind several accepted methods. The guide draws helpful comparisons with other chronic disease treatments. In particular, it discusses the overlap between medications and therapeutic treatments, and the understanding that relapse doesn’t indicate treatment failure—only a need for continued or modified care.

Take Yale's free online course, 'The Science of Well-Being'

Considered Yale University's most popular free online course, this 10-module series offers insights into the science of well-being and practical ways to increase happiness and satisfaction. More than 5 million people have enrolled since its 2018 launch.

Princeton University offers a free online bitcoin course

Want to understand bitcoin and cryptocurrencies? A free online course from Princeton University unpacks the details of bitcoin, from how it works to what distinguishes it from other currencies, to the security and anonymity associated with its use. Explore explainer videos, or take the course as a series of lessons.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone, an opioid with distinct effects from heroin, revolutionized heroin addiction in the 1960s. Marie Nyswander was a psychoanalyst who helped discover the treatment process which is still in use today. Here's a podcast episode examining her life and role in the field of addiction treatment.

Explore US public health data

This resource tracks key US health metrics, including mortality causes, child survival rates, and life expectancy comparisons, to inform future health improvements, with regularly updated global estimates.

Mapping the spread of a dangerous fungus growing in US healthcare facilities

Explore the data showing how the fungus C. auris has spread in the US, with more than 10,000 reported cases since 2016. Recommended steps to prevent infections and limit their spread have been successful in some areas, but infection control remains complicated because the fungus is often now multidrug-resistant.

How did the pandemic affect mental health?

Read this research brief to learn more about why heightened mental health and substance use concerns persist three years after the outbreak of COVID-19. According to a recent survey, the vast majority of American adults view the nation as facing a...

'1440 Explores,' Episode 2: Why We Drink and What It Does to US

Alcohol is the world's most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol's journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

Ibogaine is being investigated for treating mental health issues and substance abuse

This compound, which is illegal to use in the US, has had promising results for patients who have tried it in other countries for substance abuse and mental health concerns. This psychoactive substance is not without risks, however; this TED talk points out it's also caused fatal cardiac arrhythmias and shouldn't be taken without medical supervision.

An encyclopedia of anthropology

This online database offers articles and additional resources for all things anthropology. This free resource is filled with peer-reviewed entries that cover topics ranging from addiction to writing, and offers anthropological insight into more...

A podcast on America’s coming demographic crisis

This podcast explores how America’s coming demographic crisis is bad for employers. According to Bloomberg, businesses still need humans to make the economy work. However, too few workers in the US are actually working, and too few people are...

'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

Many people with ADHD are prescribed stimulant medication to assist with symptoms ranging from time blindness to executive dysfunction. This hour-long podcast episode by Search Engine explores the host's experience with ADHD medication and the history of amphetamine and methylphenidate use in the US.

Some experts equate prediction markets to the new crack cocaine of gambling addiction

An addiction psychiatrist at UCLA says betting apps are far more potent than traditional gambling, citing a 19-year-old patient who lost $180,000 and hadn't left campus in a year, cycling through sports bets, crypto, meme stocks, and prediction markets on his phone. This interview explores the extreme edge of the nascent industry.

Support groups are typically free, which makes them widely accessible

The groups are typically run by someone with the same illness or set of experiences and can provide clear, practical knowledge about navigating healthcare resources, bureaucracy, and more. Since they function on trust, however, there are no legal confidentiality prohibiting people from sharing what's discussed. What's more, group leaders may not be uniformly trained or certified.

Accessing the dark web is legal in the US, the EU, and most countries worldwide

As long as users do not pay for illegal goods or services or acquire illegal content, they cannot be prosecuted. Those on the dark web include academics, researchers, and cybersecurity experts gathering threat intelligence on cybercriminals, cyberterrorists, and state actors, as well as protesters, activists, and grassroots organizers.

Telehealth demand for GLP-1s is booming as consumers seek easier access

Telehealth companies are rapidly expanding access to GLP-1s, but some doctors and researchers worry that these services are inadequately screening patients, skipping follow-up care, and prescribing cheaper compounded versions with little regulatory oversight—setting the stage for troubling medication errors and serious adverse events.

See Harvard’s early history through Indigenous voices

Founded in 1636, Harvard University grew alongside English colonization in Wampanoag lands. In this online exhibit, the Peabody Museum of Archaeology and Ethnology highlights Indigenous voices, interpreting objects such as eel traps and grass baskets.

Watch an expert's take on the rare disease hantavirus—and why it's not of great concern to the general population

This rare zoonotic disease, transmitted to humans primarily through infected rodent droppings, urine, or saliva, is rarely spread between people. The disease was of particular concern in spring 2026, when an outbreak occurred on a 150-person cruise ship, prompting a flurry of action, including contact tracing for passengers in their home countries. The disease can be fatal. But early care—primarily oxygen support—can help patients survive.

Learn the history and science of influenza in 'This Podcast Will Kill You'

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza’s biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

See the evolution of Ebola vaccine and treatment development.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

The United States has had a tumultuous relationship with Cuba since its 1959 revolution, highlighted by a nuclear crisis and a decades-long trade embargo.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The USPS spent $3.97B in 2024, accounting for .058% of the federal budget.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.