'1440 Explores,' Episode 2: Why We Drink and What It Does to US

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

The long history of alcohol and sports

Spectators have long enjoyed alcohol at sporting events, dating back at least to ancient Rome. This article unpacks how companies leveraged this history to make beer a central part of sporting events and masculine culture.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

'1440 Explores' Episode 3: Why We See Ghosts and What Isn't There

Every culture has them—restless spirits, haunted houses, things that go bump in the night. But why do we believe in ghosts? Psychologist and skeptic Dr. Chris French joins host Sony Kassam to explore the science behind the supernatural, from sleep paralysis and hallucinations to the brain's pattern-making instincts. Together, they uncover why our minds see meaning—and sometimes ghosts—where none exist, and what that reveals about fear, memory, and our need to believe in something beyond the grave.

Explore why Americans are drinking less alcohol

US alcohol consumption fell 5% in 2025, with beer and wine leading the decline. Economists point to tighter budgets and less face-to-face socializing overall, while younger Americans are increasingly choosing not to drink.

Tour the ancient world via beer

What did the people of yesterday make of beer, and how exactly did they make it? Explore the timeless beverage in this guide to ancient beers from around the world. Archaeological evidence suggests the rise of beer brewing may have coincided with humanity's shift from hunters to farmers. According to this article, beer was first enjoyed in ancient Mesopotamia, where paintings, poems, and myths glorified the porridge-like brew.

'The opposite of addiction isn't sobriety—it's human connection'

This thought-provoking TED talk from journalist Johann Hari challenges conventional wisdom about addiction, with a special focus on his global research investigating its root causes. Through personal stories and scientific evidence, Hari debunks some of the most common myths around addiction.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

Alcohol often accompanies memorial ceremonies around the world

“Pouring one out” for the dead is something that exists across the globe, in various cultures and forms. From the Irish wake to the Korean Sangnye, alcohol is frequently used as a way to honor the deceased and comfort the living.

Red wine, 101

How does a bottle of red wine get to the table? In this podcast episode from VinePair, tastings director Keith Beavers covers this wide-ranging wine category. Learn about the entire process of red wine production, from grape to glass. The episode provides a great starting line for general wine knowledge and a jumping-off point into individual varieties or regions.

A historical deep dive into everything coffee

Can’t get enough coffee? Join documentarian James Harper and historian Jonathan Morris for an immersive dive into the history of everyone’s favorite beverage. From the highlands of Ethiopia to the streets of Vietnam to Viennese cafes, you’ll travel with the humble coffee bean as it spreads across the globe.

Illinois rolled back its happy hour legislation in 2015, opting to cap reduced-price drink sales at 15 hours per week and prohibit them after 10 pm instead

In this episode of the podcast “The Right to Drink,” alcohol expert and host Jarrett Dieterle explains why some states allow happy hour while others don’t. The host also dives into the fight to change happy hour legislation across the US.

A video showing how drug dealing really works

What motivates people to sell drugs? The “News on Drugs” series asks how people get drawn into the drug trade, unpacking the different goals and aims involved in dealing drugs. While there is a lot of focus on cartels, traffickers, and gangs...

The Corps brought along an estimated 120 gallons of whiskey

To help them through the arduous trek, the Corps of Discovery brought the whiskey alongside wine, brandy, and rum for morale, trade, and medicinal use. Early on in the expedition, the adventurers reported frequent drunkenness.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

Toasting goes back to at least ancient Greece

The Greeks regularly held symposia featuring wine, food, music, entertainment, and intellectual conversation, hosted by a symposiarch, who acted as emcee. The wine was often drunk in honor of Dionysus, the god of wine and ritual madness, which often led to excess.

Watch Lin-Manuel Miranda tell the story of Alexander Hamilton on 'Drunk History'

On "Drunk History," Lin-Manuel Miranda retells Alexander Hamilton's life after the musical's success—revisiting the founding-era story that made Miranda famous, this time through the show's deliberately chaotic, comedic lens.

The debate on why humans are conscious—and what that means

Understanding what consciousness is, and why and how it evolved, is perhaps the greatest mystery known to science. Watch interviews with the world's leading experts on what it is and whether we'll ever know.

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

Many people with ADHD are prescribed stimulant medication to assist with symptoms ranging from time blindness to executive dysfunction. This hour-long podcast episode by Search Engine explores the host's experience with ADHD medication and the history of amphetamine and methylphenidate use in the US.

GLP-1 drugs are under investigation for treating Alzheimer's, Parkinson's, and drug addiction

Researchers are investigating GLP-1 applications for a variety of chronic conditions. One area of interest stems from how study participants using GLP-1 for diabetes and obesity reported describing less longing for wine and cigarettes while taking the medication—intriguing researchers about using the drugs for addiction applications. The drug, they theorize, could bind to receptors that mediate desire. (Some users may experience a paywall.)

The negative effects of cannabis use

After decades of criminalization, cannabis is a legalized drug in an increasing number of countries around the world. This allows for accurate, robust research on the drug's effects on humans . While weed isn't as harmful as alcohol, regular usage has its negative effects. As strains of the drug become stronger, so does its consequences. Watch this video for a lucid look at the effects of cannabis on its users.

'The urge to explore has propelled evolution since the first water creatures reconnoitered the land. Like all living systems, cultures cannot remain static; they evolve or decline. They explore or expire.'

- Astronaut Buzz Aldrin (1930-present)

Disneyland's drinkers once had their own unofficial mascot

Disney has countless subcultures and unofficial fan clubs, including D3, also known as the Disney Day Drinkers. Founded in 2021, the club began informally meeting near a trashcan, nicknamed Binny, in Disney World’s Epcot park … until it mysteriously disappeared in 2023.

Psychedelic compounds: a visual library

However psychedelic experiences manifest, they all begin with the presence of psychoactive compounds. Learn about their various chemical compositions in this structural library of psychedelic compounds. Clicking on an entry will take readers to a new page where they can learn about the chemistry and pharmacology of each compound, as well as the drug's possible applications.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Explore the animals that populate the depths of the ocean, from fish and coral in the first few hundred feet, all the way down to the bottom of the Mariana Trench.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.