The science of addiction treatment

The National Institute on Drug Abuse's resource library

The National Institute on Drug Abuse website is an in-depth and highly prolific resource on addiction science. Explore the vast scope of this website to access comprehensive guides, data visualizations, and educational materials on all facets of addiction and its treatment.

Addiction is defined as chronic compulsive drug use despite adverse consequences

This resource from the National Institute on Drug Abuse provides a comprehensive look at addiction as a complex brain disorder. It explores why people initially take addictive substances and how continued use alters the brain’s reward system.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

Social support plays a critical role in recovery from addiction

This engaging TEDx talk from addiction researcher Jacki Hillios explores addiction recovery through a transformative lens and Phoenix Multisport—an innovative program helping people rebuild their lives through active lifestyles. By living out its core message that people are not defined by their disease, the program demonstrates the power of social support in recovery.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

Alcoholics Anonymous leads to increased abstinence compared with other treatments

That's according to a 2020 meta-review of 27 studies. This large analysis found that Alcoholics Anonymous had between 22 and 37 percent abstinence numbers as compared to other treatments that had figures of about 15 to 25 percent. AA was founded in 1935, in Ohio, and depends on peer connections and consistent meeting availability. (Some users may experience a paywall.)

Naltrexone blocks the reward effects of alcohol and opioids

Naltrexone is used to treat alcohol and opioid dependence, blocking opioid receptors in the brain, reducing cravings, and preventing the euphoric effects of alcohol or opioids. It is nonaddictive and works best as part of a comprehensive treatment plan, including counseling or therapy, to support long-term recovery.

Explore the National Cancer Institute's archive on treatments

Cancer is a complex disease with many different types, each with its own pathology. The best treatment may depend on characteristics specific to each person—even if two people share the same type of cancer. No single overview of treatments exists, but this resource from the National Cancer Institute lets you explore different options, side effects, an A-to-Z library of cancer drugs, and much more.

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

Drugs 101: An interactive guide

What's the difference between opioids and psychedelics? This guide details specific drugs and their various associated effects. Drugs in this wheel fall into seven categories: stimulants, depressants, empathogens, psychedelics, dissociatives, cannabinoids, and opioids.

An animated short film portraying the arc of addiction

This simple yet profound award-winning animated short film uses the metaphor of a bird discovering golden nuggets to explore how addiction develops, with a special focus on the progressive nature of substance dependency. The film went viral, amassing nearly 30 million views by 2024.

Learn about the US opioid crisis in this free course

Where did the US opioid crisis come from, and how did it spread? Learn this and more in this free, online Harvard University course. Learn about the disease model of addiction treatment and management, and get up-to-date with public health and law enforcement's current harm reduction practices. This free resource gives users a greater understanding of opioid addiction and the epidemic still haunting the US.

What’s with the teen brain, anyway

In this video NIDA explores the intriguing similarities between the processes of brain development and computer programming. This analogy helps us understand why toxic environmental factors like drugs, bullying, or lack of sleep strongly affect a teenager’s life The information provided by this video can empower your children or students with information they need make better decisions.

GLP-1 drugs are under investigation for treating Alzheimer's, Parkinson's, and drug addiction

Researchers are investigating GLP-1 applications for a variety of chronic conditions. One area of interest stems from how study participants using GLP-1 for diabetes and obesity reported describing less longing for wine and cigarettes while taking the medication—intriguing researchers about using the drugs for addiction applications. The drug, they theorize, could bind to receptors that mediate desire. (Some users may experience a paywall.)

The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone, an opioid with distinct effects from heroin, revolutionized heroin addiction in the 1960s. Marie Nyswander was a psychoanalyst who helped discover the treatment process which is still in use today. Here's a podcast episode examining her life and role in the field of addiction treatment.

Stem cell therapies

Stem cells' special attributes interest researchers developing new therapeutic tools for a variety of health problems. Much of this research is done with support from the National Institutes of Health (NIH). This page offers a snapshot of research programs funded by the NIH and the health problems those programs focus on.

Learn about a new schizophrenia healthcare model that's making a difference

Schizophrenia used to be considered a progressive disease that was beyond a patient's ability to manage. This article gives an in-depth look at OnTrackNY, a New York-based program that empowers patients to define the goals of their own treatment for psychotic disorders. At the time of this 2022 article, it consisted of 25 affiliate clinics and hospitals in 14 New York counties, with another seven sites then slated to begin offering services in 2023.

The promises and perils of using at-home genetic tests for your health

A primer on genetic testing, personalized medicine, and the promise of pharmacogenomics–the use of genetics to predict an individual's response to a drug.

SAD 101 from the folks at NIMH—where the condition was first identified

Norman Rosenthal led the team at the National Institute of Mental Health that first identified and described seasonal affective disorder in 1984. This 101 from NIMH explores the basics of the condition, from who develops it to how it is treated.

Each scientific study adds incremental knowledge to existing understanding

On its own, no study serves as a source of truth or solves an existing problem indefinitely, though many can be analyzed collectively in a systematic review to build more confidence—the result of more data—in a conclusion. Studies can explore knowledge gaps or test an existing theory, which is always subject to refinement and improvement.

Who provides therapy is more important than what method they practice

What makes therapy work well is the connection that patients feel with their therapist, and the trust in that relationship. Some research suggests that while the therapeutic model—say cognitive behavior therapy or psychodynamic therapy—accounts for roughly 15% of outcomes, the therapeutic relationship with the therapist accounts for more than 30%.

How one autoimmune disease patient is questing for inflammation cures

This article's writer, who has Hashimoto's Disease and characteristic symptoms from her body attacking her thyroid—like exhaustion, hair loss, and brain fog—shares big take-aways from an anti-inflammatory retreat in Italy. The writer suggests that a holistic approach to eating, sleeping, and stress management, are the only sustainable ways to lower inflammation.

Eliminating distractions is essential to improving one's attention span

Setting a baseline, removing distractions, establishing focus rituals, taking breaks, and finding purpose in your task are five science-backed practices that can help address a short attention span. Bestselling author Daniel Pink breaks down how to approach each part of the plan and introduce these habits to your life today.

Comparing bioremediation with other treatment techniques, at three levels of complexity

Physical manipulation, such as collecting and moving contaminated material to a landfill, or chemical applications, which use strong, expensive substances and produce harmful byproducts, can be costly. While bioremediation leverages naturally occurring degradation processes that can be augmented without disrupting impacted ecosystems, these processes may be less effective in environments that bioremediation organisms are not adapted to.

See the evolution of Ebola vaccine and treatment development.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

This poison ivy knowledge quiz—accompanied by photos of the plant's varied forms—may help you identify this common rash-inducing growth.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Tattoos remain visible on your skin thanks to immune cells called macrophages

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

A century of Billboard issues documenting the evolution of popular music.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.