Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

The ancient Romans invented the first known artificial sweetener—it involved lead

The product was known as "sugar of lead." It was made by boiling wine in lead pots, concentrating the grapes' natural sugars and adding sweetness from the lead that leached into the grapes. The substance was used until roughly the 1880s for medicinal purposes and also to sweeten wine. (Some users may encounter a paywall.)

Fake sugars may disrupt metabolic health

Alternative sweeteners such as stevia and sucralose are 100 times sweeter than common table sugar. New research suggests these "high-intensity" sweeteners significantly disrupt the composition of the gut microbiome, affecting overall health. (Some users may encounter a paywall.)

Artificial sweeteners are considered safe for most people

These sugar substitutes are generally preferred because they are sweeter than sugar and can be used in smaller amounts while still getting a sugary taste. Though generally regarded as safe, sugar substitutes can cause flare-ups for individuals with bowel disease, and researchers are investigating how these substances affect gut microbiome health. Aspartame can also cause health issues for individuals with a rare genetic disease called phenylketonuria.

See how sugar stacks up against the sweetness of sugar alternatives

This US Food and Drug Administration graphic compares different approved sugar alternatives to give the public a sense of just how intensely sweet these sweeteners are compared to table sugar. Aspartame (NutraSweet and Equal), for example, is 200 times sweeter, Sucralose (Splenda) is 600 times sweeter, and Saccharin (Sweet'N Low) is between 200 and 700 times sweeter.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

Cats have a mutation preventing them from tasting sugar

When certain tastes (sweet, umami, bitter) become irrelevant due to a species' diet or lifestyle, the genes for those tastes degrade. In felines, scientists believe a shift to a protein-heavy diet put evolutionary pressure on the genes responsible for tasting sweetness. (Some users may encounter a paywall.)

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

LSD was discovered accidentally after its inventor touched his face and hallucinated

Unlike many drugs, the first time a human ever tripped on acid was recorded first-hand by a scientist. Swiss chemist Albert Hofmann, curious about the "not unpleasant intoxicated-like condition" that overcame him after an accidental exposure, set up a rigorous experiment to test the drug's effects on himself.

Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

No one's sure why it's spelled 'sundae'

There are several different folktales explaining the origins of the popular ice cream dish and its curious name. One claims an enterprising pharmacy used chocolate syrup instead of soda, which was banned on Sundays. Another claims the dish's unique spelling was to avoid offending religious folks who might object to an unholy reference to the Sabbath.

Acrylamide forms naturally during high-heat cooking through the Maillard reaction

While studies have shown it can damage DNA and potentially cause cancer in mice, humans absorb and metabolize acrylamide at different rates, introducing uncertainty in the research's applicability to humans. Some international health agencies have nonetheless recommended avoiding darker roasts when cooking starchy foods.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Before it was a drink, coffee was used for handwashing

Five centuries before the caffeinated drink was consumed, coffee beans were used for their aromatic quality. One 10th-century text explains how it "obliterates greasy smells of food on hands and whatever of sweets and fats. Whether traveling or at home, neglect not to wash your hands with it."

Sugar skulls are more than a sweet snack

The colorful candy combines Indigenous traditions with European confectionery techniques. Its symbolization reminds celebrants that death can be “sweet.”

Synesthesia: when sensation in one sense triggers an unrelated sense in the brain

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

Spontaneous metabolism may give clues to origins of life

Read this article to learn more about the discovery that suggests that metabolism could have begun spontaneously on our planet—and why it means that scientists may need to rethink how we define life’s origins. A team of researchers at the...

How a polluted New York City waterway created extremophiles hungry for 'black mayonnaise'

In the 19th century, coal processing plants, oil refineries, a tannery, and other industries lining the Gowanus Canal contaminated its waters with coal tar, sewage, and other pollutants, forming the toxic sludge. Samples taken from the site before clean-up efforts revealed over 450 species of microbes with metabolisms adapted to break down these contaminants.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

The unexpected origin story of the snow globe

In 1900, a Vienna tradesman named Erwin Perzy I was attempting to invent an inexpensive way to improve light amplification in hospital operating rooms. After experimenting with a glass globe filled with water, the idea for the snow globe struck. Industrious as well as inventive, Perzy eventually turned his idea into a successful business. Read the full article to learn how the invention grew to become recognized globally.

Who was behind the fatal 1982 Tylenol poisonings?

In 1982, an unknown suspect laced Tylenol packages with potassium cyanide in a Chicago pharmacy. Seven people were killed, and the case led to a nationwide panic, as well as the development of tamper-resistant packaging. No one was ever charged with the deaths, and the lead suspect died in 2023 after serving time in prison for trying to extort $1 million from a manufacturer to "stop the killing."

How five of the world's most expensive salt and spices are made

Part of the charm of certain spices and salts is their exotic origin, hailing from difficult-to-access locales or hewn via special processes. That also explains why they can be so expensive. Dive into the businesses of producing and marketing five of the world's most expensive food additives with this engaging video.

Candymaker Haribo focuses on gummies to simplify production

Focusing on a specific kind of candy gives the company expertise on texture, ingredients, factory processes, and more. The company's decentralized production allows for regional specification.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Browse a detailed visual analysis of over 200,000 similes—comparisons that often use 'like' or 'as'—from popular fiction to see how frequently writers the same idiomatic expressions.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology