The ancient Romans invented the first known artificial sweetener—it involved lead

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands

Saccharin, aspartame, and cyclamate all have origin stories from lab workers tasting something sweet on their hands. A Johns Hopkins University worker in the late 1800s, for example, tasted something sweet on his (unwashed or poorly washed) hands during dinner, prompting him to then taste everything on his lab bench in order to identify that the sweetness was a compound derived from his overheated coal tar—a substance he later named saccharin. (Some users may encounter a paywall.)

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Artificial sweeteners aren't very helpful for weight loss

Research published in 2014 from a randomized controlled study found that, on average, people only lost about two pounds if they switched to consuming artificial sweeteners instead of sugar. Some individuals using artificial sweeteners also have gained weight. Scientists theorize one potential explanation for this is that the sweeteners alter gut microbiomes in ways that reduce beneficial flora that would help promote digestion.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

A history of Rome and wine

Wine and winemaking were integral parts of everyday Roman life. Wine was used medicinally and for religious rites, as well as for pleasure. It also contributed to the expansion of the Roman empire as wine and grapes were traded throughout the Mediterranean. Roman winemaking practices spread as the empire grew. Without Rome, wine may never have grown into what it became, and vice versa.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

Xylitol, a sugar alcohol, is sometimes added to foods at 1,000 times the level seen naturally in foods

This article covers the latest research in sugar alcohols and heart health. Some work indicates that after consuming sugar alcohols erythritol or xylitol people are at an elevated risk of developing blood clots, which can cause heart attacks and strokes. Both substances occur in low levels naturally in fruits and vegetables and are also produced by the human body, but as sweeteners in foods they are present at exponentially higher levels.

Why it's so hard to end the use of toxic lead

Lead was one of the earliest metals mined on Earth, desired for its soft malleability and used in cosmetics, pipework, gasoline, and more. But even though researchers demonstrated its toxicity in the 20th century, much of the world still uses it.

Vanilla was originally thought to be an additive for chocolate

The classic flavor didn't stand on its own until the 17th century, when Queen Elizabeth I's apothecary began intentionally making vanilla sweets.

Aspirin was the first synthesized anti-inflammatory drug

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The term 'alcohol' has Arabic origins

Linguistic research reveals a lot about the ancient origins of alcohol. For example, studying various languages reveals that "mead," an alcoholic beverage made from honey, came even before wine.

The vast majority of Champagne is labeled 'dry' or even 'extra dry'

Sweetness levels are determined by the amount of sugar added to the wine at the end of the process—anything up to 6 grams per liter is extra dry, and up to 12 grams per liter is still considered dry.

The drink that became Coca-Cola was originally called 'Pemberton's French Wine Coca'

When Civil War veteran John Pemberton concocted the drink, he was suffering from both a saber wound and a morphine addiction. He formulated Pemberton's French Wine Coca by copying the popular cocaine-infused Vin Mariani wine that Popes and Presidents drank at the time. This podcast episode details Coca-Cola's origin story, as well as the financial and business strategies it used to get to where it is today.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Eduard Baltzer encouraged 'natural eating' in the 1860s

Historian Corinna Treitel credits the Protestant minister with inventing the concept of “natural eating” in Nordhausen, Germany, in the 19th century. Baltzer believed that people were consuming excessive amounts of schnapps, sugar, and meat, and that this behavior was having a detrimental impact on their lives. He encouraged a diet mostly of fruits and vegetables, though he was not opposed to food grown with artificial fertilizers.

Roman concrete lasts longer than modern recipes—and even gets stronger

Today's concrete is made by binding ingredients, including chalk and silica sand, at high temperatures. Unfortunately, it weakens when exposed to salt water. This article explores how and why scientists are studying ancient Roman concrete, which grows stronger when exposed to salt water.

Ancient Rome had an early version of macaroni and cheese

Called placenta (with a hard "c"), the holiday dish consisted of sheets of rolled-out dough layered with cheese. It is the first recipe documenting the combination of the two elements. While there is debate about whether the dough can be called pasta because it's not boiled, many scholars view the dish as a proto-lasagna.

The centuries-old history of titanium white goes back to the Inca

Titanium white can be found in items ranging from paint to pills. Though it was created in New York in 1908, the pigment was first used hundreds of years earlier by the Inca, according to this article.

Watermelons were once neither red nor sweet

The gargantuan summer picnic staple has a fascinating story: 100 million tons are produced worldwide and they take up the most space of any vegetable crop in the world. But not long ago, the flesh of the melon was white and it had a bitter taste.

A Spanish New Year's Eve tradition is eating 12 grapes at midnight

When midnight hits, participants in Spain, as well as Mexico and some Latin American countries, are encouraged to eat a grape for each of the clock’s strikes. (We’re assuming they’ve got some nice grandfather clocks!) The tradition is intended to bring good luck in the new year. The idea is believed to have originated in the 1890s, but took off when Spanish grape farmers had a surplus harvest.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

The colorful history of the world's first gummy bears

Hans Riegel Sr. founded Haribo in 1920, creating the world's first gummy bears in 1922. Initially working from his kitchen in Bonn, Germany, Riegel developed the Dancing Bear, which was larger and slimmer than modern gummy bears, inspired by dancing bears at European festivals. Haribo has continuously evolved, creating unique gummy products for different countries and addressing ethical concerns. Learn the history here.

How fermentation enables the pickling of food and the production of beer

This process occurs when microbes produce lactic acid, ethanol, or carbon dioxide after consuming sugars. The acid helps preserve vegetables in a brine solution during pickling and gives them a sour taste, while ethanol serves as the inebriant in alcoholic beverages. The acid and carbon dioxide give sourdough bread its taste and texture.

Ancient Egyptian papyrus from 16th century BCE seems to reference tinnitus

Ancient Egyptians wrote that they treated "bewitched ear" with herbal concoctions that involved frankincense and other ingredients, which were placed in the ear.

A dispute about the origin of twitching frog legs led to the invention of the first battery

Experiments by Luigi Galvani on exposed frog leg nerves showed activity when they were hung from iron railings and brass hooks, suggesting the existence of "animal electricity" that discharged when connected to metals. Alessandro Volta's voltaic pile, which stacked metals with an inorganic electrolyte, showed that electricity originates from chemical reactions.

Check out George Washington's beer recipe

The first American president's journal includes a recipe for "small beer," a low-alcohol beverage that was a cleaner (and slightly inebriating) alternative to the potentially sickening water of the time.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.