Fake sugars may disrupt metabolic health

Artificial sweeteners may disrupt gut health

Some research suggests that certain sweeteners can throw off the balance of beneficial bacteria in the gut and shift the composition of the microbiome. Such changes, depending on an individual's specific gut flora and levels of sweetener consumption, could potentially affect metabolism and glucose tolerance or lead to bloating and diarrhea.

Artificial sweeteners are considered safe for most people

These sugar substitutes are generally preferred because they are sweeter than sugar and can be used in smaller amounts while still getting a sugary taste. Though generally regarded as safe, sugar substitutes can cause flare-ups for individuals with bowel disease, and researchers are investigating how these substances affect gut microbiome health. Aspartame can also cause health issues for individuals with a rare genetic disease called phenylketonuria.

Artificial sweeteners aren't very helpful for weight loss

Research published in 2014 from a randomized controlled study found that, on average, people only lost about two pounds if they switched to consuming artificial sweeteners instead of sugar. Some individuals using artificial sweeteners also have gained weight. Scientists theorize one potential explanation for this is that the sweeteners alter gut microbiomes in ways that reduce beneficial flora that would help promote digestion.

See how sugar stacks up against the sweetness of sugar alternatives

This US Food and Drug Administration graphic compares different approved sugar alternatives to give the public a sense of just how intensely sweet these sweeteners are compared to table sugar. Aspartame (NutraSweet and Equal), for example, is 200 times sweeter, Sucralose (Splenda) is 600 times sweeter, and Saccharin (Sweet'N Low) is between 200 and 700 times sweeter.

Sugar alcohols, a type of carbohydrate used as a sweetener, may elevate risk of heart attacks and strokes

Sold as erythritol, sorbitol, xylitol, and mannitol, these products—ones that aren't actually sugars or alcohol—are found naturally in certain fruits and vegetables. They are synthetically produced to be used at much higher levels as the sugar alternatives for sugar-free candies, cookies, and chewing gums. Erythritol and xylitol have been linked with elevated heart attack and stroke risks.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands

Saccharin, aspartame, and cyclamate all have origin stories from lab workers tasting something sweet on their hands. A Johns Hopkins University worker in the late 1800s, for example, tasted something sweet on his (unwashed or poorly washed) hands during dinner, prompting him to then taste everything on his lab bench in order to identify that the sweetness was a compound derived from his overheated coal tar—a substance he later named saccharin. (Some users may encounter a paywall.)

The dark side of modern sugar production

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

Stevia is a plant-derived sweetener but the plant isn't approved for eating

Steviol glycosides, the sweet-tasting stuff in the plant leaves, are purified and highly processed before they end up in the food or drinks sold in stores. The US Food and Drug Administration does not allow the use of stevia leaf or crude stevia extracts in food, and the agency also bars them from being imported into the US for use as sweeteners.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

Cats have a mutation preventing them from tasting sugar

When certain tastes (sweet, umami, bitter) become irrelevant due to a species' diet or lifestyle, the genes for those tastes degrade. In felines, scientists believe a shift to a protein-heavy diet put evolutionary pressure on the genes responsible for tasting sweetness. (Some users may encounter a paywall.)

Gummy vitamins have candy-level sugar—and that sweetness is linked to overdoses

A typical gummy vitamin contains about the same amount of sugar in a single serving as one Sour Patch candy. It's linked to the increase in pediatric overdoses for products including multivitamins and melatonin. Gummy formulations also degrade quickly, so they often include much higher levels of the product in each serving than the label advertises—boosting overdose risks due to this unchecked variability. (Some users may experience a paywall.)

Read this analysis indicating which traditional stevia medical uses have scientific evidence

This research paper investigates the various uses of Stevia rebaudiana leaves and their extracts and concludes that the substances do hold significant potential for improving cardiovascular health and inflammatory disorders in adults, among several other potential applications. Its authors suggest that further research should examine safe dosage questions and chronic disease management approaches.

Investigation finds 'influencer' dietitians paid to promote sugar, supplements on social media

A joint investigation by The Examiner and The Washington Post found that food, beverage, and supplement corporations and groups have paid registered dietitians on social media to promote content that goes against decades of scientific evidence on...

The myth of sugar rushes vs. the reality of sugar crashes

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

Can the gut microbiome drive addiction?

New research suggests an imbalance of gut microorganisms may influence the likelihood of addiction and addictive behaviors by increasing the severity of withdrawal symptoms, triggering brain inflammation in regions of impulse control, and more.

The lack of guidance on getting off GLP-1s leaves patients at risk

Dr. David Kessler, former FDA Commissioner and public health leader, explores how these drugs override the brain’s reward-driven eating habits but have notable side effects. These include developing eating disorders, muscle loss, and intestinal obstruction.

Kava, kratom, St. John's Wort, and green tea extract present health concerns

Consumer Reports, which tests supplements for safety, urges consumers to avoid these four supplements due to safety warnings from researchers and public health authorities.

Ultraprocessed foods include preservatives, dyes, sweeteners, and more

Processed foods are those that have been altered from their original state, which includes numerous processes that we consider natural, such as cooking or salting. Ultraprocessed foods contain at least one item that wouldn’t be found in a kitchen, like hydrogenated oils or high-fructose corn syrup. It’s estimated that nearly 75% of all foods consumed in the US are ultraprocessed, though that doesn’t mean that all of them are unhealthy. In fact, some, such as prepackaged whole wheat bread and soy milk, are recognized for their health benefits.

Microplastics are infiltrating the human body with unclear but concerning effects

Scientists have linked microplastics to immune system damage, hormone disruption, inflammatory diseases, and even cancer—yet most of their health impacts remain unknown due to limited research. Studies suggest we ingest about a credit card's worth of plastic weekly.

Organic food might be greener, but it’s not better for you

Weighing in on the ongoing debate surrounding organic versus “regular” foods, health experts explain whether organic foods offer significant health benefits. Studies suggest that organic foods have little additional nutritional value compared to...

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Efficiency of commercial honeybees may exacerbate population declines in native bees

Commercial beekeepers are increasingly breeding honeybees on public lands, raising concerns among environmentalists that they’ll compete with and introduce new diseases to already threatened native pollinator populations. However, native species alone are often unable to meet the pollination levels required to meet necessary crop yields.

Supplements ahead of exertional heatstroke helped protect mice against brain damage

In the lab, mice dosed with probiotics prior to inducing exertional heatstroke, had better cognitive outcomes. This evidence underscores the links between the gut microbiome and the brain, at least in rodents.

Acrylamide forms naturally during high-heat cooking through the Maillard reaction

While studies have shown it can damage DNA and potentially cause cancer in mice, humans absorb and metabolize acrylamide at different rates, introducing uncertainty in the research's applicability to humans. Some international health agencies have nonetheless recommended avoiding darker roasts when cooking starchy foods.

Can we speed up our metabolisms?

Listen to this 31-minute podcast to better understand what science knows and doesn't know about metabolism, as well as the only thing that seems capable of changing it. Scientists understand that the difference between a so-called “fast” and “slow” metabolism does not affect one’s ability to lose weight.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Beanless 'coffee' is an eco-friendly alternative

As we consider the role of agriculture in climate change, many people are seeking alternatives to the most resource-hungry crops—coffee included. Are new synthetic alternatives the answer? Startups are exploring beanless “coffee” made in a variety of ways.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

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Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

A century of Billboard issues documenting the evolution of popular music.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Browse a detailed visual analysis of over 200,000 similes—comparisons that often use 'like' or 'as'—from popular fiction to see how frequently writers the same idiomatic expressions.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.