Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

The WHO labeled aspartame as 'possibly carcinogenic' but US regulators consider it safe

The International Agency for Research on Cancer, an arm of the World Health Organization, labeled aspartame—the artificial sweetener in Diet Coke—as one of several hundred possible cancer-causing substances in 2023. The determination was based on animal and human studies and "limited" evidence linking it to liver cancer. The WHO and US Food and Drug Administration both say the substance is safe at moderate levels. The FDA says a person weighing about 132 pounds would need to have 75 packets daily to reach an unsafe level.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands

Saccharin, aspartame, and cyclamate all have origin stories from lab workers tasting something sweet on their hands. A Johns Hopkins University worker in the late 1800s, for example, tasted something sweet on his (unwashed or poorly washed) hands during dinner, prompting him to then taste everything on his lab bench in order to identify that the sweetness was a compound derived from his overheated coal tar—a substance he later named saccharin. (Some users may encounter a paywall.)

Fake sugars may disrupt metabolic health

Alternative sweeteners such as stevia and sucralose are 100 times sweeter than common table sugar. New research suggests these "high-intensity" sweeteners significantly disrupt the composition of the gut microbiome, affecting overall health. (Some users may encounter a paywall.)

Teddy Roosevelt was given a daily dose of saccharin

America's 26th president was prescribed a sugar-free diet by his clinician, so when the chief chemist for the US Department of Agriculture approached him with concerns about the product's safety in the early 1900s, the duo clashed over how to regulate it.

Stevia is a plant-derived sweetener but the plant isn't approved for eating

Steviol glycosides, the sweet-tasting stuff in the plant leaves, are purified and highly processed before they end up in the food or drinks sold in stores. The US Food and Drug Administration does not allow the use of stevia leaf or crude stevia extracts in food, and the agency also bars them from being imported into the US for use as sweeteners.

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Rachel Carson didn't argue for wholly organic farming

Her 1962 book, “Silent Spring,” inspired many people to consider the chemicals used to grow their food, but Carson didn’t think that manufactured fertilizers needed to be banned from farming, writing that “The ultimate answer is to use less toxic chemicals so that the public hazard from their misuse is greatly reduced.” When she testified to Congress in 1963, she said, “I think chemicals do have a place.”

Overmedication has put type 2 diabetics at risk of low blood sugar

Type 2 diabetics in the US risk dying from low blood sugar, an epidemic traced to a decades-old, multi-million-dollar drug industry campaign encouraging an average blood sugar level below 7%. Contemporary research correlated such levels with reduced risk of eye, nerve, and kidney damage and increased hypoglycemia risk.

Following the scandals, CBS briefly banned canned laughter

The network was looking to correct the public perception that its programming was fraudulent, so it banned laugh tracks and fake applause from its broadcasts. The policy didn’t last long; within a few years, sitcoms were regularly “sweetened” with the sound effects.

Food companies are exploring 'GLP-1 friendly' diet labels

Producers of foods like Healthy Choice frozen meals are placing "GLP-1 friendly" labels on their food, but there's no regulation about what that label means. Nutritionists say that GLP-1s can help reduce appetite, but healthy, balanced diets are a necessary complement to the medications. Data shows that about half of GLP-1 users quit these medications within a year and then rapidly regain weight, underscoring the importance of also prioritizing healthy eating.

Sugar skulls are more than a sweet snack

The colorful candy combines Indigenous traditions with European confectionery techniques. Its symbolization reminds celebrants that death can be “sweet.”

Dietary supplements are regulated like foods

This hour-long 2016 documentary from Frontline, the Canadian Broadcasting Corporation, and The New York Times examined the safety of dietary supplements. It noted that this then-$30B industry (it's at least doubled since then) suffers from irregularities and impurities. It warned that many Americans are unaware of the lack of regulatory oversight over these products.

Sesame seed regulations have led to fewer sesame-free products

Food producers have been required to include specific labeling on their packages for sesame since new regulations went into effect in January 2023. In response, some food producers have decided to add small amounts of sesame to foods, including breads, rather than do the costly work of scrubbing their facilities of all possible sesame contamination.

Peanut allergies dropped by 43% after doctors reversed avoidance guidance, but questions remain

The study’s data appear to confirm the policy shift. Still, since the study did not include an examination of infant diet, researchers can’t definitively say that the guideline shift led to dietary changes and thus directly caused the decline.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.

The 'playing card' and 'blueberry' taxes are among the strangest around the world

In Canada, companies making children’s breakfast cereals are granted a tax exemption if their cereal boxes contain free toys. While the exemption is limited to toys that are not “beer, liquor, or wine,” the cereal tax is far from the world's most eccentric tax.

Stainless steel and cast-iron pans should be used over older nonstick cookware

Although modern nonstick pans avoid forever chemicals like PFOA, they were previously used in the manufacturing of Teflon coatings and have been linked with certain types of cancer, infertility, and other adverse health outcomes. Vintage plastic utensils should also be avoided due to the leeching of contaminants in early formulations of plastic.

The Sears catalog sold some weird products before it folded, including drugs

At various times in its existence, the Sears catalog sold everything from heroin to tombstones. But by the 2000s, the catalog was no longer in publication.

Premarin was the bestselling drug in the US in 1992

The drug, derived from the urine or pregnant mares, raised ethical and animal welfare concerns, but also became wildly popular until the Women's Health Initiative study findings in 2002 (which have since been largely disproved). In the 1990s, Premarin was used to treat menopause symptoms and also to protect against osteoporosis and heart disease among older women.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

70 years ago today, city officials in Santa Cruz, California, banned rock 'n' roll to protect its youth from corruption after witnessing a 'provocative' concert the night before.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

'Silent' fireworks have gained more interest in recent years as a quieter celebratory option.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

In its famous catalog, Sears sold $600 DIY house kits from 1908 through the 1940s, resulting in an estimated 100,000 'Sears and Roebuck homes.'

In preparation for this weekend's Eurovision finale, which is something like the World Cup of pop music, here's a young Céline Dion performing (for Switzerland?) at the 1988 competition.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

Comedy legend Catherine O'Hara, star of 'Schitt's Creek' and 'Home Alone,' quit 'Saturday Night Live' after just one week to return to her old job.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

Mark Twain spent decades feuding with the US Postal Service, convinced its costs and regulations were bureaucratic overreach.