A major US-designed polio vaccine was first tested in the Soviet Union

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

Inactivated polio virus vaccine is the only one offered in the US—it contains no live virus

Inactivated polio virus vaccines cannot cause illness because the virus isn't alive. It's been the only polio inoculation offered in the United States since 2000 and provides almost complete protection

Oral polio vaccines cause approximately 250 to 500 polio cases per year globally

Live, weakened polioviruses in the oral vaccine can very rarely mutate into a disease-causing form and lead to vaccine-associated paralytic poliomyelitis. This oral vaccine is not available in the United States.

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

The oral, live virus vaccine is the most robust but carries more risks

The live virus vaccine, delivered via oral drops, induces the best protection in the body. Because it includes a live, weakened form of the virus there's an extremely small risk it can sicken recipients and potentially cause paralysis. Recipients also shed the virus in their stool, which can rarely lead to vaccine-derived cases of the virus if the virus mutates. (Some users may experience a paywall.)

Needle-free polio vaccines were offered in Afghanistan for the first time in 2026

Fear of needles has been one barrier to eradicating polio in Afghanistan. Vaccinators are now using a needle-free jet injector to deliver the vaccine through the skin—an approach that's previously been used in other locations. The inoculation includes the inactivated virus vaccine (the vaccine without any live virus in it).

Wastewater testing has detected genetic evidence of polio, triggering vaccine boosters

Sampling of wastewater in London in 2022 detected fragments of polio virus, suggesting a vaccine-derived version of polio may be circulating. No one became ill, but the finding did trigger calls for a renewed booster inoculation campaign.

Improved 19th-century sanitation meant kids encountered polio later, with worse results

Almost all children likely used to contract poliovirus, but scientists suggest that when infants encountered it very early in life—due to poorer conditions and hygiene—they still had some maternal protection from pregnancy or through breastmilk, so the symptoms were more flu-like.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

The US military, concerned about potential deployments worldwide, has long funded experimental hantavirus vaccines and therapies.

Collaborations between the military, biotech, and academic researchers led to an experimental antibody treatment for the Andes hantavirus strain—the one that more readily passes between humans. As of spring 2026, it had only been tested in animals. The US Army has also tested a potential hantavirus vaccine in people. It published early findings in 2023 that seemed promising, eliciting some immune system response. (Some users may encounter a paywall.)

During the Cold War, the Soviet Union created a Eurovision competitor

The Soviet Union was not a member of the European Broadcasting Union, so it couldn't compete in Eurovision. In 1977, it turned a preexisting Polish-language singing competition into one that more closely resembled Eurovision and renamed it Intervision. The competition was open to countries from across the globe, regardless of their form of government, though most entrants were from communist countries.

Spies working on the Manhattan Project propelled the Soviet bomb program

Soviet infiltration—most notably by Klaus Fuchs—smuggled detailed implosion-design and hydrogen‑bomb data from Los Alamos to Moscow, cutting the USSR’s development time by at least a year and enabling their first atomic test in August 1949.

Sputnik 1—launched in 1957—was Earth's first artificial satellite

Its launch accelerated US investment in the Space Race amid fears the Soviet Union had the technology to launch intercontinental nuclear warheads. It would be followed by Sputnik 2, which carried the first living being—a dog named Laika—to orbit.

The measles vaccine has saved an estimated 94 million lives since its introduction

Measles killed an estimated 2.6 million people globally in 1980, after the development of a vaccine but before its widespread dissemination. By 2014, that figure had dropped to an estimated 73,000.

A fake vaccine campaign was used to locate Osama bin Laden, fueling vaccine distrust

As part of the intelligence operation to find bin Laden in Pakistan, the US Central Intelligence Agency recruited a Pakistani doctor who ran a fake hepatitis B vaccine campaign and obtained DNA samples from bin Laden. News of this fake campaign fueled further distrust of healthcare workers, attacks on them, and stymied efforts to vaccinate against polio in the region.

Sparkling wine was a political tool in the Soviet Union

To show the world that the Soviet Union had recovered after the devastating famine of the early 1930s, leader Josef Stalin turned to a surprising source: sparkling wine. Stalin believed that if everyday citizens could access luxury goods like caviar and Champagne, it would show socialism had succeeded. The result was Sovetskoye Shampanskoye, a Soviet-made sparkler that achieved his goal of availability and affordability if not quality.

What are universal vaccines?

As viruses mutate and develop, vaccines have to adapt, leading to regular recommended injections like flu shots. Researchers are working to develop universal vaccines that aim to protect against multiple virus variants if not entire virus families. These vaccines work by creating broadly neutralizing antibodies (bnAbs) that target aspects of viruses that don't typically mutate and are integral to the virus' survival.

An Ebola vaccine was developed during the 2018 west African Ebola outbreak, but the 2026 Ebola outbreak is with a different species of the virus, not the one that the vaccine is approved to treat.

The US and the USSR each boycotted Olympic Games during the Cold War

The US led a boycott of the 1980 Moscow Olympics over the Soviet invasion of Afghanistan. In retaliation, the USSR and its allies skipped the 1984 Los Angeles Games.

There are two recommended malaria vaccines

Two vaccines are currently recommended by world health experts for children living in areas where malaria transmission is common. The first, RTS,S/ASO1, formally became recommended for use by the World Health Organization in October 2021, and the second was approved by the WHO two years later. Both have faced logistical, financial, and uptake challenges.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

It took 14 years to deploy penicillin after its discovery

Despite its promise, US production of penicillin remained minimal in 1942—enough to treat fewer than 100 patients nationwide. Within two years, output expanded into millions of doses to supply troops for D-Day.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Watch an American news report of the Chernobyl disaster

Americans first heard about the Chernobyl nuclear disaster two days after the event, once abnormal radiation was detected in nearby countries. This forced Soviet officials to acknowledge the catastrophe publicly for the first time a few days after it occurred.

A 36-year-old Russian physicist survived a particle accelerator beam to the head

Several safety mechanisms failed during Anatoli Bugorski's inspection of malfunctioning equipment at the U-70 synchrotron, the Soviet Union's largest particle accelerator. Despite receiving as much as 600 times the lethal dose of radiation to the brain, he has shown no intellectual damage and worked until the age of 77.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

Epstein-Barr virus—the cause of 'kissing disease' mononucleosis—may be the leading cause of MS

A Harvard study with data from more than 10 million US military personnel found that people that contracted Epstein-Barr virus had a roughly 32-fold increased risk of developing multiple sclerosis. The work, published in 2022, found that Infection of the virus preceded MS onset by a median of five years, raising questions about better Epstein-Barr virus management and potential disease prevention.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

Walt Disney's early film 'Alice's Wonderland' was a groundbreaking innovation in the silent film era

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.