It took 14 years to deploy penicillin after its discovery

Penicillin production was just behind the atom bomb in wartime priorities

By 1943, the US War Department made penicillin its second-highest priority—just after the Manhattan Project. Producing enough of the antibiotic for the D-Day invasion became a central mission of Allied science and industry.

Penicillin supplies were ready for every wounded soldier on D-Day

By June 1944, Allied stockpiles included 2.3 million doses of penicillin—enough to ensure that every soldier wounded during the pivotal Normandy landings could receive treatment.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Penicillin slashed battlefield pneumonia deaths during World War II

Before antibiotics, bacterial pneumonia killed about 18% of infected soldiers in World War I. By World War II, penicillin cut that death rate to less than 1%.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Penicillin has saved an estimated 500 million lives since its creation

Since its introduction in the 1940s, penicillin and related antibiotics are estimated to have saved around 500 million lives worldwide—making it one of the most consequential medical breakthroughs in human history.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

It can take 10 to 15 years and more than $1B to develop a new antibiotic.

Why don't we just develop new antibiotics? In part, it's a complex scientific challenge, but market incentives also play a significant role. It can be time consuming, expensive, and most notably, we should use as little as possible to avoid driving further antibiotic resistance.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

The food processing techniques developed for World War II, later repurposed for consumers

Research projects funded or sponsored by the military led to the development of active dry yeast to make bread easier to bake and an improved version of dehydrated cheese, which would be used in powdered cheese snacks. Freeze-drying, which had been used to ease the transport of blood plasma to battlefields, where it would be reconstituted with water, was later used on fruit for cereals.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Peptide research dates back to the late 1800s

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

After World War II, pizza took off in the US

Pizzerias opened in cities throughout the 1920s and '30s, especially those with large Italian immigrant populations, but the cuisine didn't take off nationally until after World War II. Some credit that with American soldiers' exposure to the food while stationed in Italy; others point to the invention of the mass-produced gas-fired ovens, which made opening a pizzeria considerably easier. Below is a 1944 clip from the New York Times, the first time the paper mentioned pizza.

Before Pearl Harbor, the US was a nonbelligerent ally to the Allied powers

Between September 1940 and December 7, 1941, the United States remained officially neutral—yet President Roosevelt incrementally shifted policy from “cash‑and‑carry” to Lend‑Lease, funneling critical military aid to Britain and other allies without entering the war.

Up to 225 cases of leprosy in the US are diagnosed each year

Most cases in the US are imported, meaning someone was infected in a country where it was more common. Since symptoms can sometimes take decades to appear, tracing the origin of the disease can be hard.

Testosterone prescriptions remain very low overall

Though demand for an injectable formulation of testosterone roughly doubled between 2019 and 2025, testosterone prescriptions still remain very uncommon—adding up to less than 2 per 100,000 prescriptions in 2025.

Scientists still don't know why DEET is such an effective bug repellent

This chemical, used to keep ticks, fleas, mosquitoes, and other nuisance bugs away, is used by an estimated one-third of the US population and has been available to consumers since 1957. Researchers theorize that multiple mechanisms may be at work to deter bugs, including perhaps masking or confusing bugs' olfactory receptors.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.

How nylon was created

Nylon, one of the most ubiquitous materials in the world, was invented in 1935. Chemist Wallace Carothers was hired by American conglomerate DuPont to perform research. After seven years of work he produced nylon, the first wholly synthetic fabric. Carothers’ life ended tragically, but his contributions revolutionized everything from military equipment to women’s fashion.

How much did WWII cost?

Though it lasted fewer than four years, World War II was the most expensive war in United States history, according to this infographic. Read through it to see how much WWII cost and learn about the consequences of financing such an expensive conflict.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

Germany’s surprise offensive in December 1944 failed to break Allied lines

In a bold counterattack from December 16, 1944, to January 28, 1945, Hitler committed over 400,000 troops in a surprise “Bulge” through the Ardennes forest in France. Although initially successful in creating a 50‑mile incursion, Allied defense halted the advance. German forces suffered irrecoverable losses (~100,000), while Allied casualties totaled ~75,000, marking the offensive as the last major German gamble and a decisive step toward Nazi defeat.

President Trump ordered an end to US production of the penny in 2025

The US will stop producing pennies after more than 233 years in 2026, though they will still be considered legal tender. It takes roughly three cents to produce a single penny, with an annual price tag of nearly $100M.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

See the most iconic photos from four decades of LIFE magazine

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Brian Wilson wrote the Beach Boys' 'Don't Worry Baby' for the Ronettes, but the legendary girl group rejected it.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.