Peptide research dates back to the late 1800s

Early peptide research focused on isolating the substances from animal tissue

In the first half of the 20th century, peptides including insulin and adrenocorticotropic hormone were isolated from animals to provide life-saving medicines. ACTH was isolated from the pituitary glands of cows and pigs and insulin was isolated from the pancreas of dogs and cows.

See the first dog ever treated with insulin—a peptide

Frederick Banting and his graduate student Charles Best were the first to isolate the peptide insulin from dogs. They induced diabetes in the animals and then treated them with this peptide.

Peptides may have predated ribosomes—the cell's protein factory

Some scientists have hypothesized that peptides and RNA molecules may have coevolved as a single, mixed "chimeric" molecule, fueling the beginning of protein production and predating a primitive version of the ribosome. All life today uses ribosomes to make peptides. (Some users may experience a paywall.)

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Peptides account for 31 of 370 new drugs approved by US FDA between 2016 and 2023

Among the approved peptide-based drugs is the first-ever treatment for Rett syndrome, a rare inherited neurologic disorder that leads to a progressive loss of motor skills and language. Peptides are particularly attractive for multiple reasons, including their ability to selectively bind to cellular receptors to either activate or inhibit their function.

Diabetes drug GLP-1 is a peptide (that's what the 'P' is for)

Glucagon-like peptide-1, or GLP-1, is one of the most well-known peptides in common use. In 2024, 26.5% of all adults with diagnosed diabetes used the substance. GLP-1 was particularly popular among people with diabetes aged 50-64, followed by younger adults and then seniors aged 65+.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The word peptide comes from Greek

Originating from the Greek term "peptos," which means digestible, peptide as a word refers to two or more amino acids. (Some users may encounter a paywall.)

China is producing many peptides or peptide components sold in the US

In Silicon Valley, in particular, peptides have taken off, and are often coming from China—even though many of the products are unproven for their purported uses.

The US FDA issued a 2025 warning about BPC-157 and other popular peptides

BPC-157, which mimics a naturally occurring gut peptide involved in soft tissue repair, has been marketed for various regenerative properties. But the FDA warned in July 2025 that it doesn't have enough data to assess its safety in humans and that such products may also pose risks related to contamination.

Cross-species transplantation has been attempted in medicine for more than 300 years

Early reported xenotransplantation attempts included 17th century efforts in France to transfuse blood from animals into humans. The poor results prompted France to issue a xenotransplantation ban. In the 19th century, researchers tried animal-to-human skin grafts from species including sheep, rabbits, dogs, cats, rats, chickens, and pigeons.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The first prenatal screen for disease was developed in 1961

Scientist Robert Guthrie created a method to test newborns for a metabolic defect called phenylketonuria, or PKU. This blood test didn't look for gene variants—it hunted for excess phenylalanine in the blood. The disorder is caused by an inability to digest the amino acid phenylalanine, leading to excess phenylalanine in the body. PKU results in intellectual disability, seizures, and other symptoms if it isn't caught early and treated with a specialized diet.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The peer support movement may date back to 18th century France

At the Bicêtre Hospital, an asylum near Paris, Jean-Baptiste Pussin (who had previously been a patient but later led the hospital administration) tried to hire as many staff as possible from among recovered patients. Chief physician Philippe Pinel found these individuals to be kinder than other staff and "averse from active cruelty" which was common at the time. This approach allowed the facility to move away from shackling patients and other violent methods.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

See a timeline of landmark discoveries in the field of genetics

From the first genetic map of fruit fly genes in 1911 through the completion of the Human Genome Project in 2003, scientists have built upon each other's discoveries to further our knowledge of the human body and the genetic instructions that inform our traits and disease risks.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.

Plastic's history began with an inventor seeking a $10,000 prize offer

In 1869, the first synthetic polymer—celluloid—was created as a substitute for ivory in billiard balls. It became the historical catalyst for the eventual manufacturing of plastics everywhere as an alternative to the depletion of other natural resources, including tortoiseshell and horns.

The frozen pizza was invented in 1950

In 1950, some pizzerias were premaking pies, allowing customers to take them home and cook them at their convenience. That same year, Philadelphia's Joseph Bucci filed a patent for a "Method of Making Frozen Pizza." Soon, frozen pizzas were appearing in grocery store aisles.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

Modern bodybuilding evolved in the 19th century

The origins of modern progressive resistance exercise are traced to ancient Greece, where a repeat Olympic victor carried a calf every day until it grew into a full-sized ox. This 56-minute comedy and history podcast journeys through the rise of modern bodybuilding, which took off during the 19th century.

The oldest medical report of a near-death experience dates to around 1740

In 2014, Dr. Philippe Charlier, a medical doctor and archeologist, found a French medical book from 1740 that described the near-death experience of a pharmacist. Using the Greyson Scale, Charlier found that the incident would have rated at least 12/32, more than high enough to scientifically classify as an NDE by today’s standards.

The first private equity fund was launched in 1960

At the time, the industry—and the public's understanding of it—was rather limited, and few private equity firms existed until the 1980s. The first leveraged buyout is thought to have taken place in 1955.

Computer scientists first started trying to optimize dating using computers in the 1950s

Although early dating sites like Match.com weren't launched until the 1990s, the history of dating apps dates arguably back to the mid-1900s when computer scientists used IBM computers to solve matchmaking and compatibility problems.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'