Penicillin production was just behind the atom bomb in wartime priorities

It took 14 years to deploy penicillin after its discovery

Despite its promise, US production of penicillin remained minimal in 1942—enough to treat fewer than 100 patients nationwide. Within two years, output expanded into millions of doses to supply troops for D-Day.

Penicillin supplies were ready for every wounded soldier on D-Day

By June 1944, Allied stockpiles included 2.3 million doses of penicillin—enough to ensure that every soldier wounded during the pivotal Normandy landings could receive treatment.

Penicillin slashed battlefield pneumonia deaths during World War II

Before antibiotics, bacterial pneumonia killed about 18% of infected soldiers in World War I. By World War II, penicillin cut that death rate to less than 1%.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Penicillin is considered one of history’s greatest medical breakthroughs

Experts widely rank penicillin’s discovery among the most important advances in medicine. It launched the antibiotic era, transformed once-deadly infections into treatable illnesses.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

Penicillin works by attacking the cell walls of bacteria

Penicillin targets bacteria at their weakest point—their cell walls. By blocking wall-building, it leaves microbes unable to survive, causing them to burst and die.

Building the first atomic bomb required unprecedented coordination

Creating the first atomic bombs demanded breakthroughs in physics, engineering, and logistics—uniting elite scientists with tens of thousands of workers across the US. This in-depth history explains how the Manhattan Project overcame those challenges.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

World War II helped convince food companies to produce more processed foods

Processed foods had existed since the 19th century, but they began infiltrating the mainstream during World War II, with foods designed to last on the battlefield for days. After the war, food companies saw great potential in the relatively cheap foods aimed at busy households. (Some readers may experience a paywall.)

US secrets: Project Paperclip

The US launched Project Paperclip in 1946, covertly recruiting over 1,500 German scientists to advance American military and space programs. Among them was Wernher von Braun, a key architect of the V-2 rocket who later became instrumental in NASA’s Apollo missions. While these scientists accelerated technological breakthroughs, their recruitment raised moral debates about overlooking wartime affiliations in the name of progress—questions that remain unresolved today.

Roughly 80% of US antibiotics sold each year go to agricultural use

Antibiotics have long been used in agriculture to treat diseases in animals and plants. However, antibiotics are also often misused, to treat non-bacterial diseases, to encourage growth in animals, and more. This expansive use of antibiotics has become one of the primary sources of the emergence of new superbugs.

Lyme disease-causing bacteria predate any suspected biological weapons testing

Borrelia bacteria existed long before any US biological weapons program—or human presence in North America. One study comparing genomes of the bacteria behind Lyme disease collected samples of the bacteria over three decades and calculated that the bacterium has been in North America longer than humans, at least 60,000 years. Other work found related bacteria preserved in amber from millions of years ago.

Japan had the world's best carrier aviation in 1941

In late 1941, Japan possessed the world’s most powerful carrier fleet and the best-trained naval aviators, giving it a short-term edge over the US. But Japan couldn’t replace ships or pilots quickly, and US industry would soon outbuild it.

2 months after Pearl Harbor, American libraries launched a drive to collect 10 million books for soldiers

The 1942 Victory Book Campaign—sponsored by the American Library Association, the Red Cross, and the USO—asked the public to donate books to both train and entertain troops. The national campaign exceeded its goal, collecting more than 10.2 million books.

See how global nuclear arsenals surged—then shrank—by country since 1945

Worldwide nuclear stockpiles peaked at over 60,000 warheads in the mid‑1980s during the US-Soviet arms race. Today, about nine nations collectively maintain roughly 12,000 warheads, with Russia and the US still holding the majority.

How nylon was created

Nylon, one of the most ubiquitous materials in the world, was invented in 1935. Chemist Wallace Carothers was hired by American conglomerate DuPont to perform research. After seven years of work he produced nylon, the first wholly synthetic fabric. Carothers’ life ended tragically, but his contributions revolutionized everything from military equipment to women’s fashion.

Biotech is trying to boost drug production efficiency—using chicken eggs

A company called Neion Bio is genetically engineering birds in a bid to produce medical compounds, a herculean task that scientists have struggled with for decades. The US FDA has approved only one chicken-derived drug in the past—an expensive treatment for a rare liver disorder. (Some users may encounter a paywall.)

Should the US have entered into World War I?

America entered World War I in 1917, but had remained neutral until that point. President Woodrow Wilson addressed Congress, further underlining the USA's neutrality. Eleven weeks later, he asked for a declaration of war. With attacks by German saboteurs on an American munitions depot, it seemed he had no choice. But did he? This article asks what might have happened if the US stayed out of WWI.

Peptide research dates back to the late 1800s

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Riveting artwork from the battlefields during World War I

During World War I, the United States government commissioned eight artists to accompany American Expeditionary Forces to Europe to sketch and document what they saw. Drawing tanks, soldiers, shattered villages, and even German prisoners of war, the artists preserved much of the war as a matter of historical record and to rally support back home.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Brian Wilson wrote the Beach Boys' 'Don't Worry Baby' for the Ronettes, but the legendary girl group rejected it.

See the most iconic photos from four decades of LIFE magazine

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.