Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

Aphantasia involves a lack of mental images—but doesn't affect behavior

The condition, generally known about for over a century, first received its name in 2015 by researcher Adam Zeman. An estimated 4% of people lack this ability to perceive mental images, and research suggests this deficiency does not have any practical impact on behavior.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

'Melancholia' was the ancient Greek term for depression

"Melancholia" in Hippocrates's time was derived from the Greek word for black bile. This term made sense in its context since the Greeks believed that depression stemmed from an improper balance of the four humors.

NDEs typically change people's outlooks drastically and can prompt depression

The phenomena are regularly categorized as hallucinations, but some specialists are interested in their psychological nuances. Many survivors report feeling less anxiety about death, though some surveys show the experiences can increase physiological sensitivities.

Key tips for helping the depressed—including listening without judgment

Major depressive disorder is a clinical diagnosis and is not a lifestyle choice. Those who struggle with depression can express persistent feelings that are difficult to process and make sense of for friends and family. This guide walks through some counterintuitive perspectives, including resisting the urge to force a depressed person to do the things that would make them feel better.

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

Anosmia is the total loss of the sense of smell

This type of loss—due to disease or trauma—has ripple effects, including an altered or limited sense of taste. This video details the anatomy and physiology of our sense of smell and taste and how these senses are interrelated.

Would you opt for a life with no pain?

Philosopher Robert Nozick famously posed a question challenging the philosophy of hedonism—the idea that maximizing pleasure is the greatest good in life. His thought experiment imagined people could plug into a machine that would give total pleasure, suggesting the idea itself is not a compelling or desirable one. Learn the arguments and ideas in this short video.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century'

The phobia's name is short for "no-mobile-phone phobia" and was first recognized as a result of 2010 UK government study that found men, in particular, were uncomfortable and anxious being away from their devices.

The neuroscience of REM atonia disorders, where patients act out dreams

What prevents the typical person from acting out their dreams? Temporary paralysis of skeletal muscles, usually leading up to, and during, REM sleep. This academic article and related graphics explore what happens when this process doesn't go as planned, leading to REM sleep behavior disorder.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

Grief is defined as the anguish and physiological distress experienced after significant loss

It usually occurs following the death of a loved one, and symptoms may include confusion, apprehension about the future, separation anxiety, and ruminating on the past.

Nostalgia is a psychological coping mechanism that can help combat loneliness—but it's created from bias

Researchers have observed that though nostalgia can help counteract feelings of loneliness, our memories of the past are somewhat rose colored. Negative emotions seem to fade faster than positive ones, a phenomenon that they suggest may be a psychological coping mechanism so that memories don't hurt every time they're recalled. (Some users may experience a paywall.)

When common sounds become disturbing

Misophonia causes certain sounds to feel violating, triggering a "very visceral kind of experience" filled with extremely unpleasant emotions, including annoyance, anger, and disgust. A 2017 study found that people with misophonia have elevated activity in the brain's anterior insula—a region associated with interoception, emotional processing, and behavioral responses—when exposed to trigger sounds. Ongoing research suggests trigger sound context affects the severity and manifestation of the condition.

Clinical burnout: prolonged exhaustion, mental distance, and persistent negative feelings

Burnout isn’t just stress—it’s a pervasive feeling of exhaustion that can start in the workplace and seep into everyday life. It causes feelings of dread and cynicism about work tasks. On top of emotional distress, there can be physical symptoms and a tendency towards addictive behavior.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Opioids mimic naturally produced endorphins to dull pain

Once in the body, opioids bind to naturally occurring opioid receptors typically used by endorphins to temper pain. They trigger the release of dopamine, a desire-related hormone, and decrease noradrenaline, a neurotransmitter involved in heart and breathing rate regulation, meaning high doses can slow these processes to dangerous levels.

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Some Ozempic users lose their desire to eat

This essay follows a writer whose Ozempic journey involves a dramatic loss of appetite, leading them to stop compulsive snacking and even lose some of the joy of eating. As a result, he becomes fixated on watching food videos and eventually tries to "beat" an all-you-can-eat steak buffet. The experience leaves him feeling disappointed and lacking in desire.

Menopause can exacerbate anxiety

Some research shows that menopause can fuel anxiety and also that pre-existing anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments including hormone replacement therapy, breathing exercises, and other forms of exercise can alleviate some of these symptoms.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Schizophrenia symptoms often appear suddenly

Schizophrenia is a particularly shocking mental illness because its symptoms may appear seemingly without any prior signs of illness after a person has had no symptoms for the first couple of decades of their life. Among teens, symptoms may look like typical adolescent behaviors—withdrawal, being irritable, and having trouble sleeping.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Muted smell and taste in microgravity complicate meal enjoyment

Astronauts primarily consume freeze-dried meals, which are rehydrated with water recycled from urine and perspiration, directly from bags. Condiments and select cultural items from crew members can enhance the meal experience by boosting flavor. Many individuals report experiencing "food fatigue" due to a lack of fresh produce, limited menu variety, and lingering scents.

Symptoms of DNA loss may mimic those seen in mushroom poisoning or chemotherapy

Although no organism has ever lost all its DNA, the destroying angel mushroom contains amatoxin, which disrupts DNA transcription and is known to cause death via liver and kidney failure in three days. Doxorubicin, which tangles DNA to disrupt cellular replication, compromises a person's immune system.

What it feels like to live with dementia

This nine-minute short film attempts to answer what it feels like to fade into dementia, as memory, motor skills, and cognition steadily decline. This award-winning short film follows Jos, a married father who worked in hospitality, as he sinks into ,"what feels like a single day. Or is it years?"

Explore an interactive map showing what makes people happy

Using 10,000 responses collected from people around the world about what makes them happy, this map offers insights into how relationships, finances, purpose, and small treats all contribute to a person's contentment. Recent data suggests that young people today are less happy than those in previous generations, indicating a need to reflect on what really matters in life.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

'Silent' fireworks have gained more interest in recent years as a quieter celebratory option.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

El Niño, Spanish for 'the boy,' was named after Jesus Christ because the phenomenon resembled the weather changes observed around Christmastime.

Apollo astronauts left items in the moon's 'toss zone,' including golf balls, family photos, and bags of human waste, to make room for lunar rocks.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'