The depression paradox refers to a lack of energy to take action to help alleviate it

Key tips for helping the depressed—including listening without judgment

Major depressive disorder is a clinical diagnosis and is not a lifestyle choice. Those who struggle with depression can express persistent feelings that are difficult to process and make sense of for friends and family. This guide walks through some counterintuitive perspectives, including resisting the urge to force a depressed person to do the things that would make them feel better.

Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

This common symptom—a flat affect—results in previously enjoyable hobbies no longer bringing pleasure. People with anhedonia may also avoid social situations because they anticipate they'll bring no joy, not because of anxiety or fear.

Depression is much more than sadness—and isn't fleeting

The American Psychiatric Association's DSM-5—used for defining diagnoses—says a person must be experiencing five or more symptoms of depression most of the day over at least two weeks. Research indicates older people are less likely than younger people to meet that depression benchmark, though this article says they still often have at least several of the depression symptoms.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients

There are three major categories of antidepressants—tricyclic antidepressants, monoamine oxidate inhibitors, and selective serotonin reuptake inhibitors. This podcast notes these first-line depression drugs are not effective for many patients and may also come with concerning side effects. Other therapeutic approaches—either in combination with medication or as an alternative—include therapy, meditation, and consistent exercise.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

Even brief physical activity can trigger the release of neurotransmitters that provide mental health boosts

A couple of minutes of light walking or stretching can increase feelings of energy and reduce fatigue, not just through the release of endorphins. Exercise can also provide self-regulation and improve task engagement and focus in those with certain mental health disorders, like ADHD.

Inflammation appears to cause specific symptoms of depression

A large analysis of existing studies published in 2021 found that systemic inflammation is associated with fatigue, appetite changes, and sleep disruption, rather than some of depression's broader symptoms including hopelessness about the future, or feeling fearful. This may suggest that inflammation influences specific symptoms of the condition, rather than the disease as a whole.

Forcing a smile can actually make you feel slightly better

Activating your smile muscles—in this case, with electrical muscle stimulation that forces the corners of the mouth upward—makes people feel more positive, according to recent research. It won't cure depression, but it can have a small effect. Earlier faux smile research using different nonelectrical techniques had similar results, collectively suggesting that a smile may help brighten your day—even though the mechanisms for the happier result remain unclear.

How to cope with postvacation blues

While it might seem counterintuitive, new research shows that experiencing exhaustion or a lack of motivation postvacation is fairly common. While travel itself can, of course, be tiring, the contrast between vacation freedom and endless Slack messages can be even more so. This article explores why the return-to-work existential crisis happens, and offers advice for beating the post-vaycay blues. Read it here.

Could this pseudo-psychedelic VR experience decrease symptoms of depression?

Researchers report that virtual reality and psychedelics may be leave users with similar insights and therapeutic benefits. Try out this free psychedelic virtual reality experience to see if this holds true for you. According to the program’s creators, a study into the efficacy of this 45-minute experience indicates it may help alleviate symptoms of mild to moderate depression.

Touch deprivation can heighten anxiety and depression

Pacinian Corpuscles are pressure receptors just under the skin that send signals to the vagus nerve in the brain—that's the cranial nerve which regulates involuntary actions like breathing, heart rate, and the general "fight or flight" response. Activating those receptors can slow the heart, decrease blood pressure, and lead to the release of oxytocin and cortisol. The absence of touch, conversely, can promote negative feelings.

Up to 400 milligrams of caffeine a day is considered safe

Small, frequent doses can be more effective than large amounts, though caffeine can raise blood pressure and heart rate, especially in people with hypertension. While low doses of caffeine may help with depression by stimulating dopamine, excessive caffeine, particularly from energy drinks, can lead to anxiety and heart issues.

Is metabolism related to weight loss?

Read this article to better understand metabolism and why doctors say it's only one piece in the puzzle to managing weight. Metabolism breaks down and converts what we consume into energy, which provides fuel for all of our body's functions—both...

The neuroscience of REM atonia disorders, where patients act out dreams

What prevents the typical person from acting out their dreams? Temporary paralysis of skeletal muscles, usually leading up to, and during, REM sleep. This academic article and related graphics explore what happens when this process doesn't go as planned, leading to REM sleep behavior disorder.

Muscles fatigue due to the loss of energy like ATP and glycogen

Adenosine triphosphate fuels muscle contraction, and with each contraction (like during exercise), the amount of ATP reduces. ATP helps potassium and sodium move across muscle membranes, generating ions and helping to contract the muscle.

Some Ozempic users lose their desire to eat

This essay follows a writer whose Ozempic journey involves a dramatic loss of appetite, leading them to stop compulsive snacking and even lose some of the joy of eating. As a result, he becomes fixated on watching food videos and eventually tries to "beat" an all-you-can-eat steak buffet. The experience leaves him feeling disappointed and lacking in desire.

Volunteering can alleviate the feeling of loneliness

The Freakonomics team explored loneliness in this 2020 podcast episode and discussed how volunteering can be a powerful way to make lonely individuals feel needed, like they have a purpose, and combat feelings of isolation.

The myth of sugar rushes vs. the reality of sugar crashes

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

The psychological aspect of deflation makes it difficult for policymakers to stabilize the economy

That psychological aspect is referred to as "the deflationary spiral." When prices start decreasing, people tend to hold on to their money to pay the lowest prices. But as prices start stabilizing, people resist increasing prices. (Some users may experience a paywall.)

10 percent of SAD cases occur in the summer

Despite its significantly lower incidence, summer-risk SAD is as significant as its winter counterpart. Rather than being prompted by less light, the summer version is typically spurred by high temperatures, strong light, distinct summer time social pressures (appearing in a bathing suit, for example), and pollen. Common treatments include keeping cool and prioritizing sleep.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Estimates suggest inactivity contributes to 6% of deaths worldwide

The World Health Organization identifies physical inactivity as the fourth leading modifiable risk factor for global mortality, just behind hypertension, tobacco use, and high blood glucose. Latest estimates are that inactivity contributes to 6% of deaths and significantly increases the burden of chronic diseases like heart disease, diabetes, and cancer.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The business model for many dating apps is paradoxical

While these apps are designed to help people create romantic relationships, dating apps lose money when people find a monogamous relationship and stop using the app as a result. Some call it the dating app paradox.

Catalysts increase chemical reaction rates by providing a lower energy pathway

All chemical reactions must overcome an energy barrier, called an activation energy, to proceed. If insufficient thermal energy exists in the system to overcome the barrier, catalysts can effectively lower the activation energy, increasing the likelihood of reactions occurring.

The discovery of antimatter came from addressing a prediction of negative energy

Combining the mathematics of quantum mechanics and special relativity, Paul Dirac came up with an equation that suggested a matter particle, such as an electron, could exist in four quantum states—two of which possessed negative energy. The solution came from realizing that the states referred to positive-energy antiparticles, whose charge is the opposite of that of their normal-matter equivalent.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

The Ramones' 'Pet Sematary,' the theme song for the Stephen King novel of the same name, was written while the band was admiring the writer's collection of horror memorabilia.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Hurricanes, which rely on air consistently spinning in the same direction, cannot cross the equator because air curves in opposite directions north and south of it.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.