Muscles fatigue due to the loss of energy like ATP and glycogen

Why death is caused by a dearth of ATP

Though people die from many causes, this video makes the case that a lack of adenosine triphosphate production in the body is what kills almost all of us. Without ATP, physiological processes grind to a halt, and organs stop functioning.

Microtears in muscles from exercise cause fibers to grow back larger

Placing muscle under increased load or stress causes damage that requires rest to repair, leading to stronger, more enduring muscle over time. Muscles adapt to such increasing demands by improving their efficiency with approaches that include increasing the number of mitochondria housed in hundreds of thousands of muscle cells.

One of the leading theories behind muscle movement

According to the Sliding Filament Theory, skeletal muscle contraction is made possible by sarcomeres, which are made of bundles of myosin and actin proteins inside muscle cells. Myosin pulls itself along actin to contract a muscle, shortening the muscle and its cells and enabling physical movement. It then releases its grasp on actin so it can start the process over again if so commanded.

Myokines are molecules that facilitate some of the benefits of exercise

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

How does your body turn food into energy?

Cells get energy via a process known as cellular respiration, which involves turning glucose into ATP or adenosine triphosphate. Breaking the phosphate bonds of ATP results in usable energy being released into cells, which can then use that energy to power biological processes. This 10-minute video explains how glucose turns into ATP, giving the body the energy it needs to survive.

Coffee gives you energy, but it ultimately makes you more tired

The caffeine in coffee delays your brain's fatigue signals. Caffeine blocks adenosine, a compound that builds up as you burn energy and signals rest. Once caffeine wears off, adenosine floods back, leaving you even more tired.

Adults may lose roughly 3% of their muscle mass each decade after 30

That muscle loss, formally referred to as sarcopenia [saar-ko-pee-nee-uh], averages 3% to 5%, depending on physical activity. These losses can progress with age, but resistance training helps combat some of this natural degradation.

How ALS (Lou Gehrig’s Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Microgravity environments reduce muscle mass and bone density

Muscles that assist with balance and resistance to gravity are not subjected to their usual workload on the International Space Station. See the type of exercises that astronauts must complete for roughly two hours daily and learn why these movements are necessary to preserve astronauts' muscles, bones, and cardiovascular health.

VO2 max measures the body's ability to use oxygen to produce energy

VO2 max is the maximum rate at which the body can use oxygen to aerobically produce energy—adenosine triphosphate—for use during intense exercise. Aerobic exercise increases VO2 max, counteracting age-related decline by increasing the body's capillary count and remodeling the heart's left ventricle, increasing the amount of blood it pumps.

The stages of fasting

What happens to the body when it goes without caloric intake? This article overviews the immediate physical effects of fasting. Within a day of going without food, the body will have used up its glucose stores and ordered the liver and muscles to convert their glycogen (glucose storage) into usable glucose. By the second day, glycogen stores will run out, forcing the body to use fat as energy. This process is known as ketosis.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

Aging explained with Dr. Nick Golinvaux

Aging is more than wrinkles and gray hair—it’s a gradual decline in cellular function. Over time, DNA damage, telomere shortening, and mitochondrial inefficiency contribute to weaker bones, slower memory, and reduced vitality. While aging is inevitable, regular exercise, quality sleep, and stress management maintain health and extend one’s years.

Stress-induced adrenaline can trigger a 'hysterical strength' response

The stress response is a powerful ancient mechanism designed to maximize human survival—it can even result in superhuman strength. The adrenal glands are located just above the kidneys, and stress-induced adrenaline release causes more blood (and therefore more oxygen) to flow to your muscles, increasing performance.

Exertional heatstroke is a top killer of athletes and soldiers-in-training

Often characterized by collapsing while exercising in the heat with intense sweating, this type of heatstroke among otherwise healthy people occurs when the body loses the ability to cool itself during intense exercise and the body's core temperature has risen to 104 degrees Fahrenheit or higher and cannot cool itself. If treated quickly, it's often survivable, though it can cause lasting damage.

How muscles get their names

There are more than 600 muscles that crisscross the human body, and each has a name that's more than a simple label. Muscle names also typically communicate the muscle's size, behavior, length, location, appearance, direction, and attachments to bone. These names usually have Greek or Latin roots, such as in the case of the deltoid muscles, which are named in reference to the Greek letter delta (𐤃).

Endurance art strains and exhausts the body

Artists like Marina Abramović are known for testing the limits of human endurance. Endurance art can involve carrying heavy objects or posing uncomfortably for long durations. (This resource contains some artistic depictions of violence.)

Gradual chemical build-up reduces the effectiveness of rechargeable batteries

During charge cycles, small chemical deposits gradually form a film on the electrodes where they make contact with the electrolyte, trapping ions that would otherwise facilitate the flow of electricity. Mechanical degradation from electrode wear and electrical shorting from structural instability can also reduce battery capacity.

Runners typically burn 2,600 calories during a marathon

They also burn between 5-10 pounds of water weight, often feel more focused and elated (thanks to increased neurotransmitters), and, oddly enough, temporarily grow about a half-inch shorter due to back muscles tensing.

Explore the abundance of different types of cells in the human body

Lacking a nucleus and other organelles to maximize space for oxygen-carrying hemoglobin and enhance maneuverability through narrow capillaries, there are about four times as many red blood cells and platelets as all other cell types in the body combined. However, about half of the body's cell biomass consists of skeletal myocytes, or muscle fibers.

Olympians view sleep as a performance tool, prioritizing routine and environment

Elite athletes emphasize consistent sleep routines, dark and cool environments, the well-placed nap, and tools like eye masks, white noise machines, and supplements like melatonin (particularly for jet lag). This priority belies a core principle: recovery and performance are inseparable. Read more ways Olympians "sleepmaxx" here.

Drug tolerance and withdrawals are consequences of overloading dopamine circuits

Addictive substances or behaviors will typically flood our brains with more dopamine than usual. In response to the overstimulation, our brains will decrease the number of available dopamine receptors. This results in the need for more stimulus for the same response (tolerance) and a rise in negative feelings when the stimulus is absent (withdrawal).

Bath bombs can produce endothermic reactions that cool water

In bath bombs containing citric acid and sodium bicarbonate, water facilitates the reaction between the bicarbonate and acid, providing energy as the salt dissolves. The loss of energy in the water reduces the average speed of the water molecules, reducing the temperature of the bath.

Gatorade was first designed for college football players in Florida heat

To help replenish crucial chemicals football players were losing fast to their profuse sweat in southern heat, researchers at the University of Florida developed a drink blended with salts and sugars that were easy to absorb. The drink, Gatorade, took its name from the school's mascot.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Tattoos remain visible on your skin thanks to immune cells called macrophages

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.