Aging explained with Dr. Nick Golinvaux

Aging is a complex biological process affecting our cells, tissues, and organs

With each passing decade, researchers uncover additional causes and effects of this seemingly unstoppable process. This visually stimulating video dives into our current understanding of aging, complete with the biological hallmarks researchers use to study aging at the cellular level (biological age).

DNA damage and chemical stress causes cellular aging

While outward signs of aging, like gray hair and wrinkles, are easy to spot, aging changes at the cellular level are less obvious. The decline within cells stems from numerous sources, including DNA damage, oxidative stress, and accumulated waste.

Arthritis explained, with Dr. Nick Golinvaux

Arthritis, a condition affecting millions globally, is more than just joint pain—it’s a breakdown of cartilage that cushions bones, leading to stiffness, swelling, and discomfort. While often associated with aging, arthritis can affect people of all ages, especially after injuries. Though there’s no cure yet, treatments range from medication and physical therapy to surgical interventions like joint replacements.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

Doctors use three key physical markers to determine biological aging

The length of the ends of chromosomes (known as "telomeres"), the gradual change in collections of DNA molecules called "methyl groups", and the secretion of inflammatory proteins are all used as indicators of biological age.

The formula behind super agers—those possessing health and cognitive skills of people decades younger

A study of about 1,400 super agers did not identify any underlying genetic mechanism for longevity. While researchers instead emphasized that sustainable habits involving positive social connections, sleep, mood, diet, exercise, and personal fulfillment help reduce long-term risks, there is no one-size-fits-all formula for everyone.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Inflammaging is chronic low-level inflammation as we age, and it may be a key disease driver

The term refers to the idea that largely invisible but consistent low-level inflammation as humans age fuels chronic diseases and cellular aging. Inflammaging, this article says, is due to lifestyle factors like poor sleep, low levels of activity, and poor diet, acting in concert to cause cellular damage and trigger inflammation.

Ten writers and thinkers on what growing older actually requires of us

The Marginalian's Maria Popova curates a collection arguing our culture has learned to dread aging while forgetting it is a privilege, and that the antidote is sustaining passions strong enough to keep us from turning inward. Voices include Simone de Beauvoir, Joan Didion, Pablo Casals, and Kahlil Gibran.

External factors, not aging itself, lead to sleep loss in older adults

Though it is often believed that people need less sleep as they age, the recommended sleep guidelines for all adult age groups are almost identical. However, factors such as medication use, lack of physical activity, and loneliness can lead to sleep problems, and thereby lead older people to believe that they actually need less sleep than they do.

Perceived isolation ages you

Mounting evidence suggests that socialization is a vital component of maintaining good health. Research published in 2024 from Mayo Clinic researchers analyzed the social lives of more than 280,000 adults and concluded that individuals that weren't likely to participate in extracurricular social activities and get-togethers were more likely to have a biological age older than their actual age—meaning that you may be 60 but health indicators would suggest you're older.

Do people really look younger than they used to?

Why do people today look younger than they used to? From style to science, there are 3 surprising reasons we age differently now.

Adults may lose roughly 3% of their muscle mass each decade after 30

That muscle loss, formally referred to as sarcopenia [saar-ko-pee-nee-uh], averages 3% to 5%, depending on physical activity. These losses can progress with age, but resistance training helps combat some of this natural degradation.

Exercise changes your genes without changing your DNA

Physical activity can turn beneficial genes on and harmful genes off, without altering the underlying DNA code. This engaging article explains the epigenetic mechanisms that take place with exercise and ultimately result in improved metabolism, lower inflammation, and optimized brain function.

'Old people' smell is real—it's a chemical buildup when fatty acids on the skin oxidize

The chemical composition of body odor seems to change with age. Later in life, we harbor higher concentrations of a chemical compound called 2-nonenal that forms when omega-7 fatty acids on the skin oxidize, and the skin's natural antioxidant defenses weaken. Commonly called "nonenal", it's the smell widely associated with aging, and it's often described as a grassy or greasy odor.

How family members disappeared into dementia

This narrative feature describes one family's troubling experience with frontotemporal dementia, or FTD, which emerges in the prime of adult life — as young as 40, in some cases — and degrades the brain's ability to plan, organize, express language, understand social cues, and exercise judgment.

What do vitamins actually do?

Vitamins are molecular tools the body needs to carry out regular cellular processes, such as wound healing. This 45-minute video dives into the science behind vitamins and their role in the body. There are 13 essential vitamins that must be...

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Learn the differences between mild cognitive impairment and age-associated memory loss

Mild cognitive impairment is a condition in which people experience more thinking and memory problems than expected for their age. It's often associated with depression and anxiety. Daily routines, writing things down, and healthy lifestyle choices can help cope with the condition, but there's no cure. The condition elevates the risk of developing dementia and Alzheimer's.

A sleep expert discusses the broad benefits of quality rest

In this three-part series, renowned sleep expert Matthew Walker and doctor Peter Attia explore the role of sleep in memory consolidation and mental health, and the detrimental effects of chronic lack of sleep. The latter has been linked to increased risk of dementia, hypertension, and more.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Too little stress can be as problematic as too much stress

Hormesis—mild or moderate stress followed by recovery—helps make us more resilient. A stress expert speaking during this roughly 30-minute CNN special explains that our bodies depend on periodic mental and physical challenges to activate our innate defense mechanisms, spurring cellular repair and regeneration.

Why death is caused by a dearth of ATP

Though people die from many causes, this video makes the case that a lack of adenosine triphosphate production in the body is what kills almost all of us. Without ATP, physiological processes grind to a halt, and organs stop functioning.

How meal timing factors into health outcomes

The world is trending toward weight gain, a development that comes with a corresponding rise in risk for health conditions, including diabetes and heart disease. This article explores how meal timing has become a factor in nutrition and weight maintenance.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Dr. Bruce Greyson on what we know, and how to study, near-death experiences

Considered one of the premier researchers on near-death studies, Dr. Bruce Greyson discusses what researchers know (and don't know) about what happens as we near death, and recounts his decades of observations on the phenomenon.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

Poison ivy will likely become both larger and more resilient due to climate change.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.