The neuroscience of REM atonia disorders, where patients act out dreams

Dreams largely occur during REM sleep (but not entirely)

Modern imaging tools have enabled scientists to carry out in-depth studies of brain activity during sleep. Researchers know dreams arise largely during REM, blending emotion-driven visual imagery, memory consolidation, and weak associations to help us make sense of experiences, regulate emotions, and prepare for future situations.

Why do dreamers twitch?

This thought-provoking piece highlights newer research suggesting sleep twitches may not be random dream leftovers, but instead a crucial way our brains map and understand our bodies. From sleeping rat pups to dreaming octopi, this biological mapping system appears universal across animal species.

The REM cycle happens around four to six times per night

Sleep is a natural process that is critical to maintaining life—a process conserved throughout evolution across just about any animal with a brain. Generally speaking, the first three stages involve increasingly deep phases of non-REM sleep, followed by a roughly 90-minute period of REM sleep that repeats throughout the night.

Gibberish, urine, and utter chaos: what happens when you sleepwalk

Sleepwalking, or somnambulism, occurs most frequently in children who are in the deepest stages of sleep. REM, the sleep stage in which most people dream, often causes temporary muscle paralysis, so it’s only when sleepers pass to the deeper stages of sleep that sleepwalking—and sleep talking—can occur.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Sleep paralysis occurs when the body fails to 'unfreeze' in sync with waking

When the body falls into a deep enough phase of sleep, it paralyzes certain parts of itself so the brain can't force it to physically act out dreams. This well-known but little-understood phenomenon happens when the brain awakens early and typically results in haunting hallucinations and reports of supernatural terrors.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle

Narcolepsy not only makes people fall asleep at random moments, but it can also cause hallucinations, insomnia, and sleep paralysis. The disorder is tied to cells in the brain’s hypothalamus called hypocretin, which are neuropeptides responsible for keeping you awake and controlling your dreaming from coming on too quickly.

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

In 2011, a mysterious illness spread around LeRoy, New York

A handful of girls were stricken with bizarre twitches, tics, and spasms — all apparently involuntary. Some believed the incident to be conversion disorder, an illness where emotional troubles have physical symptoms.

Anesthetics slow brain activity by promoting inhibitory neurotransmitters

Drugs like propofol and isoflurane increase activity at the GABA receptor, which opens chloride channels. These ions enter neurons and hyperpolarize them, making them less likely to fire. Dexmedetomidine instead blocks norepinephrine receptors in the brainstem to sedate patients.

Nightmares are unpredictable, but are linked to stress, anxiety, trauma, and more

Nightmare comes from the terms "night" and "mare," an Old English word for evil, suffocating spirits. Nightmares are parasomnias, meaning they are undesirable events experienced during sleep, and may stem from building tensions in one's unconscious.

Deep brain stimulation helps manage movement in patients with neurological disorders

DBS is a surgical procedure that uses implanted electrodes to send electrical signals to targeted areas in the brain, interrupting abnormal neural activity. It may be implemented when medications lose effectiveness or cause disruptive side effects.

How ALS (Lou Gehrig’s Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

How the feared self fuels OCD

Obsessive-compulsive disorder is characterized by intrusive thoughts that prompt people to enact compulsions—behaviors intended to relieve the anxiety or stress from the obsession. A significant intrusive thought OCD sufferers endure is the fear they will become a dangerous or immoral person. Therapeutic approaches try to show patients this is just a story that can be set aside.

Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

This common symptom—a flat affect—results in previously enjoyable hobbies no longer bringing pleasure. People with anhedonia may also avoid social situations because they anticipate they'll bring no joy, not because of anxiety or fear.

How to end bedtime procrastination

Finally done with external obligations, you might plop onto the sofa and dive into a hobby or bit of media, pushing past sleepiness to have some time to yourself and enjoy doing what you want. This is known as "revenge bedtime procrastination," a behavior that feels relaxing but impairs sleep hygiene.

Memory disorders disrupt the brain's ability to make, store, or recall memories

These disorders stem from reversible issues like vitamin deficiencies or irreversible causes such as stroke or dementia. Only one type of dementia—familial Alzheimer’s disease—is directly inherited and accounts for about 20% of Alzheimer’s cases.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Studying involuntary, rapid eye movements is a key part of vertigo diagnosis

A doctor will look at a vertigo patient's rapid, uncontrollable eye movements—formally called nystagmus—to better understand its causes. When a patient is lying down with their head turned and their eyes spin in a certain position and stop it's likely a peripheral cause, but if the spinning doesn't stop or it changes direction it's more likely a central nervous system issue.

The Lazarus Effect is when a heart begins beating on its own after declared death

Formally called autoresuscitation, this rare phenomenon occurs when someone is declared dead following a cardiac arrest but their heart beats again without help—making it seem like the person came back to life. Doctors don't know the exact cause.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

One theory claims the retinae of SAD patients may fail to adjust to less light in winter

Most people’s eyes become more sensitive to light in the winter months, but some do not. This failure to adjust causes ripple effects on those individuals’ biological clocks. This Ted-ED video provides a clear, brief, narrative explanation of the condition in six minutes.

What (and why) is ASMR?

ASMR podcasts and videos are appearing all over social media, so what exactly is it, and what does it do? This immersive article explains the phenomena of ASMR, which stands for autonomous sensory meridian response. ASMR is when certain sounds or...

Muscular system explained

Skeletal, cardiac, and smooth muscles form the system that powers movement, survival, and daily life. Skeletal muscles are voluntary, enabling conscious actions like lifting or walking, while cardiac and smooth muscles are involuntary, controlled by the autonomic nervous system. From every heartbeat to each breath, these three muscle types work in harmony to keep you moving, thriving, and alive.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Explore the known asteroids, comets, and spacecraft involved in asteroid studies within our solar system with 'Eyes on Asteroids,' a 3D visualization from NASA.

Brian Wilson wrote the Beach Boys' 'Don't Worry Baby' for the Ronettes, but the legendary girl group rejected it.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

See this overview of the firework rules across all 50 states, ranging from a complete ban on non-professional fireworks in Massachusetts to states with more lax rules like Indiana.