What it's like to live with insomnia

A quick technical overview of insomnia

Insomnia is one of the world's most common sleep disorders. Characterized by difficulties falling and staying asleep, long-term struggles with insomnia can prelude or contribute to health difficulties. Treatments range from sleep hygiene management and relaxation therapy, and medication, including antidepressants and melatonin.

What sleep is for and why you can’t live without it

Sleep is one of the most important needs that humans have. The body uses sleep as a time of restoration and rejuvenation, as body tissues repair themselves, growth hormones are released, and the process continues. Brain plasticity theorists believe that sleep is also used for the processing and consolidating of new memories.

Studies suggest when you sleep is as important as how much you get

"Molecular clocks" made of timekeeping proteins and genes help regulate the body and its processes, meaning the disruption of one cog will impact another. Those who live in sync with their circadian rhythms report less fatigue, clearer thoughts, greater medication benefits, and better long-term health outcomes.

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The deadly genetic disease that steals shut-eye

Few are haunted by fatal familial insomnia. This neurodegenerative disease is typically carried through bloodlines via genetic mutation of the prion protein gene, forcing the body to create abnormal and pathological protein variations that can corrupt normal versions. This article follows a musician as they attempt to come to terms with the FFI plaguing their family (and, possibly, their future).

The brain will attempt to rest itself in periods of chronic sleep deprivation

Skimping on sleep lengthens reaction times and blunts decision-making skills. At a certain point, the brain will try to sneak sleep where it can, shifting sections offline even as you remain awake. Going without sleep raises blood pressure, undermines the immune system, and increases one's risk of dementia.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle

Narcolepsy not only makes people fall asleep at random moments, but it can also cause hallucinations, insomnia, and sleep paralysis. The disorder is tied to cells in the brain’s hypothalamus called hypocretin, which are neuropeptides responsible for keeping you awake and controlling your dreaming from coming on too quickly.

Poor sleep increases the risk of developing Alzheimer's

Brain imaging studies reveal poor sleep leads to production of amyloid beta proteins—molecules linked to Alzheimer’s—which are cleaned from the brain during high-quality sleep. These findings suggest conditions like sleep apnea and insomnia increase the risk of developing the disease.

Light pollution is giving oysters insomnia

Oysters, bivalve mollusks that have light-detecting cells along their skin, can't sleep with all this artificial light. According to a 2022 study, oysters' sleep cycles are disturbed by light dimmer than that provided by the full moon. As with humans, it's possible that these bouts of insomnia could have adverse health effects and contribute to the development of disease over time.

The US loses roughly $400B a year in productivity due to sleep deprivation

For an article about a woman who built a business empire telling bedtime stories, the Hustle created this graphic showing the estimated GDP loss associated with chronic insomnia. The United States had a much more significant loss than other countries.

A deeper walk through of the four stages of sleep

In this TED video, sleep expert Matthew Walker carefully breaks down the sleep stages along with a description of why each is important. He finishes the discussion by examining the consequences of altered or decreased sleep, and why seemingly small alterations in our sleep patterns can have outsized effects.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

What it feels like to live with dementia

This nine-minute short film attempts to answer what it feels like to fade into dementia, as memory, motor skills, and cognition steadily decline. This award-winning short film follows Jos, a married father who worked in hospitality, as he sinks into ,"what feels like a single day. Or is it years?"

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

How one autoimmune disease patient is questing for inflammation cures

This article's writer, who has Hashimoto's Disease and characteristic symptoms from her body attacking her thyroid—like exhaustion, hair loss, and brain fog—shares big take-aways from an anti-inflammatory retreat in Italy. The writer suggests that a holistic approach to eating, sleeping, and stress management, are the only sustainable ways to lower inflammation.

Shakespeare’s storytelling uses intricate, intertwining narratives

According to one professor, readers return to Shakespeare’s plays, not for his storylines, but to learn how things unfold. In the process, they often use his plays to understand why humans act the way they do.

This is what happens inside your body when you're sick

This video details the biology of what happens inside the human body during illness.

Dangers of a record-breaking, sleep-skipping stunt

In 1963, 17-year-old Randy Gardner decided to stay awake for as long as it took to break the current world record. He managed to stay awake for 11 days. In 2017, the then-71-year-old Gardner told NPR that his experience had come back to haunt him as insomnia. The challenge has since been removed from the Guinness Book of World Records due to its dangerous consequences.

'Those who dream by day are cognizant of many things which escape those who dream only by night.'

- Edgar Allan Poe (1809-1849) in "Elenora"

Hear what it's like to have malaria

In Kenya, as one malaria-sufferer explains, the disease is common enough that anytime a child has a fever or any sort of sickness families and the community will wonder if it's malaria. Sleeping under a mosquito net is recommended. Unfortunately, a gin and tonic will not keep malaria at bay.

During the first Biosphere 2 mission, crew members lost 16% of their body weight

Food and oxygen shortages drove the “Biospherians” to split into two factions—one seeking to bring in outside resources and another aiming to maintain isolation for the experiment’s integrity. Psychological stress was exacerbated further by the increasing prevalence of insect pests.

Schizophrenia literally means 'split mind'—a reference to patients' break with reality

Contrary to the name, patients do not have multiple personalities. Rather, the split mind refers to the sufferers' inability to distinguish reality from hallucinations when they are aware and awake. Cognitive difficulties, including challenges focusing and communicating are also common among those with schizophrenia, as well as auditory and visual hallucinations.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

What is it like to be a bee?

Scientists have long known the intimate features of bee anatomy: six limbs, five eyes, lots of hair, a long, tasteless tube -like tongue, and wings that stroke close to 12,000 times a minute. But getting inside the mind or consciousness of a...

Friedrich Nietzsche theorized that we will live our lives over and over again: the myth of eternal recurrence

Rather than a theory of physics, the idea is designed as a moral argument. While Nietzsche famously eschewed the Christian afterlife, he wanted to avoid the nihilism that results from no longer having such an ultimate horizon. In a mystical moment, the philosopher came to believe that the fleeting moments of our lives would be repeated, presenting a test: would you want to relive this moment? If not, he would argue, you're not living well.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Browse a detailed visual analysis of over 200,000 similes—comparisons that often use 'like' or 'as'—from popular fiction to see how frequently writers the same idiomatic expressions.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

Mark Twain spent decades feuding with the US Postal Service, convinced its costs and regulations were bureaucratic overreach.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.