The deadly genetic disease that steals shut-eye

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

How family members disappeared into dementia

This narrative feature describes one family's troubling experience with frontotemporal dementia, or FTD, which emerges in the prime of adult life — as young as 40, in some cases — and degrades the brain's ability to plan, organize, express language, understand social cues, and exercise judgment.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle

Narcolepsy not only makes people fall asleep at random moments, but it can also cause hallucinations, insomnia, and sleep paralysis. The disorder is tied to cells in the brain’s hypothalamus called hypocretin, which are neuropeptides responsible for keeping you awake and controlling your dreaming from coming on too quickly.

Sleep deprivation leads to buildup of danger molecules in the gut

Fruit flies genetically engineered to be awake for as long as they live tend to live half as long as their well-rested brethren. Analysis shows these modified flies suffer from a buildup of DNA-destroying reactive oxygen species in their guts. When enabled to sleep, the flies live as long as their counterparts.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

Here’s how different genetic disorders get passed on

The human genome is complex, as identified by the Human Genome Project. This article digs in to genetic disorders, the most common ones, and how they are diagnosed.

How Alzheimer’s disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer’s here.

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Genetic engineering mice is one idea to reduce Lyme disease transmission

Wild white-footed mice are the main carriers of Lyme. A research team is hoping to genetically engineer mice, using CRISPR, to make the animals immune to Lyme. They're proposing a field trial where they would insert a gene with an antibody to Lyme infection to break the disease transmission cycle on a private island and then try it in Nantucket if that goes well. Simply killing the mice isn't an option because it would upend food webs. Unlike traditional vaccines, this "heritable immunization" would pass from one generation of mice to the next.

Bill Nye did not have children for fear of passing on ataxia

In his 2017 documentary, Nye revealed the congenital, neurological condition on his father's side of the family, which is characterized by a lack of balance and problems with fine motor movement. He has since learned he likely does not have the disease, though both his siblings have shown symptoms.

Usher Syndrome, a rare genetic disorder, causes progressive hearing and vision loss

People with one of the subtypes of this condition have a genetic mutation that starves cells in the inner ear and the retina of proteins required for detecting sound and light. Gene therapy in animals has seemed like a promising treatment for the condition.

The evolution of dream science—from interpretation to advanced brain imaging

In the mid-1900s, dream scientists would tape study participants' eyes open, wait for them to fall asleep, and attempt to influence their dreams by shaking, tickling, and more. Now, advanced techniques like MRIs have shed new light on what’s happening in the brain as we sleep.

In 2011, a mysterious illness spread around LeRoy, New York

A handful of girls were stricken with bizarre twitches, tics, and spasms — all apparently involuntary. Some believed the incident to be conversion disorder, an illness where emotional troubles have physical symptoms.

Watch Cordyceps, a parasitic fungus, turn an ant into a ‘zombie’

This National Geographic TV clip shows how a parasitic Cordyceps species—sometimes colloquially called the “zombie ant fungus”—controls an ant’s behavior and kills its host. The fungus can rapidly wipe out entire insect colonies.

A family's yearslong poisoning

Over 14 years, a southern Indian family slowly lost six members, several of whom were found foaming at their mouths. Upon the third death, a post-mortem examination was requested, revealing cyanide had been ingested, though it was ruled as self-inflicted. Several will edits and three deaths later, relatives turned a critical eye toward Joliyamma "Jolly" Joseph, who had married into the family and been present at each death.

Why one Emily Dickinson biographer believed she had epilepsy

Lyndall Gordon's "Lives Like Loaded Guns" points to a "handicap" referenced in several Dickinson poems. According to Gordon, the condition was so stigmatized during Dickinson's life that it made her reclusive. In this NPR interview, Gordon explains why she believes the theory is the best explanation for Dickinson's notorious isolation.

Inflammaging is chronic low-level inflammation as we age, and it may be a key disease driver

The term refers to the idea that largely invisible but consistent low-level inflammation as humans age fuels chronic diseases and cellular aging. Inflammaging, this article says, is due to lifestyle factors like poor sleep, low levels of activity, and poor diet, acting in concert to cause cellular damage and trigger inflammation.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

'Sloth fever' is an emerging health threat, especially to pregnant women

This disease, caused by the Oropouche virus, is found in animals including sloths, primates, and birds. It primarily spreads through the bite of midges—insects commonly called "no-see-ums." It's endemic to the Amazon region, but US travelers are increasingly contracting it internationally.

O’Connor’s mother insisted her daughter’s corpse smile

At 39, Flannery O’Connor died from lupus. Sally Fitzgerald privately recounted that Regina O’Connor asked a mortician to have the deceased Flannery’s face be fixed in a smile “with the teeth showing.” Ironically, it was a detail that would’ve been at home in one of her daughter’s stories.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The story of serial killer Ed Gein who inspired pop culture

The creators of antagonists from "Silence of the Lambs" and "Texas Chainsaw Massacre" took notes from this horrifying Wisconsinite's story, known for body-snatching and creating keepsakes from corpses.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The science of fear

The Hidden Brain podcast team explores the science of fear by traveling to a haunted house curated by a scientist to investigate what scares us, and why some people enjoy this sensation more than others.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

The Ramones' 'Pet Sematary,' the theme song for the Stephen King novel of the same name, was written while the band was admiring the writer's collection of horror memorabilia.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The idea for the Federal Reserve was conceived in secret in 1910—with bankers donning duck hunt gear for disguise while traveling to a remote country club on Georgia's Jekyll Island