She can't feel pain, hunger, or danger

The deadly genetic disease that steals shut-eye

Few are haunted by fatal familial insomnia. This neurodegenerative disease is typically carried through bloodlines via genetic mutation of the prion protein gene, forcing the body to create abnormal and pathological protein variations that can corrupt normal versions. This article follows a musician as they attempt to come to terms with the FFI plaguing their family (and, possibly, their future).

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

Would you opt for a life with no pain?

Philosopher Robert Nozick famously posed a question challenging the philosophy of hedonism—the idea that maximizing pleasure is the greatest good in life. His thought experiment imagined people could plug into a machine that would give total pleasure, suggesting the idea itself is not a compelling or desirable one. Learn the arguments and ideas in this short video.

Tetrachromacy allows humans to observe 10 times the normal amount of colors

Resulting from a mutation on the X chromosome, the rare genetic condition causes individuals to possess an additional type of photoreceptor cell, typically sensitive to the orange range, located between the standard red and green cones. This enables the perception of approximately 100 million colors.

The ultrarare 'Er' blood type has been documented only about 40 times

In 2022, the tragic loss of a pregnancy led researchers to the discovery that the rare "Er" blood type could potentially cause a mismatch in blood types between mother and fetus during pregnancy, with devastating consequences. (Some users may encounter a paywall.)

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Which organs can you live without?

While there are some organs (such as the heart) that people simply can’t live without, there are other organs that can be removed without a huge impact. Patients who have their appendix removed, for example, experience no changes to their daily...

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

Hereditary hyperosmia is the official term for being a super-smeller

Some sniffers with this rare trait may be more sensitive to pleasant smells, while others may be more attuned to unpleasant scents. Some research suggests that certain genetic mutations are associated with a heightened sense of smell.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone

19.2M Americans suffer from phobias, including extreme fears of spiders, snakes, heights, and flying.

Why one Emily Dickinson biographer believed she had epilepsy

Lyndall Gordon's "Lives Like Loaded Guns" points to a "handicap" referenced in several Dickinson poems. According to Gordon, the condition was so stigmatized during Dickinson's life that it made her reclusive. In this NPR interview, Gordon explains why she believes the theory is the best explanation for Dickinson's notorious isolation.

Six-year-old boy in wheelchair surprises his family by walking at his graduation

The young boy was diagnosed with Noonan syndrome, a rare genetic disorder that impacts mobility and development, at just 2 months old. He usually needs a wheelchair or walker to get around, but he shocked and thrilled his parents by standing up to receive his kindergarten diploma.

The brain doesn't seem to massively rewire following amputation—upending earlier beliefs about phantom pain

The findings, published in 2025, traced three amputees' brain-body maps and how they respond to body part movements—both before and after scheduled arm amputations. The unexpected neural stability suggests that the unchanged pathways for the missing limbs may explain why people continue to feel them so acutely.

Aphantasia involves a lack of mental images—but doesn't affect behavior

The condition, generally known about for over a century, first received its name in 2015 by researcher Adam Zeman. An estimated 4% of people lack this ability to perceive mental images, and research suggests this deficiency does not have any practical impact on behavior.

The first prenatal screen for disease was developed in 1961

Scientist Robert Guthrie created a method to test newborns for a metabolic defect called phenylketonuria, or PKU. This blood test didn't look for gene variants—it hunted for excess phenylalanine in the blood. The disorder is caused by an inability to digest the amino acid phenylalanine, leading to excess phenylalanine in the body. PKU results in intellectual disability, seizures, and other symptoms if it isn't caught early and treated with a specialized diet.

Drs. Jennifer Doudna and Emmanuelle Charpentier discuss CRISPR

Jennifer Doudna and Emmanuelle Charpentier's were awarded the 2020 Nobel Prize for research focused on understanding and adapting the CRISPR-Cas9 system to precisely edit DNA sequences in other organisms. Doudna has indicated that the system can potentially treat genetic forms of blindness and high cholesterol.

The research that led to sour

Scientists are trying to figure out if there are unique receptors that respond to the molecules that make up flavors we associate with calcium, blood, batteries, and other items that often escape dinner menus. Taste researcher Dr. Danielle Reed says the minimum evidence for a taste category typically involves identifying dedicated receptors and then removing them to show the taste vanishes.

The hormone that spreads love and helps fish share fear

Scientists consider emotions like fear and empathy to be among the oldest evolutionary behaviors observed in mammals. Yet to date, how these reactions are processed in the brain, regardless of species, is not well understood. A new study reveals how the chemical oxytocin—known as the "love hormone" in humans—helps let fish know when their friends are in danger.

Illustrator Ian Falconer's 'Olivia' piglet character was based on his niece

The New Yorker illustrator first began drawing fun pictures of a young pig named Olivia in the 1990s for his niece of the same name. Now, the books have sold millions and have been turned into a TV show. Meet the real Olivia behind the character in this brief interview.

Touch helps newborns regulate stress, gain weight, and feel less pain

Conclusions from this 2024 analysis from a team of Danish researchers included that touch interventions were particularly useful for newborns in regulating cortisol levels, helping newborns gain weight, and reducing pain. (Some users may experience a paywall.)

How a 6-year-old girl survived the wilderness of Arkansas alone for days

In 2001, a family trip to the Buffalo National River Wilderness in the Arkansas Ozarks took a dark turn, unfolding a tale of bizarre events when six-year-old Haley was lost and reportedly helped by the spirit of a little girl who resembled a child...

Nerve axons become damaged by leprosy, so patients may lose feeling in their skin

Infection of the peripheral nerves—nerves outside the brain and spinal cord—is a known complication of leprosy. That damage can cause patients to lose their sense of touch and the ability to feel pain or temperature in affected areas, leading to accidental injury.

'Fear of life closes off more opportunities for us than fear of death ever does.'

- Actress Agnes Moorehead (1900–1974)

Some Ozempic users lose their desire to eat

This essay follows a writer whose Ozempic journey involves a dramatic loss of appetite, leading them to stop compulsive snacking and even lose some of the joy of eating. As a result, he becomes fixated on watching food videos and eventually tries to "beat" an all-you-can-eat steak buffet. The experience leaves him feeling disappointed and lacking in desire.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Old Thom, the rare solitary orca

This orca has intrigued and perplexed scientists because of its seemingly docile existence separate from other orcas, which are known to be highly social beings.

Could all mental health disorders have a unifying 'p-factor'?

Some researchers have argued in the past couple decades that all mental health disorders may have a unifying dimension—a theoretical "p-factor" that is common across mental illness, but life experiences and behaviors influence if and how illness manifests. Proponents point to similarities across different disorders, while detractors argue that such connections are largely exaggerated.

Actresses Christina Applegate and Jamie-Lynn Sigler describe MS ignorance and stigma

Applegate discusses with Conan O'Brien how ignorance about the disease and fake cure information continue to proliferate. Sigler, known for her role on HBO's Sopranos, also discusses how she is now prioritizing roles that will have a disability, like her.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

American short story writer Flannery O'Connor raised 40 peacocks, which became potent symbols for her fiction's elegant violence

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon