Could all mental health disorders have a unifying 'p-factor'?

Gene expression patterns are similar between ASD, schizophrenia, and bipolar disorder

Postmortem brain tissue analysis suggests there are genetic and epigenetic similarities between individuals with autism, schizophrenia and bipolar disorder. All three conditions appeared to have activation of genes in astrocytes and suppression of specific genes that function at the junction between neurons, called synapses. (Some users may encounter a paywall.)

Having five of nine key symptoms constitutes a major depression

Before professional standards were adopted, practitioners used varying criteria to diagnose mental health disorders. By the 1970s, more objective lists were organized, culminating in this list of polythetic criteria—a list of symptoms where no single criterion is required, but a minimum number must be present.

Mental health symptoms may manifest differently across cultures

Mental health, like physical health, is imbued with values, beliefs, and traditions. Symptoms of distress are not universal and may differ based on racial, ethnic, and cultural contexts. Because mental health may be stigmatized or communities may have varying belief systems about causes of mental health challenges and how to fix them, it may affect how symptoms manifest. Chest pain, for example, may be a sign of mental distress—not the need for a doctor.

Panpsychism suggests that all matter possesses consciousness

The theory describes consciousness as a fundamental, ubiquitous property, rather than separate or emerging from matter. Cosmopsychism posits that the universe is conscious, while some critics argue that consciousness itself may be an illusion.

Can the gut microbiome influence personality?

New research suggests the bacteria in our gut—through the hormones and molecules they produce—can contribute to conditions ranging from depression to anxiety, and much more. The findings suggest diets have a direct impact on mental health and may lead to new therapies.

JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

Schildkraut was one of the first to put forward this idea, which stemmed from lab animal research. A decade later, researchers published the first landmark paper on fluoxetine—better known by trade name Prozac—which increases serotonin levels in the brain.

Psychology research shows that conspiracy theorists tend to have a desire to be unique

While conspiracy theorists are often understood to have feelings of powerlessness in their lives, research suggests they may also be inclined to set themselves apart from the masses.

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

PTSD is a long-lasting mental disorder linked to past traumatic events

Posttraumatic stress disorder is a mental health condition arising from traumatic events with four key symptoms: intrusive memories, avoidance behavior, negative moods and thoughts, and changes in emotional and physical reactions.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

Browse and explore dozens of major psychology theories

There are a ton of different psych theories—so here's a breakdown of some of the major ones according to the general psychological focus.

What's the difference between a psychologist and a psychiatrist?

While both psychiatrists and psychologists are mental health professionals, the big difference is that psychiatrists are medical physicians (MD or DO) while psychologists are not. Learn what makes these two profession different with this brief explainer.

Obsessive compulsive disorder is a mental health disorder, not a personality quirk

In popular culture OCD has been incorrectly overused to describe neatness or perfectionistic behaviors, but the disorder involves intrusive thoughts and compulsive behaviors that take over a person's actions.

Mental illness in the US costs roughly $282B annually nationwide

That figure, estimated as part of a 2024 Yale analysis that aimed to better understand the macroeconomic implications of mental illness, included the costs of mental health treatment, income loss, and overarching economic setbacks associated with mental illness.

Learn how Hollywood tries to get mental health portrayals right

"Entertainment is always the first priority," the director of medical research for "Grey's Anatomy" and "Private Practice" explained in this Newsweek article. But, medical consultants and dedicated groups like the University of Southern California's Hollywood, Health, and Society program, can help inform shows' characters, actions, and sensitivities on subjects like mental illness.

Its predictability distinguishes SAD from other forms of depression

Most major depression is "stochastic"—brought on without a clear trigger. SAD—also known as major depression with a seasonal component—is unique in that its onset is predictable. Many of those affected can predict its occurrence accurately within a range of three weeks. This podcast explores this unusual feature of SAD, among other expert takes.

Fruit fly experiments show personality emerges, in part, from genetic factors

A 2025 study revealed that fruit flies exhibit unique behavioral preferences, akin to personalities, which could be artificially selected for when breeding to modify behavioral variability. This variability can be adaptive in unpredictable environments.

Fear (and stress) can be contagious via pheromones secreted by the body

While seeing someone else in a panicked state may induce a stress response, researchers have found stress can be literally contagious—chemicals contained in sweat and other secretions can trigger stress hormone release in others. Theories suggest this feature is an evolutionary adaptation to protect groups from danger.

'The Father of Positive Psychology' gives tips on building resilience

People differ in how they respond to setbacks. Famed psychologist Martin Seligman outlines three key pillars for resilience: developing mental toughness by interpreting failures as external and temporary, recognizing and using one’s signature strengths, and cultivating strong relationships that offer support and meaning.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

A framework for the various potential causes of insomnia

Insomnia typically occurs in people dealing with life stressors and physical or mental health conditions, though the exact cause continues to elude researchers. Generally, the factors can be broken down into external (such as stress, medication, etc.) or internal (neurological) factors.

Many patients with psoriasis develop other autoimmune diseases, too

A small study published in 2024 found that nearly three-quarters of patients with psoriasis—a condition in which the body attacks healthy skin cells—also developed autoimmune disorders including thyroid diseases, connective tissue diseases, and more, suggesting such connections between these autoimmune disorders warrant further exploration.

What pupils can reveal about a person’s thoughts and feelings

Eyes have long been said to be the window to the soul. In this article, a psychologist and pupillometrist explores research demonstrating pupils as a window into the mind. Pupils tell us how intensely someone is exerting mental effort, or even reveal what a person is imagining. Read this article for insight into the field of pupillometry and how it can offer insights into our psyches.

Rodent evidence is mounting that dysfunctional mitochondria may be a cause of Parkinson's

Though researchers have long observed mitochondrial malfunction in Parkinson's patients, it has remained unclear whether faulty mitochondria cause the disease or are casualties of it. Rodent research published in 2025 adds further weight to the idea that it's causative.

Who provides therapy is more important than what method they practice

What makes therapy work well is the connection that patients feel with their therapist, and the trust in that relationship. Some research suggests that while the therapeutic model—say cognitive behavior therapy or psychodynamic therapy—accounts for roughly 15% of outcomes, the therapeutic relationship with the therapist accounts for more than 30%.

Can your identity be preserved amid dementia?

Memory loss associated with progressive dementia raises questions about whether a person's identity can be maintained during the disease's progression. One outlook suggests we define ourselves by our social relationships—offering a potentially more humane approach to caring for those with dementia.

What the heck is a polygenic risk score?

Being able to predict an individual’s risk of common conditions is regarded by many as the holy grail. So, where are we now?

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.