Rodent evidence is mounting that dysfunctional mitochondria may be a cause of Parkinson's

See this 201-level explanation about mitochondria and mitochondrial replacement therapy

This 2022 academic presentation from Stanford University's Dr. Gregory Enns offers a detailed overview about mitochondrial therapy approaches. Enns, a pediatric geneticist, explains how well-functioning mitochondria support the human body.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure

This podcast takes on the thorny mismatch between recent research linking herbicide exposure to Parkinson's disease and federal and state regulators' conclusions that there is insufficient evidence to establish causality. Though the main company that produces the herbicide Paraquat has recently stopped making it, dozens of others continue to do so, prompting concerns from some Parkinson's patients and scientists about disease risk and the pace of scientific answers. 

What rodent cars can tell us about human joy

Neuroscientist Kelly Lambert and her colleagues taught rats to drive in a mini car. She writes her findings from this unconventional experiment, sharing that positive and fun experiences can sculpt the brain just as powerfully as stressful ones. Click to learn more about how the apparent joy of these rodents seemed to enhance their neuroplasticity.

The reason some people love exercise may be because of their microbiome

Certain gut microbes in mice trigger dopamine release and drive motivation to exercise more. Scientists are investigating whether humans carry similar microbial patterns that influence our natural inclination towards movement, exploring how unseen microbial ecosystems may shape mammalian fitness behavior and reinforce innate reward pathways. (Some users may experience a paywall.)

How ALS (Lou Gehrig’s Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Mice were able to regenerate retinal cells in the lab—a breakthrough for mammals

Using gene therapy, a team of Korean researchers has enabled retinal regeneration in mice by blocking the intercellular transfer of a single inhibitory protein. This 2025 finding creates a new potential direction for treating retinal diseases. The work, which is still in animal studies, is projected to enter early-stage clinical trials in the next few years.

Memory disorders disrupt the brain's ability to make, store, or recall memories

These disorders stem from reversible issues like vitamin deficiencies or irreversible causes such as stroke or dementia. Only one type of dementia—familial Alzheimer’s disease—is directly inherited and accounts for about 20% of Alzheimer’s cases.

Face and neck massages improve the removal of brain cell waste products in mice

A study identified that massaging mice and monkeys' faces and necks enhanced the flow of cerebrospinal fluid. Because CSF has been shown to flush out proteins linked to Alzheimer's and Parkinson's, the research hints at non-invasive treatments to reduce the severity of these diseases.

Why death is caused by a dearth of ATP

Though people die from many causes, this video makes the case that a lack of adenosine triphosphate production in the body is what kills almost all of us. Without ATP, physiological processes grind to a halt, and organs stop functioning.

People with schizophrenia have triple the risk of developing diabetes

It remains contentious if something inherent about the disease or antipsychotics' side effects (weight gain) are mostly to blame. Some newly diagnosed schizophrenia patients already have insulin resistance, raising questions about if patients' brains are getting enough energy from glucose, and if dietary changes—like a high-fat, low-carbohydrate, moderate-protein diet—may help alleviate symptoms.

A super-sniffer smelled her husband's Parkinson's disease years ahead of symptoms

She discovered she could smell diseases, including Parkinson's, tuberculosis, Alzheimer's, cancer, and diabetes. Working with an analytic chemist, she's learned she can smell subtle changes in odor—ones that smell consistent across individuals with the same disorder—even before symptoms manifest.

Post-treatment Lyme disease syndrome may be caused by bacterial remnants in the liver

PTLDS, which refers to lingering symptoms of Lyme after antibiotic treatment, is an area of active research. Rodent research published in 2025 suggests that these ongoing symptoms may potentially be due to the body's inflammatory response to lingering cellular components from the bacteria that cause Lyme, Borrelia burgdorferi. In rodents, components of the bacteria's cellular wall may remain in the liver after the bacteria were eliminated with antibiotics.

Molecular evidence suggests the deadliest malaria parasite may be 100,000 years old

Plasmodium falciparum, the form of the parasite that kills the most humans, may date back 100,000 years, according to mitochondrial DNA analysis published in Science in 2003. It suggests that the parasite took off in humans about 10,000 years ago.

Scientists found that if cats in the lab ate infected rodents they could get West Nile

But beyond the lab setting there have been no known cases of cats or dogs contracting the virus this way. Instead, those animals have been sickened when an infected mosquito bit them—just as with human infection.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

Could all mental health disorders have a unifying 'p-factor'?

Some researchers have argued in the past couple decades that all mental health disorders may have a unifying dimension—a theoretical "p-factor" that is common across mental illness, but life experiences and behaviors influence if and how illness manifests. Proponents point to similarities across different disorders, while detractors argue that such connections are largely exaggerated.

A top Alzheimer's researcher was accused of faking results

In 2021, an investigation revealed photo manipulation in images from a seminal 2006 paper by researcher Sylvain Lesné on the role of amyloid plaques in progressive Alzheimer's disease. The revelation rocked the field, leaving many wondering whether they had tried to build on fabricated results. (Some users may experience a paywall.)

Sleep deprivation leads to buildup of danger molecules in the gut

Fruit flies genetically engineered to be awake for as long as they live tend to live half as long as their well-rested brethren. Analysis shows these modified flies suffer from a buildup of DNA-destroying reactive oxygen species in their guts. When enabled to sleep, the flies live as long as their counterparts.

Ménière's disease was first identified in 1861

This condition is named after the French clinician Prosper Ménière, who first identified it as being linked to the inner ear, noting it was a disorder of the semicircular canals. It tends to occur in people who are 40 years old or older.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Harvard drowned rats for this?

Harvard's 1950s rat study was ethically questionable, but scientifically profound. One rescue attempt made rats swim 40x longer. The finding: hope isn't poetic, it's biological.

Arteries with microplastic deposits linked to higher risk of cardiovascular events

Research shows that microplastics and nanoplastics can accumulate in major arteries, and patients with these deposits are significantly more likely to suffer heart attacks, strokes, or death. These deposits are possible due to these particles' ability to cross blood barriers.

Poliomyelitis is derived from Greek

Polio, formally called poliomyelitis, comes from the Greek words for gray (polios) and marrow (myelos)—a reference to the spinal cord tissue that, when infected by the virus, causes paralysis.

Large animals like giraffes and elephants have evolved unique cancer defenses

One may expect the larger an animal is, the more likely it is to develop cancer—simply because there are more cells and more chances for a dangerous mutation. However, some large animals show cancer rates almost 10 times lower than humans—a phenomenon known as Peto's Paradox.

The gaps in menopause research and their effects

Nearly all studies (99%) researching the biology of aging don’t consider menopause in their setup. A Harvard professor noted that about 75% of aging-related diseases are likely influenced by menopause. In this article, she discusses how gaps in research are negatively impacting how the medical system can effectively treat aging women. Read her analysis of the issue here.

Autoimmune diseases affect between 5% and 10% of people worldwide, but their causes remain unknown

Autoantibodies—which attack the body—may be detectable in the body years before a patient develops symptoms, but some people may have detectable levels yet never go on to develop an autoimmune disease. This video discusses this and other unsolved mysteries with autoimmune disease.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Scientists have struggled to pin down Ebola's natural reservoir species for decades, but the available evidence suggests that it's very likely fruit and insect-eating bats found in Africa.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The Ramones' 'Pet Sematary,' the theme song for the Stephen King novel of the same name, was written while the band was admiring the writer's collection of horror memorabilia.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

11 people died from firework injuries in the US in 2024.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls