Molecular evidence suggests the deadliest malaria parasite may be 100,000 years old

The most severe form of malaria is caused by the Plasmodium falciparum parasite

Multiple species of a single-celled organism called a protozoa cause malaria infection when transmitted by a mosquito bite. But Plasmodium falciparum is the most widespread in Africa, and the most deadly.

Genetic analysis suggests Anopheles mosquitoes fed on humans some 1.8 million years ago

The 2026 paper, based on 11 species of Anopheles mosquitoes found in Southeast Asia, suggests that mosquitoes in the region likely developed their human blood preference between 2.9 million and 1.6 million years ago, overlapping with when scientists believe Homo erectus arrived there. (Some users may encounter a paywall.)

There may be 500,000 additional malaria deaths by 2050

Research published in the journal Nature in January 2026 estimates that by 2050, climate change may trigger more than half a million additional malaria deaths and over 100 million additional malaria cases. The work is based on climate change projections and available disease information and did not incorporate new vaccine uptake.

Children under 5 account for 76% of all malaria deaths in Africa

The main hypothesis for why the disease hits this age group the hardest is that children this young have still-developing immune systems. Pregnant women and people with HIV/AIDS are also at higher risk of severe infection.

See this graphic of the complex malaria transmission lifecycle

Female Anopheles mosquitoes contract malaria by feeding on the blood of a human already infected with the disease-causing parasite. The parasite then develops in the mosquito's gut for one to two weeks before it migrates to the mosquito's salivary glands. Next, when the mosquito bites another person the parasite is delivered into the bloodstream of another human. This graphic further details what happens inside the human body during infection.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical

Charles Louis Alphonse Laveran won the Nobel Prize for his work "on the role played by protozoa" in causing diseases. His work included discovering and reporting the malaria-causing parasite in the blood of a patient suffering from malaria.

Mosquitoes are the world's deadliest animal—gene drives could kill them

Historically, killing all disease-carrying mosquitoes has not seemed practical and there are concerns about disrupting food webs. Gene editing to render female mosquitoes infertile creates the theoretical possibility of wiping out disease-carrying species, but concerns remain about effectively limiting this engineered trait to target species.

Measles evolved from an ancient cattle disease as early as 3,000 years ago

Genetic analysis suggests that the closest modern relative of measles is a livestock virus known as rinderpest, with the viral strains diverging between 2,000 and 3,000 years ago. The timing coincided with the rise of major cities above 250,000 people, offering a novel transmission route for the newly mutated measles virus.

Untreated malaria can lead to blocked blood vessels in the brain, coma, and organ failure

Malaria is treatable with medications, but sometimes even after treatment, infection can come back because the disease-causing parasite wasn't completely eliminated. Patients may also have symptoms that emerge years after the initial infection and treatment.

Marburg virus, related to Ebola, is also extremely deadly

Discovered nine years before Ebola, Marburg is part of the same filovirus family. While this virus is less contagious, it can still be deadly. Currently, no vaccines exist against this disease. (Some users may encounter a paywall.)

Florida reports 71 imported malaria cases annually—4% of all the US cases

The Sunshine State reports an average of 71 imported malaria cases annually. Malaria isn't endemic to Florida but mosquitoes in the state are biologically capable of transmitting the disease from one infected person to another noninfected person.

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

The Paranthropus genus, our mysterious extinct cousins

In the last century, skull and jaw fragments have been discovered in East Africa suggesting an ancient hominin species lived, evolved, and died alongside humanity's ancestors. With large, broad skulls and strong jaws, the Paranthropus genus—which includes several related species—is an absorbing case of the effects of niche partitioning, where species coexist by adapting differently to the environment. Paranthropus died out and human ancestors endured. Find out why here.

Flowers have been around for 123 million years

Fossilized pollen grains reveal that flowering plants have existed on Earth for 123 million years, and their emergence considerably enriched the planet's biological diversity. They may also have been more widespread than initially thought—prior assumptions were that the eudicots, the first flowering plants, appeared 121 million years ago.

Fossils suggest tardigrades developed cryptobiosis more than 180 million years ago

As of 2024, three tardigrade fossils have been discovered, all preserved in amber. Analysis suggests different species of the organism existed over 500 million years ago, when marine heterotardigrades and freshwater terrestrial eutardigrades diverged. (Some readers may experience a paywall.)

Recent research indicates leprosy was present in the Americas before European settlers

New research published in 2025 upended long-held notions that the disease was introduced to the Americas by European colonizers. Evidence of a lesser-known leprosy-causing bacterium was found in ancient human remains that date back 4,000 years.

Most fungal pathogens can't survive the heat of our bodies

Fungal pathogens typically struggle to survive human body temperatures, but researchers hypothesize that global warming conditions will force fungi to adapt to hotter temperatures, with implications for their ability to also survive within our bodies. That type of evolutionary adaptation would lead to more dire health threats for humans.

The ‘humongous fungus’ may be the largest organism on Earth at more than 2,300 acres

Discovered in 1988, when it was only covering 400 acres, this massive colony of Armillaria ostoyae, based in Oregon, has taken hold among the tree roots of the Malheur National Forest. It consists of a vast network of unique long black filaments of fungal tissue called rhizomorphs that grow under the soil and infect tree roots, nourishing the fungus but killing the trees. Researchers believe this fungal growth dates back more than 8,000 years and currently weighs approximately 35,000 tons.

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

Most invasive species are spread accidentally by human activity

In the Florida Everglades, Burmese pythons were only found as pets in the 1980s, but their escapes and releases since then have led to a population of hundreds of thousands as of 2024. The spotted lanternfly—native to Asia—was first detected in Pennsylvania in 2014 and has since spread to about 20 states by hitchhiking.

MS can damage the brain up to 7 years before symptoms appear

Recent research scouring blood samples from 134 people with MS, both before and after their diagnosis, found that about seven years before these patients were diagnosed, there was a spike in a protein called myelin oligodendrocyte glycoprotein—indicating disease-associated damage to the protective myelin around nerve fibers.

Rodent evidence is mounting that dysfunctional mitochondria may be a cause of Parkinson's

Though researchers have long observed mitochondrial malfunction in Parkinson's patients, it has remained unclear whether faulty mitochondria cause the disease or are casualties of it. Rodent research published in 2025 adds further weight to the idea that it's causative.

The Ishango bone suggests mathematics was born about 20,000 years ago

Ancient civilizations developed mathematical systems for various purposes, including the Egyptians for the construction of the pyramids and the Ancient Greeks for logical reasoning in theorems. However, these systems were predated by the Ishango bone—found in the Democratic Republic of the Congo—whose notches suggest a base ten system, prime numbers, and simple mathematical operations.

The history of malware includes computer viruses, worms, trojans, and ransomware

Some of the earliest significant pieces of malware—the Creeper worm and the Elk Cloner virus—displayed silly messages to users without causing major harm. As computer science has advanced, malware has become more easily spread, incorporated social engineering to manipulate users, targeted infrastructure systems, and been used by governments for virtual espionage.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

View the ten deadliest tornadoes in US history.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.