Genetic analysis suggests Anopheles mosquitoes fed on humans some 1.8 million years ago

How we helped make Aedes aegypti mosquitoes such a problem

Mosquito genome sequencing data suggests that Aedes aegypti mosquitoes first started specializing on human blood around 5,000 years ago—when climates shifted and humans started domesticating plants in Africa and stored large amounts of water that may have attracted the bugs.

See this graphic of the complex malaria transmission lifecycle

Female Anopheles mosquitoes contract malaria by feeding on the blood of a human already infected with the disease-causing parasite. The parasite then develops in the mosquito's gut for one to two weeks before it migrates to the mosquito's salivary glands. Next, when the mosquito bites another person the parasite is delivered into the bloodstream of another human. This graphic further details what happens inside the human body during infection.

Molecular evidence suggests the deadliest malaria parasite may be 100,000 years old

Plasmodium falciparum, the form of the parasite that kills the most humans, may date back 100,000 years, according to mitochondrial DNA analysis published in Science in 2003. It suggests that the parasite took off in humans about 10,000 years ago.

Researchers are breeding genetically modified mosquitoes to be malaria-resistant

Using CRISPR, a team of international researchers is genetically modifying Anopheles in the lab to be malaria-resistant. The insects would be released into the wild to mate with the wild population, passing down this trait. As of early 2026 they had not yet released the mosquitoes into the wild for field trials. Separate CRISPR work seeks to reduce the Anopheles population altogether.

Some mosquitoes are key pollinators—and eat disease-carrying mosquitoes

​​There are more than 3,500 species of mosquitoes, and only a small fraction of them bite humans. They also play vital roles in the ecosystem: One young elephant mosquito, for example, can eat dozens of smaller mosquitoes that bite humans in just one day. Sometimes mosquito-gobbling species are released by humans to control other mosquitoes.

Mosquitoes drink a maximum of 0.01 milliliters of blood in a single meal

That's roughly equal to a human drinking the contents of an entire bathtub. Females, which are the only ones that drink blood, have a sensory nerve that signals when they're getting full, but if it's disabled, a mosquito would keep drinking until it bursts—a scientist conducted that experiment.

Why genetic similarities between humans suggest a past near-extinction event

Researchers have found that low genetic diversity among humans—even those on opposite sides of the planet—may result from a breeding population of as few as 1,280 adults, estimated to have existed 930,000 years ago. This genetic bottleneck may have resulted from a near-extinction or from a small population of human ancestors, from which we all descend, that broke off from a larger population.

Genetics may account for nearly 67% of mosquito attractiveness

In a mosquito attraction study published in 2015, identical twins appeared equally attractive to mosquitoes in lab tests, whereas some nonidentical twins were far less likely to be bitten than their siblings. Other work related showed that body odor is also more similar between identical twins.

HIV originated in Central and West Africa from a virus in chimpanzees

Researchers believe the virus crossed from chimpanzees to humans through bushmeat practices in the early 20th century, with genetic studies suggesting the most recent common ancestor of the HIV-1 M group, which is responsible for the global AIDS pandemic, emerged around 1910–1930 in Léopoldville (now Kinshasa) in the Belgian Congo.

Ancient humans settled Australia more than 50,000 years ago

Archaeological evidence shows that modern humans reached Southeast Asia about 70,000 years ago and they spread to Australia by at least 50,000 years ago. It marks the oldest evidence of open-sea migration by humans on record.

Blood evolved many times over hundreds of millions of years

The earliest evidence of a blood-like substance comes from ancient arthropods, which appear to have had copper-based blood. In the 500 million years since then, some creatures have grown to rely on other variants, such as humanity's iron-based blood.

Humans may be the ultimate invasive species

Originating in East Africa, Homo sapiens migrated across the world beginning about 60,000 years ago and directly harmed countless species by consuming resources and modifying ecosystems to serve our needs. While meeting the definition of an invasive species, some ecologists argue the opposite, claiming that humans have helped preserve numerous species.

Studies estimating the number of years between human generations suggest there have been approximately 10,000 to 12,000 generations of humans.

Research has found that the length of human generations has varied throughout the 300,000 years that Homo sapiens have been around, ranging from about 25 to 30 years. These values come from analyzing genetic mutations, since the blend of them passed onto children changes as parents age.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Up to 8% of the human genome consists of ancient viral DNA

Human endogenous retroviruses are remnants of infections that affected human primate ancestors millions of years ago and were passed on by infiltrating sperm and egg cells. Studies have shown that this DNA may play a role in immune responses and in placental formation.

Measles evolved from an ancient cattle disease as early as 3,000 years ago

Genetic analysis suggests that the closest modern relative of measles is a livestock virus known as rinderpest, with the viral strains diverging between 2,000 and 3,000 years ago. The timing coincided with the rise of major cities above 250,000 people, offering a novel transmission route for the newly mutated measles virus.

Bees evolved from meat-eating wasps that became vegetarian

After flowering plants first appeared approximately 140 million years ago, some wasp diets would have changed as they consumed pollen-coated insects that would visit these plants. Bees that branched from these wasp species also developed long tongues to slurp nectar and ultraviolet vision to identify flower patterns unseen by humans.

Lyme disease-causing bacteria predate any suspected biological weapons testing

Borrelia bacteria existed long before any US biological weapons program—or human presence in North America. One study comparing genomes of the bacteria behind Lyme disease collected samples of the bacteria over three decades and calculated that the bacterium has been in North America longer than humans, at least 60,000 years. Other work found related bacteria preserved in amber from millions of years ago.

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

Culicidology is the study of mosquitoes

This deep dive mosquito science podcast states that the word culicidology dates back to the 1970s, and comes from the Latin word for "midge"—a separate, tiny biting insect. It first appeared in a book review about a book called "Mosquitoes of New York."

How do we know what prehistoric humans ate?

Without recourse to ancient menus, how can historians know what our ancient human ancestors—as far as 3 million years ago—ate on a daily basis? Researchers evaluate several factors, including the type of teeth the species had evolved, chemical analysis of the teeth, patterns of wear and tear on teeth, as well as food scraps found in the vicinity of ancient remains. Learn the approach to discovering ancient hominin diets.

See a timeline of landmark discoveries in the field of genetics

From the first genetic map of fruit fly genes in 1911 through the completion of the Human Genome Project in 2003, scientists have built upon each other's discoveries to further our knowledge of the human body and the genetic instructions that inform our traits and disease risks.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Scientists have struggled to pin down Ebola's natural reservoir species for decades, but the available evidence suggests that it's very likely fruit and insect-eating bats found in Africa.

The American cockroach is actually from Africa—an apparent hitchhiker aboard ships carrying enslaved people—with evidence suggesting it may have arrived in the New World as early as the 1600s

This podcast delves into the history of Periplaneta americana and explores why the bugs elicit such fear, disgust, and, at times, shame. The bug likely climbed aboard the slave ships because they had both unprotected food sources and places to hide during their journey.

Scientists can suck animal DNA from the air

A look at how researchers filtered the air around two zoos and identified genetic material from dozens of species, a technique that could help track and conserve wildlife.

Fossils suggest tardigrades developed cryptobiosis more than 180 million years ago

As of 2024, three tardigrade fossils have been discovered, all preserved in amber. Analysis suggests different species of the organism existed over 500 million years ago, when marine heterotardigrades and freshwater terrestrial eutardigrades diverged. (Some readers may experience a paywall.)

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.