Mosquitoes are the world's deadliest animal—gene drives could kill them

What if we killed every mosquito on Earth?

Mosquitoes aren't just annoying, they're deadly. they're also responsible for an estimated 725,000 deaths worldwide, every year. Would it be so bad if we found a way to wipe them out completely? Real scientists have gamed out this hypothetical scenario, concluding it actually wouldn't be that bad. This five-minute video breaks down one way this could happen.

Malaria mosquitoes in a lab were wiped out using CRISPR

Scientists at Imperial College London disabled a gene in female Anopheles gambiae mosquitoes to make them infertile and propagated the infertility mutation at unnaturally high rates using a gene drive. The entire population collapsed within a dozen generations, showing promise for subsequent with mosquitoes in mimicked tropical environments.

Mosquitoes top the ranking of the world's deadliest animals

Mosquitos kill about 760,000 people every year. The vast majority of those deaths are caused by malaria, which is transmitted and spread by the Anopheles mosquito. The second-place deadliest animal title goes to snakes, with an estimated human death toll of around 100,000 annually.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

Some mosquitoes are key pollinators—and eat disease-carrying mosquitoes

​​There are more than 3,500 species of mosquitoes, and only a small fraction of them bite humans. They also play vital roles in the ecosystem: One young elephant mosquito, for example, can eat dozens of smaller mosquitoes that bite humans in just one day. Sometimes mosquito-gobbling species are released by humans to control other mosquitoes.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Explore inside a mosquito factory where millions of mosquitoes are bred weekly

In Medellin, Colombia, scientists are infecting Aedes aegypti mosquitoes with Wolbachia, a bacterium that wouldn't otherwise infect the species, but does block its ability to transmit dengue, Zika, yellow fever, and chikungunya. In the wild, infected mosquitoes would breed with wild mosquitoes, pass down Wolbachia, and thus reduce disease transmission.

Genetic engineering mice is one idea to reduce Lyme disease transmission

Wild white-footed mice are the main carriers of Lyme. A research team is hoping to genetically engineer mice, using CRISPR, to make the animals immune to Lyme. They're proposing a field trial where they would insert a gene with an antibody to Lyme infection to break the disease transmission cycle on a private island and then try it in Nantucket if that goes well. Simply killing the mice isn't an option because it would upend food webs. Unlike traditional vaccines, this "heritable immunization" would pass from one generation of mice to the next.

How we helped make Aedes aegypti mosquitoes such a problem

Mosquito genome sequencing data suggests that Aedes aegypti mosquitoes first started specializing on human blood around 5,000 years ago—when climates shifted and humans started domesticating plants in Africa and stored large amounts of water that may have attracted the bugs.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Billions of flies are being dropped from the sky

The US is dropping billions of sterile flies to stop a deadly parasite. Screwworm maggots eat animals alive, so scientists are collapsing the population by ensuring females can’t reproduce.

Mosquitoes drink a maximum of 0.01 milliliters of blood in a single meal

That's roughly equal to a human drinking the contents of an entire bathtub. Females, which are the only ones that drink blood, have a sensory nerve that signals when they're getting full, but if it's disabled, a mosquito would keep drinking until it bursts—a scientist conducted that experiment.

Mosquito-borne illnesses have killed captive orcas at SeaWorld

After two SeaWorld orcas died from viruses carried by mosquitoes, scientists warn that mosquito-borne illnesses may be a bigger threat to these captive animals than previously known. Captive orcas spend a lot of time stationary, close to the surface, unlike their wild counterparts. Researchers saw mosquitoes landing on the animals' backs, heads, and dorsal fins, supping on their blood.

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases

Researchers in China tested a transmissible rabies vaccine in the lab by feeding mosquitoes blood containing the vaccine and observing what happened to bats when they were either bitten by the mosquitoes or fed on them. The bats developed antibodies against rabies and survived subsequent rabies infection. (Some users may encounter a paywall.)

Iceland, the last mosquito-free country, detected them in 2025

Recently several of the mosquito species Culiseta annulata were documented in Iceland—the last country that had not yet seen them, underscoring that climate change is shifting the bugs' patterns. Mosquitoes can hide out in human structures to survive icy temperatures. The bugs are now known to live everywhere except the continent of Antarctica.

Anopheles mosquitoes are developing resistance to insecticides

The malaria-transmitting mosquito species is developing resistance to the insecticides used in insecticide-treated bed nets and in indoor spraying in people's homes and communities. Malaria parasites are also developing resistance to antimalarial drugs.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Mosquito necroprinting uses an insect's mouthpart as the printer nozzle

Mosquitoes are abundant, and their nozzles are 32-100 times cheaper to harvest than to create from scratch out of metal or glass. By coating the organic nozzle to increase its strength, researchers are employing necroprinting to create tiny structures at better resolutions than commercial alternatives.

Twin studies helped scientists understand why mosquitoes like some of us more than others

A combination of carbon dioxide output, skin chemistry, genetic factors, hormones, and clothing choice can make us particularly vulnerable to mosquito bites. Watch how mosquitoes responded to one man in the video versus his wife, a research approach typically conducted with identical and fraternal twins to test mosquito attractiveness.

How Disney World keeps out mosquitos

Disney World may have been built on a swamp, but it's nearly free from the annoyance of mosquitos. That hasn't been an easy task; Disney has worked with engineers and pest specialists on minimizing the invasive bugs through a variety of different methods. This Reader's Digest article breaks down how they've successfully kept the park free from these unwanted guests.

Mosquitoes stop flying at wind speeds equivalent to the swishing of a horse's tail

This low-threshold for wind—halting flight at 2 to 3 miles per hour—underscores that the bugs are actually not particularly strong flyers. But they don't need to be particularly robust fliers since their tiny, dark bodies and erratic movements can make them challenging to spot.

There may be 500,000 additional malaria deaths by 2050

Research published in the journal Nature in January 2026 estimates that by 2050, climate change may trigger more than half a million additional malaria deaths and over 100 million additional malaria cases. The work is based on climate change projections and available disease information and did not incorporate new vaccine uptake.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Culicidology is the study of mosquitoes

This deep dive mosquito science podcast states that the word culicidology dates back to the 1970s, and comes from the Latin word for "midge"—a separate, tiny biting insect. It first appeared in a book review about a book called "Mosquitoes of New York."

Why physiology and genetics prevent king bees from existing

The mating process is fatal to male honey bees, as their endophallus detaches from their bodies and remains temporarily within the queen. Because fertilized honey bee eggs develop into female bees, if a male somehow did survive and become king, his line of succession would also abruptly end.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Experts suggest there is a 10% chance AI will cause human extinction

AI superintelligence may hijack infrastructure, including power grids and transportation systems, if it surpasses human controls. It may also design unstoppable pathogens or deplete resources, like electricity, meant for human use.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

View the ten deadliest tornadoes in US history.

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

Hotels in Cannes, the glamorous city on the French Riviera, hire hawks to ward off seagulls during the city's famous film festival.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.