Genetic engineering mice is one idea to reduce Lyme disease transmission

Researchers are breeding genetically modified mosquitoes to be malaria-resistant

Using CRISPR, a team of international researchers is genetically modifying Anopheles in the lab to be malaria-resistant. The insects would be released into the wild to mate with the wild population, passing down this trait. As of early 2026 they had not yet released the mosquitoes into the wild for field trials. Separate CRISPR work seeks to reduce the Anopheles population altogether.

Mosquitoes are the world's deadliest animal—gene drives could kill them

Historically, killing all disease-carrying mosquitoes has not seemed practical and there are concerns about disrupting food webs. Gene editing to render female mosquitoes infertile creates the theoretical possibility of wiping out disease-carrying species, but concerns remain about effectively limiting this engineered trait to target species.

Land use changes in Connecticut may have helped to enable Lyme's leap into humans

Forest clearing and fragmentation, alongside suburban development, may have contributed to the emergence of Lyme disease in humans in the 1970s. Those changes brought mice, carriers of the disease, into greater contact with people. Climate change is also facilitating Lyme's spread as tick populations survive milder winters and move northward.

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases

Researchers in China tested a transmissible rabies vaccine in the lab by feeding mosquitoes blood containing the vaccine and observing what happened to bats when they were either bitten by the mosquitoes or fed on them. The bats developed antibodies against rabies and survived subsequent rabies infection. (Some users may encounter a paywall.)

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Mice were able to regenerate retinal cells in the lab—a breakthrough for mammals

Using gene therapy, a team of Korean researchers has enabled retinal regeneration in mice by blocking the intercellular transfer of a single inhibitory protein. This 2025 finding creates a new potential direction for treating retinal diseases. The work, which is still in animal studies, is projected to enter early-stage clinical trials in the next few years.

Wolbachia is a naturally occurring bacterium being employed to fight dengue

Scientists are fighting dengue spread in a roundabout way: injecting bacteria into Aedes aegypti mosquito eggs, which blocks the dengue virus from replicating in the tissue of mosquitoes. Researchers hope the bacterium will be passed to future generations, inoculating them against dengue. Wolbachia is also being investigated to combat other mosquito-borne diseases.

Deer don't get infected with Lyme disease—but ticks do feed on them

Adult ticks feed on white-tailed deer and also lay eggs on the animals, but the deer don't get sick with Lyme disease. Research published in 2023 offered new insights into why deer don't get sick from Lyme disease: It appears that the quadruped may have specific not-yet-identified immune system proteins in their blood serum that kill the bacterium.

Leprosy bacteria are sometimes grown on mouse feet for research

The main leprosy-causing bacterium can't be grown in a petri dish, so the disease is challenging to study in the lab. For research purposes, it has been grown in the foot pads of mice.

Gut microbiome rewrites may help reduce allergies

Researchers are investigating different strategies to determine if one day they could give people a combination of gut microbes to set them up for fewer allergies. In animal research, scientists have already prevented severe allergic responses in allergy-prone mice—supplying them with gut microbes from healthy, non-allergic human babies.

Two Lyme disease vaccines were in development in 2026

As of early 2026, there was no vaccine for Lyme disease available. One candidate vaccine, VLA15, was in later-stage clinical trials. Another designed to provide seasonal protection was licensed to a pharmaceutical company in 2025, and was planned for human clinical trials.

Post-treatment Lyme disease syndrome may be caused by bacterial remnants in the liver

PTLDS, which refers to lingering symptoms of Lyme after antibiotic treatment, is an area of active research. Rodent research published in 2025 suggests that these ongoing symptoms may potentially be due to the body's inflammatory response to lingering cellular components from the bacteria that cause Lyme, Borrelia burgdorferi. In rodents, components of the bacteria's cellular wall may remain in the liver after the bacteria were eliminated with antibiotics.

Genetic engineering will change everything forever

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. As scientists increasingly understand how specific genes cause disease, the possibility of engineering our genes to not only "fix" problems but enhance our natural ability grows.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Billions of flies are being dropped from the sky

The US is dropping billions of sterile flies to stop a deadly parasite. Screwworm maggots eat animals alive, so scientists are collapsing the population by ensuring females can’t reproduce.

Scientists found that if cats in the lab ate infected rodents they could get West Nile

But beyond the lab setting there have been no known cases of cats or dogs contracting the virus this way. Instead, those animals have been sickened when an infected mosquito bit them—just as with human infection.

Model organisms like yeast, mice, and flies help scientists decode the human body

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

Scientists are using CRISPR to crossbreed heat-resistant corals amid warming reefs

Inside Australia's National Sea Simulator, coral hybrids are genetically engineered to resist the widespread coral bleaching caused by rising global temperatures. Early trials have developed groups with survival rates up to 34 percentage points higher than nonhybrids. (Some readers may experience a paywall.)

Long-term evolution experiments use microbe's short generations to speed up selection

With quick generations of microbes, scientists can speed up the evolutionary process, with projects like the LTEE in California running for 40 years and generating 80,000 generations of E. coli.

Supplements ahead of exertional heatstroke helped protect mice against brain damage

In the lab, mice dosed with probiotics prior to inducing exertional heatstroke, had better cognitive outcomes. This evidence underscores the links between the gut microbiome and the brain, at least in rodents.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Alpha-gal allergy is a problem for red meat lovers, and that same sugar is an issue for xenotransplants, too

In recent years, researchers have discovered ticks can induce spontaneous meat allergies in people they bite, a particularly problematic condition for previous meat lovers. This 18-minute podcast from RadioLab breaks down the cause.

Bacteria have been genetically engineered to bioluminesce when wine has spoiled

Developed by researchers at Hebrew University, the method involves the firefly enzyme luciferase, which emits light from within bacteria expressing when they are in the presence of acetic acid vapors produced by wine. The process provides affordable, on-site, real-time monitoring of fermentation quality.

TIGR may supplement CRISPR by providing more refined DNA targeting

The tandem interspaced guide RNA is primarily found in viruses—unlike CRISPR, which is bacterial in origin—and is smaller than CRISPR, making it easier to deliver into cells. The TIGR-Tas system appears to read both sides of the DNA double helix and opens a smaller segment of DNA for repairs, improving the precision of single letter modification.

Superbugs evolve defenses against medication, then share them with neighbors

One reason antibiotic resistance spreads so quickly is that bacteria have multiple mechanisms allowing them to share genetic material. This short video offers a concise explanation for each of these mechanisms, and animation that helps viewers understand how antimicrobial resistance can quickly spread from one organism to another.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Cordyceps: the fungi that turn ants into zombies

The hit show (and video game) "Last of Us" was inspired partly by real-life species of fungi that have been known to turn ants into zombies. Spores of the Cordyceps fungi are capable of penetrating the exoskeletons of arthropods, after which they break into enzymes and proliferate within the body. The fungal cells then hack the ant's nervous system and trigger compulsive climbing.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Hotels in Cannes, the glamorous city on the French Riviera, hire hawks to ward off seagulls during the city's famous film festival.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.