Long-term evolution experiments use microbe's short generations to speed up selection

Model organisms like yeast, mice, and flies help scientists decode the human body

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

Explore the independent lines of evidence behind the theory of evolution

Gradual changes in organisms have been directly observed through artificial selection—humans purposely selecting organisms to breed to pass on specific traits—and in organisms with short lifespans, such as insects and microbes. Analyses of DNA and anatomical structures across different species, as well as fossil records, also reveal ancient shared ancestry consistent with natural selection.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Microbial research suggests shifts in diverse populations may help an invasive species establish itself

In 1958, English ecologist Charles Elton suggested that diverse ecosystems should be more resistant to invasive species because gaining a foothold would be more challenging when resources are more thinly spread. However, in lab-grown microbial ecosystems with greater biodiversity, population volatility opened more ecological roles that invasive species could easily fill.

Bacteria rapidly evolve (and share) new defenses against drugs they encounter

Unlike humans, bacteria rapidly make genetic changes in response to their environment, including creating defense against antibiotics. Furthermore, these defenses are passed on to their future generations and can even be shared with neighboring bacteria through horizontal gene transfer.

'Endoevolution' refers to the Darwinian selection happening continually inside us

The term, coined by Roxanne Khamsi in her 2026 book "Beyond Inheritance: Our Ever-Mutating Cells and a New Understanding of Health" describes the idea that evolution does not just occur across generations of humans. Instead, mutated cells continuously compete with healthy ones in our bodies, with implications for our tissues and health. Khamsi says these autocorrections are essentially natural gene therapy. 

Genetic engineering has accelerated millennia of altering various crops' genes

Although farmers have long cross-bred crops to obtain plants with specific colors, sizes, and other characteristics, these processes took significant time. Today, genetic modification in agriculture involves scientists altering an organism's DNA for various purposes, including enhancing pathogen resistance, removing allergens, and delaying spoilage.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Is human evolution speeding up or slowing down?

In the past 3,000 years, many populations have evolved genetic adaptations to their local environments. People in Siberia and the high arctic are uniquely adapted to survive extreme cold. The Bajau people can dive 70 meters and stay underwater for almost 15 minutes. So what are other recent changes? And will our technological innovations impact our evolution?

Leprosy bacteria replicate extremely slowly—only once every two weeks

Mycobacterium leprae has a long incubation period and a very slow replication rate, taking roughly 12 to 14 days to make a copy of itself and divide. In contrast, bacteria like E. coli can replicate in about 20 minutes in ideal conditions. Someone can be infected for years without experiencing any symptoms. This also makes the disease difficult to treat. This video describes the knowns—and unknowns—about this infectious bacterium.

Global life expectancy has more than doubled since the 1850s

The human species experienced a dramatic increase in expected lifespan over the past 150 years. Antibiotics, improved sanitation, and better worldwide food distribution are a few factors contributing to this rapid transformation. Use this interactive resource to explore longevity gains over time and compare these improvements across the globe.

Genetic engineering mice is one idea to reduce Lyme disease transmission

Wild white-footed mice are the main carriers of Lyme. A research team is hoping to genetically engineer mice, using CRISPR, to make the animals immune to Lyme. They're proposing a field trial where they would insert a gene with an antibody to Lyme infection to break the disease transmission cycle on a private island and then try it in Nantucket if that goes well. Simply killing the mice isn't an option because it would upend food webs. Unlike traditional vaccines, this "heritable immunization" would pass from one generation of mice to the next.

Where do genes come from?

There are many more genes on Earth today than when microbial life first spawned on the planet about four billion years ago. Many of these newer genes grew from genetic mutations, misprints that slowly drift from the original blueprint via cellular division. If these mutations drift far enough, they can establish a new family of genes, though this process can take well over a million years.

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

Solutions of bioluminescent bacteria can create FOMO-inducing living art

A 2002 exhibition at Montana State University-Bozeman placed the bacteria onto petri dishes that served as macroscopic pixels to create images. Once the bacteria finished eating all the food in the sealed dishes, the light slowly faded away, ending the exhibit.

Ticks survived 27 years in a lab, including eight without food

Research published in 2022 set a new record for tick longevity. A group of adult African ticks that are normally found in eastern and southern Africa lived in a laboratory for 27 years, including eight without food. What's more, one of the females laid eggs at least four years after the last male died. Most ticks, on average, reportedly live for six months to three years.

Multiple new research paths may lead to slowing (or even reversing) aging

Aging has always been inevitable, but fasting, epigenetic reprogramming, and parabiosis seem to help people stay young. By studying centenarians, memory, and even the humble roundworm, scientists are looking for the genetic basis to live not just a long life, but a healthy one.

Learn how environmental conditions are optimized to increase bioremediation efficacy

Through biostimulation, Indigenous microbes are provided with moisture, nutrients, or oxygen to prevent their death and ensure optimal progression of their biochemical reactions. Bioaugmentation can introduce new microbial cultures to target specific compounds not natively found in the environment, while landfarming can spread or aerate contaminated soil to improve access to contaminants.

Microgravity can alter the evolution of viruses and bacteria

Experiments conducted on the International Space Station have shown that microgravity environments can delay viral and bacterial infections and induce mutations not seen on Earth. These mutations could have implications for long-term space missions and human health and suggest space can serve as a testing ground for developing new therapeutic approaches.

Lining up every microbe on Earth would stretch to about 105,000 light-years

There are about 10²⁷ such organisms on the planet, many of which are adapted to produce energy through uncommon reactions in unconventional environments, such as within rocks or near volcanoes on the ocean floor. Studies of these organisms have reframed astrobiologists' search for life beyond Earth by broadening the parameters under which life can exist.

What's next for gut microbiome science?

A Stanford microbiologist explores what we don't yet know about the gut microbiome—such as whether we can engineer the bacterial species within it—and the current scientific advances in the field.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

The Human Genome Project was forced to accelerate due to a private competitor

Despite a 15-year target when it began in 1990, the Human Genome Project faced competition from Celera Genomics when it entered the sequencing race in 1998. Celera's aim to complete the human genome in three years pressured the HGP to complete their sequencing several years ahead of schedule.

Cells cannot grow forever due to escalating inefficiency in transporting chemicals

As cells get larger, their volume grows much faster than the surface area through which nutrients and waste products pass, creating a bottleneck that eventually causes cells to die. This forces nearly all organisms visible to the naked eye to comprise enormous numbers of smaller cells, such as the approximately 30 trillion found in the average adult human.

What a tiny marine worm can tell us about our brains

Meet the amphioxus, a small eel-like animal that has a lot to teach us about brain evolution. The genetic roots of our brains can be seen in these unusual creatures. This three-minute educational video focuses on the evolutionary history of the human brain through these odd little critters with a 500-million-year-old history.

Watch tardigrade samples under an optical microscope

Tardigrade samples can be collected by gathering moss and submerging it in tap water for 24 hours. The moss should then be cut and drained with a mesh sieve, and the water should be collected. Samples are observable in the water between 10x and 40x magnifications.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

A century of Billboard issues documenting the evolution of popular music.

Despite being favored by 87% of Americans, Congress does not have term limits.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.