Tech entrepreneur Bryan Johnson's mission to live forever

Inside entrepreneur Bryan Johnson's race to live forever

Created by entrepreneur Bryan Johnson in 2022, the Rejuvenation Olympics asks participants to find ways, including exercise and dietary supplements, to slow their biological aging. But some of these tactics are extreme in cost or nature—such as Johnson's regular injections of blood from his teenage son.

Dave Asprey is considered one of the fathers of modern biohacking

Entrepreneur Dave Asprey wants to live longer than anyone else, a desire that's led him to biohacking. Asprey relies on supplements, stem cell treatments, rigid dieting, exercise, and more. The inventor of Bulletproof Coffee has no medical or nutritional training, though that's not unusual among biohacking's DIY experimenters.

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

Hacking the body for a future that didn't happen

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

The scientist that biohacked a buff frog

If a tree frog was injected with a DNA mixture containing follistatin, a gene that may influence muscle growth, would it become buff? Josiah Zayner hopes so. By learning how to biohack animals, he hopes people are one step closer to feeling more comfortable "whipping up DIY gene therapy."

How personalized gene-editing saved a baby's life

KJ Muldoon had a 50% chance of surviving a genetic mutation until doctors developed a one-of-a-kind gene-editing therapy. In an interview with one of the researchers behind the treatment, learn what it will take to make personalized genetic medicine possible for everyone.

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

Meet the investor running his life with AI

Daniel Ha is a venture capitalist who built a suite of AI agents to boost his productivity, both professionally and personally. At his VC firm, a troupe of agents gathers data on startups and analyzes it from competing perspectives to produce a confidence score. When his dad was diagnosed with cancer, Ha used an oncology-trained AI to help him understand the condition.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

How to prevent a worst-case scenario with synbio

Author and entrepreneur Rob Reid reviews the risks of a world where more and more people have access to the technology needed to create a doomsday bug that could wipe out humanity.

The origin of cyborgs

The term "cyborg" was coined in a 1960 academic paper discussing what alterations humans would need to undergo to survive in extraterrestrial environments, a venture far "more logical than providing an earthly environment" in space. According to authors Manfred E. Clynes and Nathan S. Kline, Cyborgs with a capital C have incorporated exogenous components that extend their ability to adapt to new environments. Read the paper here.

The world's first commercial biological computer combines neurons with silicon

Australian start-up Cortical Labs unveiled CL1, a hybrid chip designed to help scientists study brain function in real-time. The 800,000 lab-grown neurons on the chip are kept viable for six months via a built-in life support system.

Harvard and MIT researchers are developing life-saving tattoos

Tattoos aren’t just a fashion statement. Scientists are trying to find life-saving applications for them. Harvard and MIT researchers are developing tattoo inks that react to body chemicals, alerting diabetics to blood sugar fluctuations or athletes to dehydration. Someday, patients may observe their body chemistry with tattoos that change colors.

The legacy of America's most remarkable kid

The short life and legacy of Kevin Cooper, a 14-year-old entrepreneur from Utah with big dreams for his family and rural America, and whose accomplishments most adults don’t pull off in a lifetime.

One dad, one hundred babies

A look at the companies offering surrogacy to the ultrarich—including Chinese men taking their reproductive cues from Elon Musk.

How to make a billion dollars, with Brad Jacobs

Brad Jacobs is a serial entrepreneur who has launched eight billion-dollar enterprises during his storied financial career. With companies focused in energy, waste, and more, Jacobs has stuck to a roll-up playbook of consolidating small players into one conglomerate within an industry, a common tactic of similar private equity firms. This podcast from Founders summarizes Jacobs' book detailing his approach.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The $3B project scientists called 'junk'

In 1990, scientists set out to map all of human DNA. A $3B bet many called "junk." But the Human Genome Project's radical transparency and a race with a private company sped it to completion in just 13 years. Today, that once-contested map underpins nearly every breakthrough in genetics and personalized medicine.

The story of a bitcoin loophole that gave one man millions

James Parker discovered a glitch in an Australian cryptocurrency exchange that would allow him to cash in credits worth over $20M and make big gifts to his friends. Like most loopholes, the authorities found out, but not before his life was transformed. The first in a six-part series.

Steve Bannon was made CEO of the company in charge of Biosphere 2 in 1994

After providing $200M to launch and upgrade B2 before its second mission, billionaire philanthropist Ed Bass appointed the future political strategist and then financial consultant to help find new investments and bring costs under control. Fearing interference from non-science experts, Biospherians from the first mission vandalized the project.

Mark Zuckerberg's 2024 rebrand was dubbed the 'Zuckassaince'

Zuckerberg, like Apple cofounder Steve Jobs, wore the same, simple T-shirts and outfits for most of his early career to decrease the decisions he'd have to make on a daily basis. In 2024, Zuckerberg started wearing chunky gold chains around his neck and oversized T-shirts with slogans on them. Some say the "Zuckassaince" is an effort to rebrand Meta as a futuristic company, not just an old social media company for millennials.

A 13-year-old was declared brain-dead yet went through puberty on a ventilator

This podcast details Jahi McMath's highly controversial case. She was declared brain-dead in 2013 following surgical complications, but her family, citing religious beliefs, kept her connected to a ventilator for the five years that followed. She continued to grow and went through puberty before being issued a second death certificate in New Jersey.

Long-term evolution experiments use microbe's short generations to speed up selection

With quick generations of microbes, scientists can speed up the evolutionary process, with projects like the LTEE in California running for 40 years and generating 80,000 generations of E. coli.

One jellyfish species is biologically immortal

Turritopsis dohrnii is a type of jellyfish that can revert back to a juvenile stage after reaching sexual maturity, theoretically allowing it to stay alive for good. But that's a tough sell in a world full of predators. See this list of some of the longest-living species on Earth.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Track the location of the Voyager probes, currently between 13 and 15 billion miles away from Earth.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.