Inside entrepreneur Bryan Johnson's race to live forever

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Developing adaptable brain-body systems lets athletes thrive beyond 30

Success in high-level sports after age 30 relies on physical fitness and building brain resilience through deliberate training, recovery, and stress regulation. This creates a feedback loop where body and mind reinforce each other.

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

'Endoevolution' refers to the Darwinian selection happening continually inside us

The term, coined by Roxanne Khamsi in her 2026 book "Beyond Inheritance: Our Ever-Mutating Cells and a New Understanding of Health" describes the idea that evolution does not just occur across generations of humans. Instead, mutated cells continuously compete with healthy ones in our bodies, with implications for our tissues and health. Khamsi says these autocorrections are essentially natural gene therapy. 

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

The legacy of America's most remarkable kid

The short life and legacy of Kevin Cooper, a 14-year-old entrepreneur from Utah with big dreams for his family and rural America, and whose accomplishments most adults don’t pull off in a lifetime.

Ten writers and thinkers on what growing older actually requires of us

The Marginalian's Maria Popova curates a collection arguing our culture has learned to dread aging while forgetting it is a privilege, and that the antidote is sustaining passions strong enough to keep us from turning inward. Voices include Simone de Beauvoir, Joan Didion, Pablo Casals, and Kahlil Gibran.

An avowed rationalist discusses his near-death experience

Documentarian Sebastian Junger, a veteran reporter and skeptic discusses his experiences—in particular, a frightening vision—after an aneurysm and internal hemorrhaging left him nearly dead. Junger talks about his NDE, the possible scientific explanations, and how that day changed his fundamental worldview.

See what it's like to live 'Constitutionally' for a year

In a 2023 interview on CBS Sunday Morning, author A.J. Jacobs discusses his attempt to live as closely as possible by the principles of the US Constitution for a whole year and the book that resulted from the experiment.

'The man who can drive himself further once the effort gets painful is the man who will win.'

- Roger Bannister (1929-2018)

The economics of horseshoe crab blood

Horseshoe crabs are older than dinosaurs and have survived five mass extinctions that wiped most life from the planet. But it's only now that their future as a species is in danger. This blood, worth about $60,000 per gallon, is hyper-sensitized to certain bacteria that are fatal to humans. This 17-minute podcast dives into humanity's pursuit of horseshoe crab blood, a "somewhat magical" mixture heavily relied on by the pharmaceutical industry.

Modern bodybuilding evolved in the 19th century

The origins of modern progressive resistance exercise are traced to ancient Greece, where a repeat Olympic victor carried a calf every day until it grew into a full-sized ox. This 56-minute comedy and history podcast journeys through the rise of modern bodybuilding, which took off during the 19th century.

Dangers of a record-breaking, sleep-skipping stunt

In 1963, 17-year-old Randy Gardner decided to stay awake for as long as it took to break the current world record. He managed to stay awake for 11 days. In 2017, the then-71-year-old Gardner told NPR that his experience had come back to haunt him as insomnia. The challenge has since been removed from the Guinness Book of World Records due to its dangerous consequences.

History’s largest intergenerational wealth transfer is happening in the next few decades

The founder of a multifamily office firm offers lessons on how to preserve wealth for generations from a global perspective, like educating younger family members.

The X Games hired new CEO Jeremy Bloom in December 2024

In this podcast interview, X Games CEO Jeremy Bloom reflects on his first time running the competition—discussing event logistics, athlete relations, and strategies to grow the brand under new ownership.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Two festival-goers were hospitalized after receiving peptide injections, raising questions

Investigative journalism shop ProPublica wrote about two people who became extremely ill following antiaging peptide injections. Authorities were examining whether the individuals were sickened by an infection, contamination related to the injections, or an issue with the medication itself, according to documents obtained by the journalists at ProPublica.

Menopause may become a $600B industry

Companies marketing products and supplements to alleviate menopause symptoms and make life easier during this life stage have become a gold mine. This 2022 article explores how and why companies have swooped into this space, and whether you should trust them or not.

Virtually experience a euthanasia roller coaster

In 2010, Lithuanian artist Julijonas Urbonas came up with a fictional euthanasia coaster to generate conversation about humanely ending life. His idea involved using extreme G-forces on a roller coaster, aiming to give participants feelings of euphoria before death. In reality, the ride would probably be extremely unpleasant.

Gen Z is increasingly interested in running marathons

The race has become a popular event for young people. Over 12,000 20-somethings signed up for the New York Marathon in 2024. That's a significant increase from 2023 (9.987) and 2022 (8,039).

Billionaires are racing to space to control future markets

Although different companies have described focuses ranging from luxury tourism to Martian space colonies, all are building infrastructure to capitalize on the shift away from government-only control and betting big on reusability and scale. By securing public contracts and subsidies, they aim to develop strategic partnerships toward dominance in low Earth orbit.

Friedrich Nietzsche theorized that we will live our lives over and over again: the myth of eternal recurrence

Rather than a theory of physics, the idea is designed as a moral argument. While Nietzsche famously eschewed the Christian afterlife, he wanted to avoid the nihilism that results from no longer having such an ultimate horizon. In a mystical moment, the philosopher came to believe that the fleeting moments of our lives would be repeated, presenting a test: would you want to relive this moment? If not, he would argue, you're not living well.

Olympians view sleep as a performance tool, prioritizing routine and environment

Elite athletes emphasize consistent sleep routines, dark and cool environments, the well-placed nap, and tools like eye masks, white noise machines, and supplements like melatonin (particularly for jet lag). This priority belies a core principle: recovery and performance are inseparable. Read more ways Olympians "sleepmaxx" here.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

How YouTube's biggest creator changed the platform forever

Jimmy Donaldson, aka MrBeast, has accrued 241 million subscribers on YouTube by obsessing over content and spending sometimes millions to produce a single video. He is known for recording himself doing extreme stunts, like staying underwater for 24 hours, and gifting people with large amounts of money. Creators have imitated his style ever since. Dive into how MrBeast transformed YouTube here.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.