Anopheles mosquitoes are developing resistance to insecticides

Researchers are breeding genetically modified mosquitoes to be malaria-resistant

Using CRISPR, a team of international researchers is genetically modifying Anopheles in the lab to be malaria-resistant. The insects would be released into the wild to mate with the wild population, passing down this trait. As of early 2026 they had not yet released the mosquitoes into the wild for field trials. Separate CRISPR work seeks to reduce the Anopheles population altogether.

See this graphic of the complex malaria transmission lifecycle

Female Anopheles mosquitoes contract malaria by feeding on the blood of a human already infected with the disease-causing parasite. The parasite then develops in the mosquito's gut for one to two weeks before it migrates to the mosquito's salivary glands. Next, when the mosquito bites another person the parasite is delivered into the bloodstream of another human. This graphic further details what happens inside the human body during infection.

Female Anopheles mosquito bites are the primary way malaria spreads

Females are the only ones that bite: They need blood to get essential nutrients for egg development. Very rarely, the disease is also spread via blood transfusions, organ transplants, shared needles, or from mother to fetus during pregnancy or birth.

How we helped make Aedes aegypti mosquitoes such a problem

Mosquito genome sequencing data suggests that Aedes aegypti mosquitoes first started specializing on human blood around 5,000 years ago—when climates shifted and humans started domesticating plants in Africa and stored large amounts of water that may have attracted the bugs.

Pregnancy makes someone more attractive to the mosquito species that transmits malaria

Research suggests that hormonal levels can affect mosquito attraction. Pregnancy, in particular, is associated with significantly increased interest from Anopheles mosquitoes, which boosts pregnant women's malaria risk.

Antimalarials must be taken before traveling to a malaria-endemic area

Malaria prevention involves avoiding getting bitten by mosquitoes (with bug spray and clothing choices) and taking malaria preventative drugs before, during, and after spending time in an area with malaria risk. The drug must be in the blood before the traveler is exposed to malaria parasites.

Mosquitoes top the ranking of the world's deadliest animals

Mosquitos kill about 760,000 people every year. The vast majority of those deaths are caused by malaria, which is transmitted and spread by the Anopheles mosquito. The second-place deadliest animal title goes to snakes, with an estimated human death toll of around 100,000 annually.

The most severe form of malaria is caused by the Plasmodium falciparum parasite

Multiple species of a single-celled organism called a protozoa cause malaria infection when transmitted by a mosquito bite. But Plasmodium falciparum is the most widespread in Africa, and the most deadly.

Wolbachia is a naturally occurring bacterium being employed to fight dengue

Scientists are fighting dengue spread in a roundabout way: injecting bacteria into Aedes aegypti mosquito eggs, which blocks the dengue virus from replicating in the tissue of mosquitoes. Researchers hope the bacterium will be passed to future generations, inoculating them against dengue. Wolbachia is also being investigated to combat other mosquito-borne diseases.

How bedbugs have evolved immunity against pesticides

Bedbugs, once nearly eradicated in the United States due to the use of pesticides like DDT, have made a resurgence, with New York being declared the most bedbug-infested city. The primary reason for the return is the evolution of resistance in...

10 locally acquired malaria cases were reported in the US in 2023—a surprise

The cases, reported in Florida, Texas, Maryland, and Arkansas, broke a 20-year streak since there had been no reported locally acquired mosquito-transmitted malaria in the country since 2003, when there was a case in Florida.

Hear what it's like to have malaria

In Kenya, as one malaria-sufferer explains, the disease is common enough that anytime a child has a fever or any sort of sickness families and the community will wonder if it's malaria. Sleeping under a mosquito net is recommended. Unfortunately, a gin and tonic will not keep malaria at bay.

The mosquito's role in the transmission of malaria was confirmed in 1897

The British army doctor Ronald Ross, who later won the Nobel Prize for his work, was the first to describe the transmission of malarial parasites by mosquitoes. He had lab mosquitoes suck blood from malaria-infected people and separately found the malaria parasite inside a mosquito's gut, confirming the bug's role in malaria transmission.

Mosquitoes even have olfactory receptors on their sperm

Male mosquitoes, which don't bite humans, have fewer olfactory receptors than females on their antennae—they don't need them to locate blood meals. But they do have this same type of receptor located in the tail of their sperm, thought to help bring egg and sperm together.

Malaria comes from the Italian term 'mal'aria,' meaning 'bad air'

The term refers to marshy areas associated with the disease. An estimated 94% of malaria cases—215 million—occur in Africa.

Yes, many animals get malaria—not just humans

Birds, rodents, monkeys, lizards, bats, apes, and livestock are among the species that can become infected with malaria. Infected animals' symptoms often resemble those of humans, including fever, lethargy, loss of appetite and difficulty breathing. Birds will also have ruffled feathers and drooped heads.

Iceland, the last mosquito-free country, detected them in 2025

Recently several of the mosquito species Culiseta annulata were documented in Iceland—the last country that had not yet seen them, underscoring that climate change is shifting the bugs' patterns. Mosquitoes can hide out in human structures to survive icy temperatures. The bugs are now known to live everywhere except the continent of Antarctica.

There are two recommended malaria vaccines

Two vaccines are currently recommended by world health experts for children living in areas where malaria transmission is common. The first, RTS,S/ASO1, formally became recommended for use by the World Health Organization in October 2021, and the second was approved by the WHO two years later. Both have faced logistical, financial, and uptake challenges.

Untreated malaria can lead to blocked blood vessels in the brain, coma, and organ failure

Malaria is treatable with medications, but sometimes even after treatment, infection can come back because the disease-causing parasite wasn't completely eliminated. Patients may also have symptoms that emerge years after the initial infection and treatment.

How Disney World keeps out mosquitos

Disney World may have been built on a swamp, but it's nearly free from the annoyance of mosquitos. That hasn't been an easy task; Disney has worked with engineers and pest specialists on minimizing the invasive bugs through a variety of different methods. This Reader's Digest article breaks down how they've successfully kept the park free from these unwanted guests.

Drug-resistant infections worldwide have increased by about 65% since 2000

Since 1990, antibiotic resistance has claimed at least one million lives annually and is projected to account for 39 million deaths between now and 2050 if current trends continue. The expanded use of antibiotics, particularly in agriculture, combined with a slowing pipeline of new drugs has led to the crisis.

Poison frogs get their toxins from eating insects and mice

Other animals, including royal ground snakes, are able to survive eating poison. Scientists study the creative antitoxin defenses in these animals to discover treatments for poisoning.

South Asia and sub-Saharan Africa are most at risk from falling pollinator numbers

Researchers at the Harvard T.H. Chan School of Public Health found that declines in pollinator populations would lead to higher rates of nutritional deficiencies, particularly in developing nations. Nations with large populations, such as China and India, would also be significantly impacted.

Parasites have circadian rhythms, too

Researchers are working to unravel how circadian rhythms of parasites and their hosts affect one another. They’re investigating how to potentially target and disrupt those clocks for disease treatments.

Scientists have struggled to pin down Ebola's natural reservoir species for decades, but the available evidence suggests that it's very likely fruit and insect-eating bats found in Africa.

Two invasive termite species are threatening Florida homes

Asian subterranean and Formosan subterranean termites have been found in northern and coastal counties, respectively. About half of all structures in the urban South Florida metropolitan area could be at risk of infestation by one or both species by 2040.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Poison ivy will likely become both larger and more resilient due to climate change.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Tattoos remain visible on your skin thanks to immune cells called macrophages

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Hurricanes, which rely on air consistently spinning in the same direction, cannot cross the equator because air curves in opposite directions north and south of it.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

Hotels in Cannes, the glamorous city on the French Riviera, hire hawks to ward off seagulls during the city's famous film festival.